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517 related items for PubMed ID: 16272756

  • 1. Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.
    Kimura N, Masuda S, Tanihara Y, Ueo H, Okuda M, Katsura T, Inui K.
    Drug Metab Pharmacokinet; 2005 Oct; 20(5):379-86. PubMed ID: 16272756
    [Abstract] [Full Text] [Related]

  • 2. Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure.
    Komazawa H, Yamaguchi H, Hidaka K, Ogura J, Kobayashi M, Iseki K.
    J Pharm Sci; 2013 Mar; 102(3):1086-94. PubMed ID: 23280877
    [Abstract] [Full Text] [Related]

  • 3. Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations.
    König J, Zolk O, Singer K, Hoffmann C, Fromm MF.
    Br J Pharmacol; 2011 Jun; 163(3):546-55. PubMed ID: 20883471
    [Abstract] [Full Text] [Related]

  • 4. Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies.
    Zhang G, Ma Y, Xi D, Rao Z, Sun X, Wu X.
    Biopharm Drug Dispos; 2019 Jan; 40(1):3-11. PubMed ID: 30488476
    [Abstract] [Full Text] [Related]

  • 5. In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1.
    Li L, Song F, Tu M, Wang K, Zhao L, Wu X, Zhou H, Xia Z, Jiang H.
    Int J Pharm; 2014 Apr 25; 465(1-2):5-10. PubMed ID: 24530383
    [Abstract] [Full Text] [Related]

  • 6. Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
    Nishizawa K, Yoda N, Morokado F, Komori H, Nakanishi T, Tamai I.
    PLoS One; 2019 Apr 25; 14(4):e0214862. PubMed ID: 30951542
    [Abstract] [Full Text] [Related]

  • 7. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
    Ito S, Kusuhara H, Yokochi M, Toyoshima J, Inoue K, Yuasa H, Sugiyama Y.
    J Pharmacol Exp Ther; 2012 Feb 25; 340(2):393-403. PubMed ID: 22072731
    [Abstract] [Full Text] [Related]

  • 8. The Nonmetabolized β-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1B1 and OATP1B3.
    Misaka S, Knop J, Singer K, Hoier E, Keiser M, Müller F, Glaeser H, König J, Fromm MF.
    Mol Pharm; 2016 Feb 01; 13(2):512-9. PubMed ID: 26702643
    [Abstract] [Full Text] [Related]

  • 9. Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).
    Nies AT, Herrmann E, Brom M, Keppler D.
    Naunyn Schmiedebergs Arch Pharmacol; 2008 Feb 01; 376(6):449-61. PubMed ID: 18157518
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  • 11. Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin.
    Shikata E, Yamamoto R, Takane H, Shigemasa C, Ikeda T, Otsubo K, Ieiri I.
    J Hum Genet; 2007 Feb 01; 52(2):117-122. PubMed ID: 17111267
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  • 13. Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.
    Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH.
    Mol Cell Biol; 2003 Nov 01; 23(21):7902-8. PubMed ID: 14560032
    [Abstract] [Full Text] [Related]

  • 14. Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake.
    Choi MK, Song IS.
    Biopharm Drug Dispos; 2012 Apr 01; 33(3):170-8. PubMed ID: 22415520
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  • 16. Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patients.
    Jung N, Lehmann C, Rubbert A, Schömig E, Fätkenheuer G, Hartmann P, Taubert D.
    Infection; 2013 Apr 01; 41(2):379-85. PubMed ID: 22875535
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  • 17. Renal organic cation and nucleoside transport.
    Chen R, Jonker JW, Nelson JA.
    Biochem Pharmacol; 2002 Jul 15; 64(2):185-90. PubMed ID: 12123738
    [Abstract] [Full Text] [Related]

  • 18. Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin.
    Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y.
    J Pharmacol Exp Ther; 2002 Aug 15; 302(2):510-5. PubMed ID: 12130709
    [Abstract] [Full Text] [Related]

  • 19. Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.
    Higgins JW, Bedwell DW, Zamek-Gliszczynski MJ.
    Drug Metab Dispos; 2012 Jun 15; 40(6):1170-7. PubMed ID: 22407892
    [Abstract] [Full Text] [Related]

  • 20. Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant.
    Minematsu T, Iwai M, Umehara K, Usui T, Kamimura H.
    Drug Metab Dispos; 2010 Jan 15; 38(1):1-4. PubMed ID: 19833842
    [Abstract] [Full Text] [Related]

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