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224 related items for PubMed ID: 16162831

  • 1. Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats.
    McGaraughty S, Chu KL, Faltynek CR, Jarvis MF.
    J Neurophysiol; 2006 Jan; 95(1):18-25. PubMed ID: 16162831
    [Abstract] [Full Text] [Related]

  • 2. Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.
    McGaraughty S, Chu KL, Brown BS, Zhu CZ, Zhong C, Joshi SK, Honore P, Faltynek CR, Jarvis MF.
    J Neurophysiol; 2008 Dec; 100(6):3158-66. PubMed ID: 18829846
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of peripheral vanilloid TRPV1 receptors reduces noxious heat-evoked responses of dorsal horn neurons in naïve, carrageenan-inflamed and neuropathic rats.
    Jhaveri MD, Elmes SJ, Kendall DA, Chapman V.
    Eur J Neurosci; 2005 Jul; 22(2):361-70. PubMed ID: 16045489
    [Abstract] [Full Text] [Related]

  • 4. Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia.
    Kanai Y, Hara T, Imai A, Sakakibara A.
    J Pharm Pharmacol; 2007 May; 59(5):733-8. PubMed ID: 17524240
    [Abstract] [Full Text] [Related]

  • 5. RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat.
    Kasama S, Kawakubo M, Suzuki T, Nishizawa T, Ishida A, Nakayama J.
    Eur J Neurosci; 2007 May; 25(10):2956-63. PubMed ID: 17509082
    [Abstract] [Full Text] [Related]

  • 6. (R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo.
    Surowy CS, Neelands TR, Bianchi BR, McGaraughty S, El Kouhen R, Han P, Chu KL, McDonald HA, Vos M, Niforatos W, Bayburt EK, Gomtsyan A, Lee CH, Honore P, Sullivan JP, Jarvis MF, Faltynek CR.
    J Pharmacol Exp Ther; 2008 Sep; 326(3):879-88. PubMed ID: 18515644
    [Abstract] [Full Text] [Related]

  • 7. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats.
    McGaraughty S, Chu KL, Perner RJ, Didomenico S, Kort ME, Kym PR.
    Mol Pain; 2010 Mar 05; 6():14. PubMed ID: 20205719
    [Abstract] [Full Text] [Related]

  • 8. A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.
    McGaraughty S, Chu KL, Scanio MJ, Kort ME, Faltynek CR, Jarvis MF.
    J Pharmacol Exp Ther; 2008 Mar 05; 324(3):1204-11. PubMed ID: 18089840
    [Abstract] [Full Text] [Related]

  • 9. Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats.
    Xu J, Chu KL, Brederson JD, Jarvis MF, McGaraughty S.
    J Neurosci Res; 2012 Aug 05; 90(8):1597-606. PubMed ID: 22422599
    [Abstract] [Full Text] [Related]

  • 10. Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist.
    Amaya F, Shimosato G, Kawasaki Y, Hashimoto S, Tanaka Y, Ji RR, Tanaka M.
    Pain; 2006 Sep 05; 124(1-2):175-83. PubMed ID: 16709443
    [Abstract] [Full Text] [Related]

  • 11. Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis.
    Xu GY, Winston JH, Shenoy M, Yin H, Pendyala S, Pasricha PJ.
    Gastroenterology; 2007 Oct 05; 133(4):1282-92. PubMed ID: 17698068
    [Abstract] [Full Text] [Related]

  • 12. Effect of chronic inflammation on dorsal horn nociceptive neurons in aged rats.
    Kitagawa J, Kanda K, Sugiura M, Tsuboi Y, Ogawa A, Shimizu K, Koyama N, Kamo H, Watanabe T, Ren K, Iwata K.
    J Neurophysiol; 2005 Jun 05; 93(6):3594-604. PubMed ID: 15659525
    [Abstract] [Full Text] [Related]

  • 13. Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia.
    McDonald HA, Neelands TR, Kort M, Han P, Vos MH, Faltynek CR, Moreland RB, Puttfarcken PS.
    Eur J Pharmacol; 2008 Oct 31; 596(1-3):62-9. PubMed ID: 18755179
    [Abstract] [Full Text] [Related]

  • 14. TRPV1-related modulation of spinal neuronal activity and behavior in a rat model of osteoarthritic pain.
    Chu KL, Chandran P, Joshi SK, Jarvis MF, Kym PR, McGaraughty S.
    Brain Res; 2011 Jan 19; 1369():158-66. PubMed ID: 21047496
    [Abstract] [Full Text] [Related]

  • 15. TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues.
    Baamonde A, Lastra A, Juarez L, Hidalgo A, Menéndez L.
    Brain Res Bull; 2005 Nov 30; 67(6):476-81. PubMed ID: 16216696
    [Abstract] [Full Text] [Related]

  • 16. A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
    Honore P, Wismer CT, Mikusa J, Zhu CZ, Zhong C, Gauvin DM, Gomtsyan A, El Kouhen R, Lee CH, Marsh K, Sullivan JP, Faltynek CR, Jarvis MF.
    J Pharmacol Exp Ther; 2005 Jul 30; 314(1):410-21. PubMed ID: 15837818
    [Abstract] [Full Text] [Related]

  • 17. Upregulation of adrenomedullin in the spinal cord and dorsal root ganglia in the early phase of CFA-induced inflammation in rats.
    Hong Y, Liu Y, Chabot JG, Fournier A, Quirion R.
    Pain; 2009 Nov 30; 146(1-2):105-13. PubMed ID: 19683388
    [Abstract] [Full Text] [Related]

  • 18. Mu-opioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain.
    Endres-Becker J, Heppenstall PA, Mousa SA, Labuz D, Oksche A, Schäfer M, Stein C, Zöllner C.
    Mol Pharmacol; 2007 Jan 30; 71(1):12-8. PubMed ID: 17005903
    [Abstract] [Full Text] [Related]

  • 19. Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: implications for mechanical sensitivity.
    Chu KL, Faltynek CR, Jarvis MF, McGaraughty S.
    Neurosci Lett; 2004 Nov 30; 372(1-2):123-6. PubMed ID: 15531101
    [Abstract] [Full Text] [Related]

  • 20. A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain.
    Xu J, Chu KL, Zhu CZ, Niforatos W, Swensen A, Searle X, Lee L, Jarvis MF, McGaraughty S.
    J Neurophysiol; 2014 Jan 30; 111(2):394-404. PubMed ID: 24155005
    [Abstract] [Full Text] [Related]

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