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Journal Abstract Search

171 related items for PubMed ID: 16443666

  • 1. Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes.
    Lu C, Gallegos R, Li P, Xia CQ, Pusalkar S, Uttamsingh V, Nix D, Miwa GT, Gan LS.
    Drug Metab Dispos; 2006 Apr; 34(4):702-8. PubMed ID: 16443666
    [Abstract] [Full Text] [Related]

  • 2. Oxidative deboronation of the peptide boronic acid proteasome inhibitor bortezomib: contributions from reactive oxygen species in this novel cytochrome P450 reaction.
    Labutti J, Parsons I, Huang R, Miwa G, Gan LS, Daniels JS.
    Chem Res Toxicol; 2006 Apr; 19(4):539-46. PubMed ID: 16608165
    [Abstract] [Full Text] [Related]

  • 3. Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites.
    Pekol T, Daniels JS, Labutti J, Parsons I, Nix D, Baronas E, Hsieh F, Gan LS, Miwa G.
    Drug Metab Dispos; 2005 Jun; 33(6):771-7. PubMed ID: 15764713
    [Abstract] [Full Text] [Related]

  • 4. Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib.
    Uttamsingh V, Lu C, Miwa G, Gan LS.
    Drug Metab Dispos; 2005 Nov; 33(11):1723-8. PubMed ID: 16103134
    [Abstract] [Full Text] [Related]

  • 5. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [Abstract] [Full Text] [Related]

  • 6. The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro.
    Poulaki V, Mitsiades CS, Kotoula V, Negri J, McMillin D, Miller JW, Mitsiades N.
    Invest Ophthalmol Vis Sci; 2007 Oct; 48(10):4706-19. PubMed ID: 17898295
    [Abstract] [Full Text] [Related]

  • 7. In vitro metabolism of chlorotriazines: characterization of simazine, atrazine, and propazine metabolism using liver microsomes from rats treated with various cytochrome P450 inducers.
    Hanioka N, Jinno H, Tanaka-Kagawa T, Nishimura T, Ando M.
    Toxicol Appl Pharmacol; 1999 May 01; 156(3):195-205. PubMed ID: 10222312
    [Abstract] [Full Text] [Related]

  • 8. In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.
    Hong H, Su H, Ma L, Yao M, Iyer RA, Humphreys WG, Christopher LJ.
    Drug Metab Dispos; 2011 Sep 01; 39(9):1658-67. PubMed ID: 21673131
    [Abstract] [Full Text] [Related]

  • 9. In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol.
    Usmani KA, Hodgson E, Rose RL.
    Chem Biol Interact; 2004 Dec 07; 150(3):221-32. PubMed ID: 15560889
    [Abstract] [Full Text] [Related]

  • 10. In vitro metabolism of L-696,229, an HIV-1 reverse transcriptase inhibitor in rats and humans. Hepatic and extrahepatic metabolism and identification of enzymes involved in the hepatic metabolism.
    Prueksaritanont T, Dwyer LM, Balani SK, Theoharides AD.
    Drug Metab Dispos; 1994 Dec 07; 22(2):281-8. PubMed ID: 7516854
    [Abstract] [Full Text] [Related]

  • 11. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
    Reilly CA, Ehlhardt WJ, Jackson DA, Kulanthaivel P, Mutlib AE, Espina RJ, Moody DE, Crouch DJ, Yost GS.
    Chem Res Toxicol; 2003 Mar 07; 16(3):336-49. PubMed ID: 12641434
    [Abstract] [Full Text] [Related]

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  • 13. The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes.
    Yao HT, Chang YW, Lan SJ, Yeh TK.
    Food Chem Toxicol; 2008 Feb 07; 46(2):645-53. PubMed ID: 17950511
    [Abstract] [Full Text] [Related]

  • 14. Novel metabolites of buprenorphine detected in human liver microsomes and human urine.
    Chang Y, Moody DE, McCance-Katz EF.
    Drug Metab Dispos; 2006 Mar 07; 34(3):440-8. PubMed ID: 16381669
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  • 16. In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions.
    Warrington JS, Shader RI, von Moltke LL, Greenblatt DJ.
    Drug Metab Dispos; 2000 Apr 07; 28(4):392-7. PubMed ID: 10725306
    [Abstract] [Full Text] [Related]

  • 17. An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes.
    Nassar AE, King I, Paris BL, Haupt L, Ndikum-Moffor F, Campbell R, Usuki E, Skibbe J, Brobst D, Ogilvie BW, Parkinson A.
    Drug Metab Dispos; 2009 Sep 07; 37(9):1922-30. PubMed ID: 19520774
    [Abstract] [Full Text] [Related]

  • 18. Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma.
    Heider U, von Metzler I, Kaiser M, Rosche M, Sterz J, Rötzer S, Rademacher J, Jakob C, Fleissner C, Kuckelkorn U, Kloetzel PM, Sezer O.
    Eur J Haematol; 2008 Feb 07; 80(2):133-42. PubMed ID: 18005386
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  • 20. Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells.
    Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL.
    Cancer Res; 2008 Aug 15; 68(16):6698-707. PubMed ID: 18701494
    [Abstract] [Full Text] [Related]

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