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Journal Abstract Search

161 related items for PubMed ID: 16420049

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  • 3. Determination of the binding mode of thienopyrimidinedione antagonists to the human gonadotropin releasing hormone receptor using structure-activity relationships, site-directed mutagenesis, and homology modeling.
    Betz SF, Lio FM, Gao Y, Reinhart GJ, Guo Z, Mesleh MF, Zhu YF, Struthers RS.
    J Med Chem; 2006 Oct 19; 49(21):6170-6. PubMed ID: 17034124
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  • 6. Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism.
    Sullivan SK, Hoare SR, Fleck BA, Zhu YF, Heise CE, Struthers RS, Crowe PD.
    Biochem Pharmacol; 2006 Sep 28; 72(7):838-49. PubMed ID: 16930559
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  • 7. Challenges and opportunities of trapping ligands.
    Szkudlinski MW.
    Mol Pharmacol; 2007 Aug 28; 72(2):231-4. PubMed ID: 17522183
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  • 9. Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists.
    Hoare SR, Sullivan SK, Schwarz DA, Ling N, Vale WW, Crowe PD, Grigoriadis DE.
    Biochemistry; 2004 Apr 06; 43(13):3996-4011. PubMed ID: 15049707
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  • 10. Mapping the binding site of six nonpeptide antagonists to the human V2-renal vasopressin receptor.
    Macion-Dazard R, Callahan N, Xu Z, Wu N, Thibonnier M, Shoham M.
    J Pharmacol Exp Ther; 2006 Feb 06; 316(2):564-71. PubMed ID: 16234409
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  • 15. Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902.
    Struthers RS, Xie Q, Sullivan SK, Reinhart GJ, Kohout TA, Zhu YF, Chen C, Liu XJ, Ling N, Yang W, Maki RA, Bonneville AK, Chen TK, Bozigian HP.
    Endocrinology; 2007 Feb 06; 148(2):857-67. PubMed ID: 17095587
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  • 16. GnRHs and GnRH receptors.
    Millar RP.
    Anim Reprod Sci; 2005 Aug 06; 88(1-2):5-28. PubMed ID: 16140177
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  • 17. 3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.
    Tucci FC, Zhu YF, Struthers RS, Guo Z, Gross TD, Rowbottom MW, Acevedo O, Gao Y, Saunders J, Xie Q, Reinhart GJ, Liu XJ, Ling N, Bonneville AK, Chen T, Bozigian H, Chen C.
    J Med Chem; 2005 Feb 24; 48(4):1169-78. PubMed ID: 15715483
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  • 18. Peptide/benzodiazepine hybrids as ligands of CCK(A) and CCK(B) receptors.
    Escherich A, Lutz J, Escrieut C, Fourmy D, van Neuren AS, Müller G, Schafferhans A, Klebe G, Moroder L.
    Biopolymers; 2005 Feb 24; 56(2):55-76. PubMed ID: 11592053
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  • 20. Extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 of the mammalian type I and type II gonadotropin-releasing hormone (GnRH) receptors determine differential ligand selectivity to GnRH-I and GnRH-II.
    Li JH, Choe H, Wang AF, Maiti K, Wang C, Salam A, Chun SY, Lee WK, Kim K, Kwon HB, Seong JY.
    Mol Pharmacol; 2005 Apr 24; 67(4):1099-110. PubMed ID: 15635044
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