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Journal Abstract Search


607 related items for PubMed ID: 16033885

  • 1. Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.
    Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.
    J Neurosci; 2005 Jul 20; 25(29):6755-64. PubMed ID: 16033885
    [Abstract] [Full Text] [Related]

  • 2. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
    Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F.
    J Neurosci; 2002 May 01; 22(9):3445-53. PubMed ID: 11978821
    [Abstract] [Full Text] [Related]

  • 3. APP processing and synaptic plasticity in presenilin-1 conditional knockout mice.
    Yu H, Saura CA, Choi SY, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J.
    Neuron; 2001 Sep 13; 31(5):713-26. PubMed ID: 11567612
    [Abstract] [Full Text] [Related]

  • 4. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.
    Sadowski M, Pankiewicz J, Scholtzova H, Ji Y, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, Wisniewski T.
    J Neuropathol Exp Neurol; 2004 May 13; 63(5):418-28. PubMed ID: 15198121
    [Abstract] [Full Text] [Related]

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  • 6. Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer's disease by regulating hippocampal mitochondrial dynamics.
    Jia WW, Lin HW, Yang MG, Dai YL, Ding YY, Xu WS, Wang SN, Cao YJ, Liang SX, Wang ZF, Chen C, Liu WL.
    J Integr Med; 2024 Sep 13; 22(5):588-599. PubMed ID: 39181774
    [Abstract] [Full Text] [Related]

  • 7. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H, Capell A, Leimer U, Haass C.
    Eur Arch Psychiatry Clin Neurosci; 1999 Sep 13; 249(6):266-70. PubMed ID: 10653281
    [Abstract] [Full Text] [Related]

  • 8. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
    Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF.
    Eur J Neurosci; 2006 Jan 13; 23(1):251-60. PubMed ID: 16420434
    [Abstract] [Full Text] [Related]

  • 9. Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.
    Kimura R, Devi L, Ohno M.
    J Neurochem; 2010 Apr 13; 113(1):248-61. PubMed ID: 20089133
    [Abstract] [Full Text] [Related]

  • 10. Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.
    Arendash GW, King DL, Gordon MN, Morgan D, Hatcher JM, Hope CE, Diamond DM.
    Brain Res; 2001 Feb 09; 891(1-2):42-53. PubMed ID: 11164808
    [Abstract] [Full Text] [Related]

  • 11. Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.
    Devi L, Ohno M.
    Eur J Neurosci; 2010 Jan 09; 31(1):110-8. PubMed ID: 20092558
    [Abstract] [Full Text] [Related]

  • 12. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W.
    Exp Gerontol; 2000 Jul 09; 35(4):453-60. PubMed ID: 10959033
    [Abstract] [Full Text] [Related]

  • 13. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
    Ye X, Feng T, Tammineni P, Chang Q, Jeong YY, Margolis DJ, Cai H, Kusnecov A, Cai Q.
    J Neurosci; 2017 Mar 08; 37(10):2639-2655. PubMed ID: 28159908
    [Abstract] [Full Text] [Related]

  • 14. Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Aβ pathology and improves cognitive function.
    Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL.
    Exp Mol Med; 2012 Dec 31; 44(12):740-8. PubMed ID: 23172351
    [Abstract] [Full Text] [Related]

  • 15. Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice.
    Zhao G, Liu HL, Zhang H, Tong XJ.
    Neuroscience; 2015 Jul 09; 298():357-66. PubMed ID: 25917310
    [Abstract] [Full Text] [Related]

  • 16. Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
    Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.
    J Biol Chem; 2010 Sep 03; 285(36):27737-44. PubMed ID: 20595388
    [Abstract] [Full Text] [Related]

  • 17. Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
    Cai Z, Wang C, He W, Chen Y.
    Curr Alzheimer Res; 2018 Sep 03; 15(11):1045-1052. PubMed ID: 29962345
    [Abstract] [Full Text] [Related]

  • 18. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
    Pitsi D, Kienlen-Campard P, Octave JN.
    J Neurochem; 2002 Oct 03; 83(2):390-9. PubMed ID: 12423249
    [Abstract] [Full Text] [Related]

  • 19. Age-related changes in hippocampal AD pathology, actin remodeling proteins and spatial memory behavior of male APP/PS1 mice.
    Sun H, Liu M, Sun T, Chen Y, Lan Z, Lian B, Zhao C, Liu Z, Zhang J, Liu Y.
    Behav Brain Res; 2019 Dec 30; 376():112182. PubMed ID: 31472195
    [Abstract] [Full Text] [Related]

  • 20. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.
    Johnson ECB, Ho K, Yu GQ, Das M, Sanchez PE, Djukic B, Lopez I, Yu X, Gill M, Zhang W, Paz JT, Palop JJ, Mucke L.
    Mol Neurodegener; 2020 Sep 14; 15(1):53. PubMed ID: 32921309
    [Abstract] [Full Text] [Related]


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