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Journal Abstract Search

194 related items for PubMed ID: 16309911

  • 1. Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part 1: design and synthesis of a lead compound exhibiting alpha(v)beta3/alpha(IIb)beta3 dual antagonistic activity.
    Kubota D, Ishikawa M, Yamamoto M, Murakami S, Hachisu M, Katano K, Ajito K.
    Bioorg Med Chem; 2006 Apr 01; 14(7):2089-108. PubMed ID: 16309911
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  • 2. Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part III: synthesis of potent antagonists with alpha(v)beta3/alpha(IIb)beta3 dual activity and improved water solubility.
    Ishikawa M, Hiraiwa Y, Kubota D, Tsushima M, Watanabe T, Murakami S, Ouchi S, Ajito K.
    Bioorg Med Chem; 2006 Apr 01; 14(7):2131-50. PubMed ID: 16307881
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  • 3. Tricyclic pharmacophore-based molecules as novel integrin alpha(v)beta3 antagonists. Part 2: synthesis of potent alpha(v)beta3/alpha(IIb)beta3 dual antagonists.
    Ishikawa M, Kubota D, Yamamoto M, Kuroda C, Iguchi M, Koyanagi A, Murakami S, Ajito K.
    Bioorg Med Chem; 2006 Apr 01; 14(7):2109-30. PubMed ID: 16309912
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  • 4. Tricyclic pharmacophore-based molecules as novel integrin alphavbeta3 antagonists. Part IV: preliminary control of alphavbeta3 selectivity by meta-oriented substitution.
    Kubota D, Ishikawa M, Ishikawa M, Yahata N, Murakami S, Fujishima K, Kitakaze M, Ajito K.
    Bioorg Med Chem; 2006 Jun 15; 14(12):4158-81. PubMed ID: 16504518
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  • 5. Studies of tricyclic piperazine/piperidine furnished molecules as novel integrin αvβ3/αIIbβ3 dual antagonists using 3D-QSAR and molecular docking.
    Yan Y, Li Y, Zhang S, Ai C.
    J Mol Graph Model; 2011 Feb 15; 29(5):747-62. PubMed ID: 21273104
    [Abstract] [Full Text] [Related]

  • 6. Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study.
    Anderluh M, Cesar J, Stefanic P, Kikelj D, Janes D, Murn J, Nadrah K, Tominc M, Addicks E, Giannis A, Stegnar M, Dolenc MS.
    Eur J Med Chem; 2005 Jan 15; 40(1):25-49. PubMed ID: 15642407
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  • 8. A peptidomimetic antagonist of the integrin alpha(v)beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy.
    Carron CP, Meyer DM, Pegg JA, Engleman VW, Nickols MA, Settle SL, Westlin WF, Ruminski PG, Nickols GA.
    Cancer Res; 1998 May 01; 58(9):1930-5. PubMed ID: 9581835
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  • 9. Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins.
    De Corte BL, Kinney WA, Liu L, Ghosh S, Brunner L, Hoekstra WJ, Santulli RJ, Tuman RW, Baker J, Burns C, Proost JC, Tounge BA, Damiano BP, Maryanoff BE, Johnson DL, Galemmo RA.
    Bioorg Med Chem Lett; 2004 Oct 18; 14(20):5227-32. PubMed ID: 15380233
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  • 10. N-Aryl-gamma-lactams as integrin alphavbeta3 antagonists.
    Xi N, Arvedson S, Eisenberg S, Han N, Handley M, Huang L, Huang Q, Kiselyov A, Liu Q, Lu Y, Nunez G, Osslund T, Powers D, Tasker AS, Wang L, Xiang T, Xu S, Zhang J, Zhu J, Kendall R, Dominguez C.
    Bioorg Med Chem Lett; 2004 Jun 07; 14(11):2905-9. PubMed ID: 15125957
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  • 11. Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.
    Sall DJ, Arfsten AE, Bastian JA, Denney ML, Harms CS, McCowan JR, Morin JM, Rose JW, Scarborough RM, Smyth MS, Um SL, Utterback BG, Vasileff RT, Wikel JH, Wyss VL, Jakubowski JA.
    J Med Chem; 1997 Aug 29; 40(18):2843-57. PubMed ID: 9288166
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  • 12. Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.
    Raboisson P, Desjarlais RL, Reed R, Lattanze J, Chaikin M, Manthey CL, Tomczuk BE, Marugán JJ.
    Eur J Med Chem; 2007 Mar 29; 42(3):334-43. PubMed ID: 17184884
    [Abstract] [Full Text] [Related]

  • 13. Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists.
    Boys ML, Schretzman LA, Chandrakumar NS, Tollefson MB, Mohler SB, Downs VL, Penning TD, Russell MA, Wendt JA, Chen BB, Stenmark HG, Wu H, Spangler DP, Clare M, Desai BN, Khanna IK, Nguyen MN, Duffin T, Engleman VW, Finn MB, Freeman SK, Hanneke ML, Keene JL, Klover JA, Nickols GA, Nickols MA, Steininger CN, Westlin M, Westlin W, Yu YX, Wang Y, Dalton CR, Norring SA.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(4):839-44. PubMed ID: 16298127
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  • 15. Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.
    Su T, Naughton MA, Smyth MS, Rose JW, Arfsten AE, McCowan JR, Jakubowski JA, Wyss VL, Ruterbories KJ, Sall DJ, Scarborough RM.
    J Med Chem; 1997 Dec 19; 40(26):4308-18. PubMed ID: 9435900
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  • 20. Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists.
    Penning TD, Khilevich A, Chen BB, Russell MA, Boys ML, Wang Y, Duffin T, Engleman VW, Finn MB, Freeman SK, Hanneke ML, Keene JL, Klover JA, Nickols GA, Nickols MA, Rader RK, Settle SL, Shannon KE, Steininger CN, Westlin MM, Westlin WF.
    Bioorg Med Chem Lett; 2006 Jun 15; 16(12):3156-61. PubMed ID: 16621534
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