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Journal Abstract Search

246 related items for PubMed ID: 1617622

  • 1. Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium.
    Chen SF, Perrella FW, Behrens DL, Papp LM.
    Cancer Res; 1992 Jul 01; 52(13):3521-7. PubMed ID: 1617622
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  • 2. Structure-activity relationship of quinoline carboxylic acids. A new class of inhibitors of dihydroorotate dehydrogenase.
    Chen SF, Papp LM, Ardecky RJ, Rao GV, Hesson DP, Forbes M, Dexter DL.
    Biochem Pharmacol; 1990 Aug 15; 40(4):709-14. PubMed ID: 2386542
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  • 3. Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.
    Knecht W, Henseling J, Löffler M.
    Chem Biol Interact; 2000 Jan 03; 124(1):61-76. PubMed ID: 10658902
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  • 4. Differential susceptibility of dihydroorotate dehydrogenase/oxidase to Brequinar Sodium (NSC 368 390) in vitro.
    Lakaschus G, Löffler M.
    Biochem Pharmacol; 1992 Mar 03; 43(5):1025-30. PubMed ID: 1313236
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  • 7. Mechanism of action of the novel anticancer agent 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis.
    Chen SF, Ruben RL, Dexter DL.
    Cancer Res; 1986 Oct 03; 46(10):5014-9. PubMed ID: 3019518
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  • 10. Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.
    Cleaveland ES, Zaharevitz DW, Kelley JA, Paull K, Cooney DA, Ford H.
    Biochem Biophys Res Commun; 1996 Jun 25; 223(3):654-9. PubMed ID: 8687451
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  • 12. The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.
    Walse B, Dufe VT, Svensson B, Fritzson I, Dahlberg L, Khairoullina A, Wellmar U, Al-Karadaghi S.
    Biochemistry; 2008 Aug 26; 47(34):8929-36. PubMed ID: 18672895
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  • 14. Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).
    Peters GJ, Sharma SL, Laurensse E, Pinedo HM.
    Invest New Drugs; 1987 Aug 26; 5(3):235-44. PubMed ID: 2822596
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  • 15. Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells.
    Knecht W, Altekruse D, Rotgeri A, Gonski S, Löffler M.
    Protein Expr Purif; 1997 Jun 26; 10(1):89-99. PubMed ID: 9179295
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  • 16. Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.
    McLean JE, Neidhardt EA, Grossman TH, Hedstrom L.
    Biochemistry; 2001 Feb 20; 40(7):2194-200. PubMed ID: 11329288
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  • 17. Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans.
    Zameitat E, Gojković Z, Knecht W, Piskur J, Löffler M.
    FEBS J; 2006 Jul 20; 273(14):3183-91. PubMed ID: 16774642
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  • 18. Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects?
    Ullrich A, Knecht W, Fries M, Löffler M.
    Eur J Biochem; 2001 Mar 20; 268(6):1861-8. PubMed ID: 11248707
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  • 19. Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.
    Bader B, Knecht W, Fries M, Löffler M.
    Protein Expr Purif; 1998 Aug 20; 13(3):414-22. PubMed ID: 9693067
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  • 20. Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.
    He T, Haapa-Paananen S, Kaminskyy VO, Kohonen P, Fey V, Zhivotovsky B, Kallioniemi O, Perälä M.
    Oncogene; 2014 Jul 03; 33(27):3538-49. PubMed ID: 24013224
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