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133 related items for PubMed ID: 16432914

  • 1. Roles of phenylalanine at position 120 and glutamic acid at position 222 in the oxidation of chiral substrates by cytochrome P450 2D6.
    Masuda K, Tamagake K, Katsu T, Torigoe F, Saito K, Hanioka N, Yamano S, Yamamoto S, Narimatsu S.
    Chirality; 2006 Feb; 18(3):167-76. PubMed ID: 16432914
    [Abstract] [Full Text] [Related]

  • 2. Change in enantioselectivity in bufuralol 1''-hydroxylation by the substitution of phenylalanine-120 by alanine in cytochrome P450 2D6.
    Masuda K, Tamagake K, Okuda Y, Torigoe F, Tsuzuki D, Isobe T, Hichiya H, Hanioka N, Yamamoto S, Narimatsu S.
    Chirality; 2005 Jan; 17(1):37-43. PubMed ID: 15526337
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  • 3. Enantioselectivity of bunitrolol 4-hydroxylation is reversed by the change of an amino acid residue from valine to methionine at position 374 of cytochrome P450-2D6.
    Narimatsu S, Kato R, Horie T, Ono S, Tsutsui M, Yabusaki Y, Ohmori S, Kitada M, Ichioka T, Shimada N, Kato R, Ishikawa T.
    Chirality; 1999 Jan; 11(1):1-9. PubMed ID: 9914647
    [Abstract] [Full Text] [Related]

  • 4. The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent.
    Lussenburg BM, Keizers PH, de Graaf C, Hidestrand M, Ingelman-Sundberg M, Vermeulen NP, Commandeur JN.
    Biochem Pharmacol; 2005 Oct 15; 70(8):1253-61. PubMed ID: 16135359
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  • 5. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.
    Ellis SW, Hayhurst GP, Lightfoot T, Smith G, Harlow J, Rowland-Yeo K, Larsson C, Mahling J, Lim CK, Wolf CR, Blackburn MG, Lennard MS, Tucker GT.
    Biochem J; 2000 Feb 01; 345 Pt 3(Pt 3):565-71. PubMed ID: 10642515
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  • 6. Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
    Guengerich FP, Hanna IH, Martin MV, Gillam EM.
    Biochemistry; 2003 Feb 11; 42(5):1245-53. PubMed ID: 12564927
    [Abstract] [Full Text] [Related]

  • 7. Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.
    Keizers PH, Lussenburg BM, de Graaf C, Mentink LM, Vermeulen NP, Commandeur JN.
    Biochem Pharmacol; 2004 Dec 01; 68(11):2263-71. PubMed ID: 15498516
    [Abstract] [Full Text] [Related]

  • 8. Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
    Flanagan JU, Maréchal JD, Ward R, Kemp CA, McLaughlin LA, Sutcliffe MJ, Roberts GC, Paine MJ, Wolf CR.
    Biochem J; 2004 Jun 01; 380(Pt 2):353-60. PubMed ID: 14992686
    [Abstract] [Full Text] [Related]

  • 9. Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s.
    Narimatsu S, Takemi C, Kuramoto S, Tsuzuki D, Hichiya H, Tamagake K, Yamamoto S.
    Chirality; 2003 May 05; 15(4):333-9. PubMed ID: 12666241
    [Abstract] [Full Text] [Related]

  • 10. Regio- and stereoselective oxidation of propranolol enantiomers by human CYP2D6, cynomolgus monkey CYP2D17 and marmoset CYP2D19.
    Narimatsu S, Nakata T, Shimizudani T, Nagaoka K, Nakura H, Masuda K, Katsu T, Koeda A, Naito S, Yamano S, Miyata A, Hanioka N.
    Chem Biol Interact; 2011 Feb 01; 189(3):146-52. PubMed ID: 21184751
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  • 13. Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity.
    Hanna IH, Kim MS, Guengerich FP.
    Arch Biochem Biophys; 2001 Sep 15; 393(2):255-61. PubMed ID: 11556812
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  • 14. Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.
    Hayhurst GP, Harlow J, Chowdry J, Gross E, Hilton E, Lennard MS, Tucker GT, Ellis SW.
    Biochem J; 2001 Apr 15; 355(Pt 2):373-9. PubMed ID: 11284724
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  • 17. Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.
    Domanski TL, He YA, Harlow GR, Halpert JR.
    J Pharmacol Exp Ther; 2000 May 15; 293(2):585-91. PubMed ID: 10773032
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  • 18. Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation.
    Geier M, Braun A, Fladischer P, Stepniak P, Rudroff F, Hametner C, Mihovilovic MD, Glieder A.
    FEBS J; 2013 Jul 15; 280(13):3094-108. PubMed ID: 23552177
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  • 19. Novel binding mode of the acidic CYP2D6 substrates pactimibe and its metabolite R-125528.
    Kotsuma M, Hanzawa H, Iwata Y, Takahashi K, Tokui T.
    Drug Metab Dispos; 2008 Sep 15; 36(9):1938-43. PubMed ID: 18524873
    [Abstract] [Full Text] [Related]

  • 20. Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
    Guengerich FP, Miller GP, Hanna IH, Martin MV, Léger S, Black C, Chauret N, Silva JM, Trimble LA, Yergey JA, Nicoll-Griffith DA.
    Biochemistry; 2002 Sep 10; 41(36):11025-34. PubMed ID: 12206675
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