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Journal Abstract Search

234 related items for PubMed ID: 16050272

  • 1. TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability).
    Hondeghem LM.
    Novartis Found Symp; 2005; 266():235-44; discussion 244-50. PubMed ID: 16050272
    [Abstract] [Full Text] [Related]

  • 2. Thorough QT/QTc not so thorough: removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs.
    Hondeghem LM.
    J Cardiovasc Electrophysiol; 2006 Mar; 17(3):337-40. PubMed ID: 16643415
    [Abstract] [Full Text] [Related]

  • 3. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic.
    Hondeghem LM, Carlsson L, Duker G.
    Circulation; 2001 Apr 17; 103(15):2004-13. PubMed ID: 11306531
    [Abstract] [Full Text] [Related]

  • 4. Drug-induced QT-interval prolongation and proarrhythmic risk in the treatment of atrial arrhythmias.
    Shantsila E, Watson T, Lip GY.
    Europace; 2007 Sep 17; 9 Suppl 4():iv37-44. PubMed ID: 17766322
    [Abstract] [Full Text] [Related]

  • 5. Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes.
    Milberg P, Eckardt L, Bruns HJ, Biertz J, Ramtin S, Reinsch N, Fleischer D, Kirchhof P, Fabritz L, Breithardt G, Haverkamp W.
    J Pharmacol Exp Ther; 2002 Oct 17; 303(1):218-25. PubMed ID: 12235254
    [Abstract] [Full Text] [Related]

  • 6. QT and TdP. QT: an unreliable predictor of proarrhythmia.
    Hondeghem LM.
    Acta Cardiol; 2008 Feb 17; 63(1):1-7. PubMed ID: 18372573
    [Abstract] [Full Text] [Related]

  • 7. Refining detection of drug-induced proarrhythmia: QT interval and TRIaD.
    Shah RR, Hondeghem LM.
    Heart Rhythm; 2005 Jul 17; 2(7):758-72. PubMed ID: 15992736
    [Abstract] [Full Text] [Related]

  • 8. Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes.
    Milberg P, Hilker E, Ramtin S, Cakir Y, Stypmann J, Engelen MA, Mönnig G, Osada N, Breithardt G, Haverkamp W, Eckardt L.
    J Cardiovasc Electrophysiol; 2007 Jun 17; 18(6):647-54. PubMed ID: 17388913
    [Abstract] [Full Text] [Related]

  • 9. Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil.
    Aiba T, Shimizu W, Inagaki M, Noda T, Miyoshi S, Ding WG, Zankov DP, Toyoda F, Matsuura H, Horie M, Sunagawa K.
    J Am Coll Cardiol; 2005 Jan 18; 45(2):300-7. PubMed ID: 15653031
    [Abstract] [Full Text] [Related]

  • 10. Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
    Said TH, Wilson LD, Jeyaraj D, Fossa AA, Rosenbaum DS.
    J Cardiovasc Pharmacol; 2012 Aug 18; 60(2):165-71. PubMed ID: 22561361
    [Abstract] [Full Text] [Related]

  • 11. In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.
    Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ.
    Eur J Pharmacol; 2006 Dec 28; 553(1-3):229-39. PubMed ID: 17054943
    [Abstract] [Full Text] [Related]

  • 12. QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development.
    Recanatini M, Poluzzi E, Masetti M, Cavalli A, De Ponti F.
    Med Res Rev; 2005 Mar 28; 25(2):133-66. PubMed ID: 15389727
    [Abstract] [Full Text] [Related]

  • 13. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
    Lu HR, Yan GX, Gallacher DJ.
    J Pharmacol Toxicol Methods; 2013 Mar 28; 68(2):250-259. PubMed ID: 23337247
    [Abstract] [Full Text] [Related]

  • 14. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
    Jacobson I, Carlsson L, Duker G.
    J Pharmacol Toxicol Methods; 2011 Mar 28; 63(1):40-6. PubMed ID: 20451633
    [Abstract] [Full Text] [Related]

  • 15. Pentamidine-induced long QT syndrome and block of hERG trafficking.
    Kuryshev YA, Ficker E, Wang L, Hawryluk P, Dennis AT, Wible BA, Brown AM, Kang J, Chen XL, Sawamura K, Reynolds W, Rampe D.
    J Pharmacol Exp Ther; 2005 Jan 28; 312(1):316-23. PubMed ID: 15340016
    [Abstract] [Full Text] [Related]

  • 16. Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing.
    Fish JM, Di Diego JM, Nesterenko V, Antzelevitch C.
    Circulation; 2004 May 04; 109(17):2136-42. PubMed ID: 15078801
    [Abstract] [Full Text] [Related]

  • 17. Drug-induced QT prolongation and proarrhythmia: an inevitable link?
    Ahmad K, Dorian P.
    Europace; 2007 Sep 04; 9 Suppl 4():iv16-22. PubMed ID: 17766320
    [Abstract] [Full Text] [Related]

  • 18. Nonclinical proarrhythmia models: predicting Torsades de Pointes.
    Lawrence CL, Pollard CE, Hammond TG, Valentin JP.
    J Pharmacol Toxicol Methods; 2005 Sep 04; 52(1):46-59. PubMed ID: 15975832
    [Abstract] [Full Text] [Related]

  • 19. Disturbances of cardiac wavelength and repolarization precede Torsade de Pointes and ventricular fibrillation in Langendorff perfused rabbit hearts.
    Hondeghem LM.
    Prog Biophys Mol Biol; 2016 May 04; 121(1):3-10. PubMed ID: 26980523
    [Abstract] [Full Text] [Related]

  • 20. Inhibitory effect of erythromycin on potassium currents in rat ventricular myocytes in comparison with disopyramide.
    Hanada E, Ohtani H, Hirota M, Uemura N, Nakaya H, Kotaki H, Sato H, Yamada Y, Iga T.
    J Pharm Pharmacol; 2003 Jul 04; 55(7):995-1002. PubMed ID: 12906757
    [Abstract] [Full Text] [Related]

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