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Journal Abstract Search

1521 related items for PubMed ID: 16274259

  • 1. Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.
    Babizhayev MA.
    Drugs R D; 2005; 6(6):345-69. PubMed ID: 16274259
    [Abstract] [Full Text] [Related]

  • 2. Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.
    Babizhayev MA.
    Drug Metabol Drug Interact; 2009; 24(2-4):275-323. PubMed ID: 20408504
    [Abstract] [Full Text] [Related]

  • 3. State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
    Babizhayev MA, Kasus-Jacobi A.
    Curr Clin Pharmacol; 2009 Jan; 4(1):4-37. PubMed ID: 19149498
    [Abstract] [Full Text] [Related]

  • 4. Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease.
    Babizhayev MA.
    Cell Biochem Funct; 2011 Apr; 29(3):183-206. PubMed ID: 21381059
    [Abstract] [Full Text] [Related]

  • 5. Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.
    Babizhayev MA, Yegorov YE.
    Recent Pat Drug Deliv Formul; 2016 Apr; 10(2):82-129. PubMed ID: 26084629
    [Abstract] [Full Text] [Related]

  • 6. Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes.
    Babizhayev MA, Deyev AI, Yermakova VN, Brikman IV, Bours J.
    Drugs R D; 2004 Apr; 5(3):125-39. PubMed ID: 15139774
    [Abstract] [Full Text] [Related]

  • 7. N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population.
    Babizhayev MA, Burke L, Micans P, Richer SP.
    Clin Interv Aging; 2009 Apr; 4():31-50. PubMed ID: 19503764
    [Abstract] [Full Text] [Related]

  • 8. Ocular drug metabolism of the bioactivating antioxidant N-acetylcarnosine for vision in ophthalmic prodrug and codrug design and delivery.
    Babizhayev MA.
    Drug Dev Ind Pharm; 2008 Oct; 34(10):1071-89. PubMed ID: 18777243
    [Abstract] [Full Text] [Related]

  • 9. N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients.
    Babizhayev MA, Micans P, Guiotto A, Kasus-Jacobi A.
    Am J Ther; 2009 Oct; 16(6):517-33. PubMed ID: 19487926
    [Abstract] [Full Text] [Related]

  • 10. The natural histidine-containing dipeptide Nalpha-acetylcarnosine as an antioxidant for ophthalmic use.
    Babizhayev MA, Yermakova VN, Semiletov YA, Deyev AI.
    Biochemistry (Mosc); 2000 May; 65(5):588-98. PubMed ID: 10851037
    [Abstract] [Full Text] [Related]

  • 11. N alpha-acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as antioxidant.
    Babizhayev MA, Yermakova VN, Sakina NL, Evstigneeva RP, Rozhkova EA, Zheltukhina GA.
    Clin Chim Acta; 1996 Oct 15; 254(1):1-21. PubMed ID: 8894306
    [Abstract] [Full Text] [Related]

  • 12. Biomarkers of oxidative stress and cataract. Novel drug delivery therapeutic strategies targeting telomere reduction and the expression of telomerase activity in the lens epithelial cells with N-acetylcarnosine lubricant eye drops: anti-cataract which helps to prevent and treat cataracts in the eyes of dogs and other animals.
    Babizhayev MA, Yegorov YE.
    Curr Drug Deliv; 2014 Oct 15; 11(1):24-61. PubMed ID: 24783234
    [Abstract] [Full Text] [Related]

  • 13. Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform.
    Babizhayev MA.
    Drug Test Anal; 2012 Jun 15; 4(6):468-85. PubMed ID: 21416634
    [Abstract] [Full Text] [Related]

  • 14. Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous.
    Babizhayev MA, Vishnyakova KS, Yegorov YE.
    Fundam Clin Pharmacol; 2011 Apr 15; 25(2):139-62. PubMed ID: 20412312
    [Abstract] [Full Text] [Related]

  • 15. Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine.
    Babizhayev MA.
    Fundam Clin Pharmacol; 2012 Feb 15; 26(1):86-117. PubMed ID: 21883446
    [Abstract] [Full Text] [Related]

  • 16. Failure to withstand oxidative stress induced by phospholipid hydroperoxides as a possible cause of the lens opacities in systemic diseases and ageing.
    Babizhayev MA.
    Biochim Biophys Acta; 1996 Mar 01; 1315(2):87-99. PubMed ID: 8608175
    [Abstract] [Full Text] [Related]

  • 17. Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products.
    Babizhayev MA.
    Life Sci; 2006 Apr 11; 78(20):2343-57. PubMed ID: 16388826
    [Abstract] [Full Text] [Related]

  • 18. N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications.
    Babizhayev MA, Guiotto A, Kasus-Jacobi A.
    J Drug Target; 2009 Jan 11; 17(1):36-63. PubMed ID: 19037813
    [Abstract] [Full Text] [Related]

  • 19. Novel intraocular and systemic absorption drug delivery and efficacy of N-acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care.
    Babizhayev MA, Khoroshilova-Maslova IP, Kasus-Jacobi A.
    Fundam Clin Pharmacol; 2012 Oct 11; 26(5):644-78. PubMed ID: 21793899
    [Abstract] [Full Text] [Related]

  • 20. Antioxidant activity of L-carnosine, a natural histidine-containing dipeptide in crystalline lens.
    Babizhayev MA.
    Biochim Biophys Acta; 1989 Aug 22; 1004(3):363-71. PubMed ID: 2758030
    [Abstract] [Full Text] [Related]

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