These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

439 related items for PubMed ID: 16290933

  • 1. Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.
    Masterson LA, Spanswick VJ, Hartley JA, Begent RH, Howard PW, Thurston DE.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):252-6. PubMed ID: 16290933
    [Abstract] [Full Text] [Related]

  • 2. Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.
    Niculescu-Duvaz I, Scanlon I, Niculescu-Duvaz D, Friedlos F, Martin J, Marais R, Springer CJ.
    J Med Chem; 2004 May 06; 47(10):2651-8. PubMed ID: 15115406
    [Abstract] [Full Text] [Related]

  • 3. Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy.
    Davies LC, Friedlos F, Hedley D, Martin J, Ogilvie LM, Scanlon IJ, Springer CJ.
    J Med Chem; 2005 Aug 11; 48(16):5321-8. PubMed ID: 16078849
    [Abstract] [Full Text] [Related]

  • 4. Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
    Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer CJ.
    J Med Chem; 1998 Dec 17; 41(26):5297-309. PubMed ID: 9857097
    [Abstract] [Full Text] [Related]

  • 5. Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.
    Khan TH, Eno-Amooquaye EA, Searle F, Browne PJ, Osborn HM, Burke PJ.
    J Med Chem; 1999 Mar 25; 42(6):951-6. PubMed ID: 10090777
    [Abstract] [Full Text] [Related]

  • 6. Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma.
    Napier MP, Sharma SK, Springer CJ, Bagshawe KD, Green AJ, Martin J, Stribbling SM, Cushen N, O'Malley D, Begent RH.
    Clin Cancer Res; 2000 Mar 25; 6(3):765-72. PubMed ID: 10741695
    [Abstract] [Full Text] [Related]

  • 7. Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs.
    Springer CJ, Niculescu-Duvaz I.
    Anticancer Drug Des; 1995 Jul 25; 10(5):361-72. PubMed ID: 7639927
    [Abstract] [Full Text] [Related]

  • 8. New mustard prodrugs for antibody-directed enzyme prodrug therapy: alternatives to the amide link.
    Dowell RI, Springer CJ, Davies DH, Hadley EM, Burke PJ, Boyle FT, Melton RG, Connors TA, Blakey DC, Mauger AB.
    J Med Chem; 1996 Mar 01; 39(5):1100-5. PubMed ID: 8676345
    [Abstract] [Full Text] [Related]

  • 9.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 10. Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT).
    Springer CJ, Dowell R, Burke PJ, Hadley E, Davis DH, Blakey DC, Melton RG, Niculescu-Duvaz I.
    J Med Chem; 1995 Dec 22; 38(26):5051-65. PubMed ID: 8544182
    [Abstract] [Full Text] [Related]

  • 11. Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.
    Kamal A, Tekumalla V, Krishnan A, Pal-Bhadra M, Bhadra U.
    ChemMedChem; 2008 May 22; 3(5):794-802. PubMed ID: 18247436
    [Abstract] [Full Text] [Related]

  • 12. Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
    Howard PW, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Cooper N, Fang M, Coffils MJ, Klee S, Hartley JA, Thurston DE.
    Bioorg Med Chem Lett; 2009 Nov 15; 19(22):6463-6. PubMed ID: 19811912
    [Abstract] [Full Text] [Related]

  • 13.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 14.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 15. Self-immolative anthracycline prodrugs for suicide gene therapy.
    Niculescu-Duvaz I, Niculescu-Duvaz D, Friedlos F, Spooner R, Martin J, Marais R, Springer CJ.
    J Med Chem; 1999 Jul 01; 42(13):2485-9. PubMed ID: 10395490
    [Abstract] [Full Text] [Related]

  • 16. Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.
    Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Lehouritis P, Marais R, Springer CJ.
    J Med Chem; 2003 Apr 24; 46(9):1690-705. PubMed ID: 12699387
    [Abstract] [Full Text] [Related]

  • 17.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 18. Development of pyrrolo[2,1-c][1,4]benzodiazepine β-glucoside prodrugs for selective therapy of cancer.
    Adiyala PR, Tekumalla V, Sayeed IB, Nayak VL, Nagarajan A, Shareef MA, Nagaraju B, Kamal A.
    Bioorg Chem; 2018 Feb 24; 76():288-293. PubMed ID: 29223805
    [Abstract] [Full Text] [Related]

  • 19. A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy.
    Marais R, Spooner RA, Stribbling SM, Light Y, Martin J, Springer CJ.
    Nat Biotechnol; 1997 Dec 24; 15(13):1373-7. PubMed ID: 9415889
    [Abstract] [Full Text] [Related]

  • 20.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 22.