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161 related items for PubMed ID: 16195754

  • 1. Gene profiling study of G3139- and Bcl-2-targeting siRNAs identifies a unique G3139 molecular signature.
    Anderson EM, Miller P, Ilsley D, Marshall W, Khvorova A, Stein CA, Benimetskaya L.
    Cancer Gene Ther; 2006 Apr; 13(4):406-14. PubMed ID: 16195754
    [Abstract] [Full Text] [Related]

  • 2. Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma.
    Benimetskaya L, Wittenberger T, Stein CA, Hofmann HP, Weller C, Lai JC, Miller P, Gekeler V.
    Clin Cancer Res; 2004 Jun 01; 10(11):3678-88. PubMed ID: 15173074
    [Abstract] [Full Text] [Related]

  • 3. Bcl-2 protein in 518A2 melanoma cells in vivo and in vitro.
    Benimetskaya L, Ayyanar K, Kornblum N, Castanotto D, Rossi J, Wu S, Lai J, Brown BD, Popova N, Miller P, McMicken H, Chen Y, Stein CA.
    Clin Cancer Res; 2006 Aug 15; 12(16):4940-8. PubMed ID: 16914583
    [Abstract] [Full Text] [Related]

  • 4. G3139 induces cell death by caspase-dependent and -independent apoptosis on human melanoma cell lines.
    Nakamura S, Inui M, Kamei T, Nakase M, Okumura K, Tagawa T.
    Oncol Rep; 2006 Jun 15; 15(6):1563-8. PubMed ID: 16685396
    [Abstract] [Full Text] [Related]

  • 5. Induction of apoptosis by G3139 in melanoma cells.
    Benimetskaya L, Lai JC, Khvorova A, Wu S, Miller P, Stein CA.
    Ann N Y Acad Sci; 2005 Nov 15; 1058():235-45. PubMed ID: 16394140
    [Abstract] [Full Text] [Related]

  • 6. Gene expression silencing with 'specific' small interfering RNA goes beyond specificity - a study of key parameters to take into account in the onset of small interfering RNA off-target effects.
    Vankoningsloo S, de Longueville F, Evrard S, Rahier P, Houbion A, Fattaccioli A, Gastellier M, Remacle J, Raes M, Renard P, Arnould T.
    FEBS J; 2008 Jun 15; 275(11):2738-53. PubMed ID: 18422646
    [Abstract] [Full Text] [Related]

  • 7. Efficient delivery of Bcl-2-targeted siRNA using cationic polymer nanoparticles: downregulating mRNA expression level and sensitizing cancer cells to anticancer drug.
    Beh CW, Seow WY, Wang Y, Zhang Y, Ong ZY, Ee PL, Yang YY.
    Biomacromolecules; 2009 Jan 12; 10(1):41-8. PubMed ID: 19072631
    [Abstract] [Full Text] [Related]

  • 8. Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells.
    Huang H, Zegarra-Moro OL, Benson D, Tindall DJ.
    Oncogene; 2004 Mar 18; 23(12):2161-76. PubMed ID: 14676836
    [Abstract] [Full Text] [Related]

  • 9. Small interference RNA targeting heat-shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro.
    Rocchi P, Jugpal P, So A, Sinneman S, Ettinger S, Fazli L, Nelson C, Gleave M.
    BJU Int; 2006 Nov 18; 98(5):1082-9. PubMed ID: 16879439
    [Abstract] [Full Text] [Related]

  • 10. Cellular uptake and intracellular levels of the bcl-2 antisense g3139 in cultured cells and treated patients with acute myeloid leukemia.
    Dai G, Chan KK, Liu S, Hoyt D, Whitman S, Klisovic M, Shen T, Caligiuri MA, Byrd J, Grever M, Marcucci G.
    Clin Cancer Res; 2005 Apr 15; 11(8):2998-3008. PubMed ID: 15837754
    [Abstract] [Full Text] [Related]

  • 11. Off-target effects related to the phosphorothioate modification of nucleic acids.
    Winkler J, Stessl M, Amartey J, Noe CR.
    ChemMedChem; 2010 Aug 02; 5(8):1344-52. PubMed ID: 20544786
    [Abstract] [Full Text] [Related]

  • 12. RNA interference targeting ORC1 gene suppresses the proliferation of vascular smooth muscle cells in rats.
    Shu MQ, Qin YL, Jiang MH.
    Exp Mol Pathol; 2008 Jun 02; 84(3):206-12. PubMed ID: 18499104
    [Abstract] [Full Text] [Related]

  • 13. G3139 antisense oligonucleotide directed against antiapoptotic Bcl-2 enhances doxorubicin cytotoxicity in the FU-SY-1 synovial sarcoma cell line.
    Joyner DE, Albritton KH, Bastar JD, Randall RL.
    J Orthop Res; 2006 Mar 02; 24(3):474-80. PubMed ID: 16450387
    [Abstract] [Full Text] [Related]

  • 14. Effects of small interfering RNAs targeting MAPK1 on gene expression profile in HeLa cells as revealed by microarray analysis.
    Huang C, Liu LY, Li ZF, Wang P, Ni L, Song LP, Xu DH, Song TS.
    Cell Biol Int; 2008 Sep 02; 32(9):1081-90. PubMed ID: 18539490
    [Abstract] [Full Text] [Related]

  • 15. Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes.
    Yaqinuddin A, Abbas F, Naqvi SZ, Bashir MU, Qazi R, Qureshi SA.
    Biosci Rep; 2008 Dec 02; 28(6):319-26. PubMed ID: 18666890
    [Abstract] [Full Text] [Related]

  • 16. Antisense RNA down-regulation of bcl-2 expression in DU145 prostate cancer cells does not diminish the cytostatic effects of G3139 (Oblimersen).
    Raffo A, Lai JC, Stein CA, Miller P, Scaringe S, Khvorova A, Benimetskaya L.
    Clin Cancer Res; 2004 May 01; 10(9):3195-206. PubMed ID: 15131061
    [Abstract] [Full Text] [Related]

  • 17. Ablation of Stat3 by siRNA alters gene expression profiles in JEG-3 cells: a systems biology approach.
    Jiang K, Krous LC, Knowlton N, Chen Y, Frank MB, Cadwell C, Centola M, Jarvis JN.
    Placenta; 2009 Sep 01; 30(9):806-15. PubMed ID: 19616846
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of Bcl-2 expression by a novel tumor-specific RNA interference system increases chemosensitivity to 5-fluorouracil in Hela cells.
    Huang SL, Wu Y, Yu H, Zhang P, Zhang XQ, Ying L, Zhao HF.
    Acta Pharmacol Sin; 2006 Feb 01; 27(2):242-8. PubMed ID: 16412276
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of the proliferation of human gastric cancer cells SGC-7901 in vitro and in vivo using Bcl-2 siRNA.
    Hao JH, Gu QL, Liu BY, Li JF, Chen XH, Ji YB, Zhu ZG, Lin YZ.
    Chin Med J (Engl); 2007 Dec 05; 120(23):2105-11. PubMed ID: 18167184
    [Abstract] [Full Text] [Related]

  • 20. Bcl-2 targeting siRNA expressed by a T7 vector system inhibits human tumor cell growth in vitro.
    Holle L, Hicks L, Song W, Holle E, Wagner T, Yu X.
    Int J Oncol; 2004 Mar 05; 24(3):615-21. PubMed ID: 14767546
    [Abstract] [Full Text] [Related]

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