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366 related items for PubMed ID: 16054061

  • 1. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol.
    Song BL, Javitt NB, DeBose-Boyd RA.
    Cell Metab; 2005 Mar; 1(3):179-89. PubMed ID: 16054061
    [Abstract] [Full Text] [Related]

  • 2. Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase.
    Johnson BM, DeBose-Boyd RA.
    Semin Cell Dev Biol; 2018 Sep; 81():121-128. PubMed ID: 29107682
    [Abstract] [Full Text] [Related]

  • 3. Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2.
    Lee PC, Sever N, Debose-Boyd RA.
    J Biol Chem; 2005 Jul 01; 280(26):25242-9. PubMed ID: 15866869
    [Abstract] [Full Text] [Related]

  • 4. Insulin-induced gene: a new regulator in lipid metabolism.
    Dong XY, Tang SQ.
    Peptides; 2010 Nov 01; 31(11):2145-50. PubMed ID: 20817058
    [Abstract] [Full Text] [Related]

  • 5. Intramembrane glycine mediates multimerization of Insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.
    Lee PC, DeBose-Boyd RA.
    J Lipid Res; 2010 Jan 01; 51(1):192-201. PubMed ID: 19617589
    [Abstract] [Full Text] [Related]

  • 6. Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.
    DeBose-Boyd RA.
    Cell Res; 2008 Jun 01; 18(6):609-21. PubMed ID: 18504457
    [Abstract] [Full Text] [Related]

  • 7. Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.
    Nguyen AD, McDonald JG, Bruick RK, DeBose-Boyd RA.
    J Biol Chem; 2007 Sep 14; 282(37):27436-27446. PubMed ID: 17635920
    [Abstract] [Full Text] [Related]

  • 8. Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.
    Rodrigue-Way A, Caron V, Bilodeau S, Keil S, Hassan M, Lévy E, Mitchell GA, Tremblay A.
    FASEB J; 2014 Apr 14; 28(4):1910-23. PubMed ID: 24371122
    [Abstract] [Full Text] [Related]

  • 9. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.
    Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA.
    Mol Cell; 2003 Jan 14; 11(1):25-33. PubMed ID: 12535518
    [Abstract] [Full Text] [Related]

  • 10. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
    Song BL, Sever N, DeBose-Boyd RA.
    Mol Cell; 2005 Sep 16; 19(6):829-40. PubMed ID: 16168377
    [Abstract] [Full Text] [Related]

  • 11. Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols.
    Song BL, DeBose-Boyd RA.
    J Biol Chem; 2006 Sep 01; 281(35):25054-61. PubMed ID: 16831864
    [Abstract] [Full Text] [Related]

  • 12. Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    Sever N, Lee PC, Song BL, Rawson RB, Debose-Boyd RA.
    J Biol Chem; 2004 Oct 08; 279(41):43136-47. PubMed ID: 15247248
    [Abstract] [Full Text] [Related]

  • 13. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
    Gong Y, Lee JN, Lee PC, Goldstein JL, Brown MS, Ye J.
    Cell Metab; 2006 Jan 08; 3(1):15-24. PubMed ID: 16399501
    [Abstract] [Full Text] [Related]

  • 14. Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase.
    Faulkner RA, Yang Y, Tsien J, Qin T, DeBose-Boyd RA.
    Proc Natl Acad Sci U S A; 2024 Feb 13; 121(7):e2318822121. PubMed ID: 38319967
    [Abstract] [Full Text] [Related]

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  • 17. Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.
    Jiang LY, Jiang W, Tian N, Xiong YN, Liu J, Wei J, Wu KY, Luo J, Shi XJ, Song BL.
    J Biol Chem; 2018 Mar 16; 293(11):4047-4055. PubMed ID: 29374057
    [Abstract] [Full Text] [Related]

  • 18. Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase.
    Song BL, DeBose-Boyd RA.
    J Biol Chem; 2004 Jul 02; 279(27):28798-806. PubMed ID: 15090540
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