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552 related items for PubMed ID: 16449657

  • 1. Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis.
    Suizu F, Ryo A, Wulf G, Lim J, Lu KP.
    Mol Cell Biol; 2006 Feb; 26(4):1463-79. PubMed ID: 16449657
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  • 2. Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis.
    Wulf G, Garg P, Liou YC, Iglehart D, Lu KP.
    EMBO J; 2004 Aug 18; 23(16):3397-407. PubMed ID: 15257284
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  • 3. Targeting carcinogenesis: a role for the prolyl isomerase Pin1?
    Lu KP, Suizu F, Zhou XZ, Finn G, Lam P, Wulf G.
    Mol Carcinog; 2006 Jun 18; 45(6):397-402. PubMed ID: 16652378
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  • 7. SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function.
    Chen CH, Chang CC, Lee TH, Luo M, Huang P, Liao PH, Wei S, Li FA, Chen RH, Zhou XZ, Shih HM, Lu KP.
    Cancer Res; 2013 Jul 01; 73(13):3951-62. PubMed ID: 23633483
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  • 8. The prolyl isomerase Pin1 in breast development and cancer.
    Wulf G, Ryo A, Liou YC, Lu KP.
    Breast Cancer Res; 2003 Jul 01; 5(2):76-82. PubMed ID: 12631385
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  • 9. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.
    Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V, Lu KP.
    EMBO J; 2001 Jul 02; 20(13):3459-72. PubMed ID: 11432833
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  • 10. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
    Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP.
    Nature; 2006 Mar 23; 440(7083):528-34. PubMed ID: 16554819
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  • 11. The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.
    Khanal P, Namgoong GM, Kang BS, Woo ER, Choi HS.
    Mol Cancer Ther; 2010 Mar 23; 9(3):606-16. PubMed ID: 20179161
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  • 12. Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer.
    Lingle WL, Lukasiewicz K, Salisbury JL.
    Adv Exp Med Biol; 2005 Mar 23; 570():393-421. PubMed ID: 18727509
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  • 13. Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function.
    Rangasamy V, Mishra R, Sondarva G, Das S, Lee TH, Bakowska JC, Tzivion G, Malter JS, Rana B, Lu KP, Kanthasamy A, Rana A.
    Proc Natl Acad Sci U S A; 2012 May 22; 109(21):8149-54. PubMed ID: 22566623
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  • 16. Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer.
    Ryo A, Liou YC, Lu KP, Wulf G.
    J Cell Sci; 2003 Mar 01; 116(Pt 5):773-83. PubMed ID: 12571275
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  • 17. Role of phosphorylation in determining the backbone dynamics of the serine/threonine-proline motif and Pin1 substrate recognition.
    Schutkowski M, Bernhardt A, Zhou XZ, Shen M, Reimer U, Rahfeld JU, Lu KP, Fischer G.
    Biochemistry; 1998 Apr 21; 37(16):5566-75. PubMed ID: 9548941
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  • 18. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes.
    Liou YC, Ryo A, Huang HK, Lu PJ, Bronson R, Fujimori F, Uchida T, Hunter T, Lu KP.
    Proc Natl Acad Sci U S A; 2002 Feb 05; 99(3):1335-40. PubMed ID: 11805292
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  • 19. Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability.
    Lam PB, Burga LN, Wu BP, Hofstatter EW, Lu KP, Wulf GM.
    Mol Cancer; 2008 Dec 15; 7():91. PubMed ID: 19077306
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  • 20. Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation.
    Shekhar MP, Lyakhovich A, Visscher DW, Heng H, Kondrat N.
    Cancer Res; 2002 Apr 01; 62(7):2115-24. PubMed ID: 11929833
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