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230 related items for PubMed ID: 16361248

  • 1. Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome.
    Gong Q, Jones MA, Zhou Z.
    J Biol Chem; 2006 Feb 17; 281(7):4069-74. PubMed ID: 16361248
    [Abstract] [Full Text] [Related]

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  • 3. Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects.
    Zhou Z, Gong Q, January CT.
    J Biol Chem; 1999 Oct 29; 274(44):31123-6. PubMed ID: 10531299
    [Abstract] [Full Text] [Related]

  • 4. Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER.
    Smith JL, McBride CM, Nataraj PS, Bartos DC, January CT, Delisle BP.
    Am J Physiol Cell Physiol; 2011 Jul 29; 301(1):C75-85. PubMed ID: 21490315
    [Abstract] [Full Text] [Related]

  • 5. The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.
    Ficker E, Obejero-Paz CA, Zhao S, Brown AM.
    J Biol Chem; 2002 Feb 15; 277(7):4989-98. PubMed ID: 11741928
    [Abstract] [Full Text] [Related]

  • 6. Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.
    Keller SH, Platoshyn O, Yuan JX.
    Cell Biochem Biophys; 2005 Feb 15; 43(3):365-77. PubMed ID: 16244363
    [Abstract] [Full Text] [Related]

  • 7. Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C.
    Delisle BP, Anderson CL, Balijepalli RC, Anson BD, Kamp TJ, January CT.
    J Biol Chem; 2003 Sep 12; 278(37):35749-54. PubMed ID: 12837749
    [Abstract] [Full Text] [Related]

  • 8. Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum.
    Wang Y, Huang X, Zhou J, Yang X, Li D, Mao H, Sun HH, Liu N, Lian J.
    PLoS One; 2012 Sep 12; 7(1):e29885. PubMed ID: 22242185
    [Abstract] [Full Text] [Related]

  • 9. Rescue of expression and function of long QT syndrome-causing mutant hERG channels by enhancing channel stability in the plasma membrane.
    Davis J, Cornwell JD, Campagna N, Guo J, Li W, Yang T, Wang T, Zhang S.
    J Biol Chem; 2024 Aug 12; 300(8):107526. PubMed ID: 38960041
    [Abstract] [Full Text] [Related]

  • 10. Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum.
    Smith JL, Reloj AR, Nataraj PS, Bartos DC, Schroder EA, Moss AJ, Ohno S, Horie M, Anderson CL, January CT, Delisle BP.
    Am J Physiol Cell Physiol; 2013 Nov 01; 305(9):C919-30. PubMed ID: 23864605
    [Abstract] [Full Text] [Related]

  • 11. Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block.
    Rajamani S, Anderson CL, Anson BD, January CT.
    Circulation; 2002 Jun 18; 105(24):2830-5. PubMed ID: 12070109
    [Abstract] [Full Text] [Related]

  • 12. Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation.
    Mihic A, Chauhan VS, Gao X, Oudit GY, Tsushima RG.
    PLoS One; 2011 Mar 31; 6(3):e18273. PubMed ID: 21483829
    [Abstract] [Full Text] [Related]

  • 13. Properties of WT and mutant hERG K(+) channels expressed in neonatal mouse cardiomyocytes.
    Lin EC, Holzem KM, Anson BD, Moungey BM, Balijepalli SY, Tester DJ, Ackerman MJ, Delisle BP, Balijepalli RC, January CT.
    Am J Physiol Heart Circ Physiol; 2010 Jun 31; 298(6):H1842-9. PubMed ID: 20363883
    [Abstract] [Full Text] [Related]

  • 14. Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channels.
    Gianulis EC, Trudeau MC.
    J Biol Chem; 2011 Jun 24; 286(25):22160-9. PubMed ID: 21536673
    [Abstract] [Full Text] [Related]

  • 15. Identification of a COOH-terminal segment involved in maturation and stability of human ether-a-go-go-related gene potassium channels.
    Akhavan A, Atanasiu R, Shrier A.
    J Biol Chem; 2003 Oct 10; 278(41):40105-12. PubMed ID: 12885765
    [Abstract] [Full Text] [Related]

  • 16. HERG-F463L potassium channels linked to long QT syndrome reduce I(Kr) current by a trafficking-deficient mechanism.
    Yang HT, Sun CF, Cui CC, Xue XL, Zhang AF, Li HB, Wang DQ, Shu J.
    Clin Exp Pharmacol Physiol; 2009 Aug 10; 36(8):822-7. PubMed ID: 19215240
    [Abstract] [Full Text] [Related]

  • 17. Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome.
    Ficker E, Dennis AT, Obejero-Paz CA, Castaldo P, Taglialatela M, Brown AM.
    J Mol Cell Cardiol; 2000 Dec 10; 32(12):2327-37. PubMed ID: 11113008
    [Abstract] [Full Text] [Related]

  • 18. Defective assembly and trafficking of mutant HERG channels with C-terminal truncations in long QT syndrome.
    Gong Q, Keeney DR, Robinson JC, Zhou Z.
    J Mol Cell Cardiol; 2004 Dec 10; 37(6):1225-33. PubMed ID: 15572053
    [Abstract] [Full Text] [Related]

  • 19. Mutant hERG channel traffic jam. Focus on "Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum".
    Ayon RJ, Fernandez RA, Yuan JX.
    Am J Physiol Cell Physiol; 2013 Nov 01; 305(9):C916-8. PubMed ID: 23986200
    [No Abstract] [Full Text] [Related]

  • 20. HERG trafficking and pharmacological rescue of LQTS-2 mutant channels.
    Robertson GA, January CT.
    Handb Exp Pharmacol; 2006 Nov 01; (171):349-55. PubMed ID: 16610352
    [Abstract] [Full Text] [Related]

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