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Journal Abstract Search

271 related items for PubMed ID: 16290930

  • 1. Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure.
    Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellström O, Xue Y.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(4):1032-6. PubMed ID: 16290930
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  • 2. Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles.
    Isaacs RC, Solinsky MG, Cutrona KJ, Newton CL, Naylor-Olsen AM, McMasters DR, Krueger JA, Lewis SD, Lucas BJ, Kuo LC, Yan Y, Lynch JJ, Lyle EA.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):2062-6. PubMed ID: 18291642
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  • 3. Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.
    Isaacs RC, Newton CL, Cutrona KJ, Mercer SP, Payne LS, Stauffer KJ, Williams PD, Cook JJ, Krueger JA, Lewis SD, Lucas BJ, Lyle EA, Lynch JJ, McMasters DR, Naylor-Olsen AM, Michener MT, Wallace AA.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1536-40. PubMed ID: 21295467
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  • 4. Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.
    Hanessian S, Simard D, Bayrakdarian M, Therrien E, Nilsson I, Fjellström O.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1972-6. PubMed ID: 18289852
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  • 7. From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3.
    Dönnecke D, Schweinitz A, Stürzebecher A, Steinmetzer P, Schuster M, Stürzebecher U, Nicklisch S, Stürzebecher J, Steinmetzer T.
    Bioorg Med Chem Lett; 2007 Jun 15; 17(12):3322-9. PubMed ID: 17462889
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  • 10. Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization.
    Deng JZ, McMasters DR, Rabbat PM, Williams PD, Coburn CA, Yan Y, Kuo LC, Lewis SD, Lucas BJ, Krueger JA, Strulovici B, Vacca JP, Lyle TA, Burgey CS.
    Bioorg Med Chem Lett; 2005 Oct 15; 15(20):4411-6. PubMed ID: 16137886
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  • 11. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
    Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R.
    Bioorg Med Chem Lett; 2004 Jul 16; 14(14):3727-31. PubMed ID: 15203151
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  • 13. Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
    Lin J, Deng H, Jin L, Pandey P, Quinn J, Cantin S, Rynkiewicz MJ, Gorga JC, Bibbins F, Celatka CA, Nagafuji P, Bannister TD, Meyers HV, Babine RE, Hayward NJ, Weaver D, Benjamin H, Stassen F, Abdel-Meguid SS, Strickler JE.
    J Med Chem; 2006 Dec 28; 49(26):7781-91. PubMed ID: 17181160
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  • 14. Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.
    Young RJ, Campbell M, Borthwick AD, Brown D, Burns-Kurtis CL, Chan C, Convery MA, Crowe MC, Dayal S, Diallo H, Kelly HA, King NP, Kleanthous S, Mason AM, Mordaunt JE, Patel C, Pateman AJ, Senger S, Shah GP, Smith PW, Watson NS, Weston HE, Zhou P.
    Bioorg Med Chem Lett; 2006 Dec 01; 16(23):5953-7. PubMed ID: 16982190
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  • 15. Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis.
    Lumma WC, Witherup KM, Tucker TJ, Brady SF, Sisko JT, Naylor-Olsen AM, Lewis SD, Lucas BJ, Vacca JP.
    J Med Chem; 1998 Mar 26; 41(7):1011-3. PubMed ID: 9544200
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  • 16. Design, synthesis and structural exploration of novel fluorinated dabigatran derivatives as direct thrombin inhibitors.
    Li ML, Ren YJ, Dong MH, Ren WX.
    Eur J Med Chem; 2015 Mar 26; 96():122-38. PubMed ID: 25874337
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  • 17. Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics.
    Marinko P, Krbavcic A, Mlinsek G, Solmajer T, Bakija AT, Stegnar M, Stojan J, Kikelj D.
    Eur J Med Chem; 2004 Mar 26; 39(3):257-65. PubMed ID: 15051174
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  • 18. Preparation of L-proline based aeruginosin 298-A analogs: optimization of the P1-moiety.
    Wang G, Goyal N, Hopkinson B.
    Bioorg Med Chem Lett; 2009 Jul 15; 19(14):3798-803. PubMed ID: 19447619
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  • 19. Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
    Stürzebecher J, Prasa D, Hauptmann J, Vieweg H, Wikström P.
    J Med Chem; 1997 Sep 12; 40(19):3091-9. PubMed ID: 9301673
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  • 20. Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
    Burgey CS, Robinson KA, Lyle TA, Sanderson PE, Lewis SD, Lucas BJ, Krueger JA, Singh R, Miller-Stein C, White RB, Wong B, Lyle EA, Williams PD, Coburn CA, Dorsey BD, Barrow JC, Stranieri MT, Holahan MA, Sitko GR, Cook JJ, McMasters DR, McDonough CM, Sanders WM, Wallace AA, Clayton FC, Bohn D, Leonard YM, Detwiler TJ, Lynch JJ, Yan Y, Chen Z, Kuo L, Gardell SJ, Shafer JA, Vacca JP.
    J Med Chem; 2003 Feb 13; 46(4):461-73. PubMed ID: 12570369
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