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265 related items for PubMed ID: 16107153

  • 1. Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
    El-Kabbani O, Carbone V, Darmanin C, Oka M, Mitschler A, Podjarny A, Schulze-Briese C, Chung RP.
    J Med Chem; 2005 Aug 25; 48(17):5536-42. PubMed ID: 16107153
    [Abstract] [Full Text] [Related]

  • 2. Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.
    Petrova T, Steuber H, Hazemann I, Cousido-Siah A, Mitschler A, Chung R, Oka M, Klebe G, El-Kabbani O, Joachimiak A, Podjarny A.
    J Med Chem; 2005 Sep 08; 48(18):5659-65. PubMed ID: 16134934
    [Abstract] [Full Text] [Related]

  • 3. Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors.
    El-Kabbani O, Darmanin C, Schneider TR, Hazemann I, Ruiz F, Oka M, Joachimiak A, Schulze-Briese C, Tomizaki T, Mitschler A, Podjarny A.
    Proteins; 2004 Jun 01; 55(4):805-13. PubMed ID: 15146479
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  • 5. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
    Ruiz FX, Cousido-Siah A, Mitschler A, Farrés J, Parés X, Podjarny A.
    Chem Biol Interact; 2013 Feb 25; 202(1-3):178-85. PubMed ID: 23295227
    [Abstract] [Full Text] [Related]

  • 6. Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor.
    Carbone V, Giglio M, Chung R, Huyton T, Adams J, Maccari R, Ottana R, Hara A, El-Kabbani O.
    Eur J Med Chem; 2010 Mar 25; 45(3):1140-5. PubMed ID: 20036445
    [Abstract] [Full Text] [Related]

  • 7. High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.
    El-Kabbani O, Darmanin C, Oka M, Schulze-Briese C, Tomizaki T, Hazemann I, Mitschler A, Podjarny A.
    J Med Chem; 2004 Aug 26; 47(18):4530-7. PubMed ID: 15317464
    [Abstract] [Full Text] [Related]

  • 8. Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: implications for the inhibition mechanism.
    Zhao HT, Hazemann I, Mitschler A, Carbone V, Joachimiak A, Ginell S, Podjarny A, El-Kabbani O.
    J Med Chem; 2008 Mar 13; 51(5):1478-81. PubMed ID: 18284183
    [Abstract] [Full Text] [Related]

  • 9. Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme.
    El-Kabbani O, Ramsland P, Darmanin C, Chung RP, Podjarny A.
    Proteins; 2003 Feb 01; 50(2):230-8. PubMed ID: 12486717
    [Abstract] [Full Text] [Related]

  • 10. Charge density and electrostatic interactions of fidarestat, an inhibitor of human aldose reductase.
    Fournier B, Bendeif el-E, Guillot B, Podjarny A, Lecomte C, Jelsch C.
    J Am Chem Soc; 2009 Aug 12; 131(31):10929-41. PubMed ID: 19594152
    [Abstract] [Full Text] [Related]

  • 11. A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
    Oka M, Matsumoto Y, Sugiyama S, Tsuruta N, Matsushima M.
    J Med Chem; 2000 Jun 15; 43(12):2479-83. PubMed ID: 10882376
    [Abstract] [Full Text] [Related]

  • 12. Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations.
    Sotriffer CA, Krämer O, Klebe G.
    Proteins; 2004 Jul 01; 56(1):52-66. PubMed ID: 15162486
    [Abstract] [Full Text] [Related]

  • 13. Structural features of the aldose reductase and aldehyde reductase inhibitor-binding sites.
    El-Kabbani O, Wilson DK, Petrash M, Quiocho FA.
    Mol Vis; 1998 Sep 29; 4():19. PubMed ID: 9756955
    [Abstract] [Full Text] [Related]

  • 14. 3D-pharmacophore analyses of aldose reductase inhibitory spiroquinazolinones.
    Nakao K, Asao M, Shirai H, Shimizu R.
    Drug Des Discov; 1999 Aug 29; 16(2):155-63. PubMed ID: 10533811
    [Abstract] [Full Text] [Related]

  • 15. Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.
    Steuber H, Heine A, Klebe G.
    J Mol Biol; 2007 May 04; 368(3):618-38. PubMed ID: 17368668
    [Abstract] [Full Text] [Related]

  • 16. The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.
    Ruiz F, Hazemann I, Mitschler A, Joachimiak A, Schneider T, Karplus M, Podjarny A.
    Acta Crystallogr D Biol Crystallogr; 2004 Aug 04; 60(Pt 8):1347-54. PubMed ID: 15272156
    [Abstract] [Full Text] [Related]

  • 17. High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group.
    Steuber H, Zentgraf M, Podjarny A, Heine A, Klebe G.
    J Mol Biol; 2006 Feb 10; 356(1):45-56. PubMed ID: 16337231
    [Abstract] [Full Text] [Related]

  • 18. Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis.
    Sundaram K, Dhagat U, Endo S, Chung R, Matsunaga T, Hara A, El-Kabbani O.
    Bioorg Med Chem Lett; 2011 Jan 15; 21(2):801-4. PubMed ID: 21168333
    [Abstract] [Full Text] [Related]

  • 19. The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
    Harrison DH, Bohren KM, Petsko GA, Ringe D, Gabbay KH.
    Biochemistry; 1997 Dec 23; 36(51):16134-40. PubMed ID: 9405046
    [Abstract] [Full Text] [Related]

  • 20. Studies on the inhibitor-binding site of porcine aldehyde reductase: crystal structure of the holoenzyme-inhibitor ternary complex.
    el-Kabbani O, Carper DA, McGowan MH, Devedjiev Y, Rees-Milton KJ, Flynn TG.
    Proteins; 1997 Oct 23; 29(2):186-92. PubMed ID: 9329083
    [Abstract] [Full Text] [Related]

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