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PUBMED FOR HANDHELDS

Journal Abstract Search

135 related items for PubMed ID: 16451050

  • 1. Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity.
    Goto Y, Arai-Otsuki S, Tachibana Y, Ichikawa D, Ozaki S, Takahashi H, Iwasawa Y, Okamoto O, Okuda S, Ohta H, Sagara T.
    J Med Chem; 2006 Feb 09; 49(3):847-9. PubMed ID: 16451050
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  • 2. Design, synthesis, and structure-activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine.
    Yoshizumi T, Miyazoe H, Ito H, Tsujita T, Takahashi H, Asai M, Ozaki S, Ohta H, Okamoto O.
    Bioorg Med Chem Lett; 2008 Jul 01; 18(13):3778-82. PubMed ID: 18515099
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  • 3. A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor.
    Zaveri NT, Jiang F, Olsen CM, Deschamps JR, Parrish D, Polgar W, Toll L.
    J Med Chem; 2004 Jun 03; 47(12):2973-6. PubMed ID: 15163178
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  • 4. Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.
    Trapella C, Fischetti C, Pela' M, Lazzari I, Guerrini R, Calo' G, Rizzi A, Camarda V, Lambert DG, McDonald J, Regoli D, Salvadori S.
    Bioorg Med Chem; 2009 Jul 15; 17(14):5080-95. PubMed ID: 19527931
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  • 5. Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
    Caldwell JP, Matasi JJ, Fernandez X, McLeod RL, Zhang H, Fawzi A, Tulshian DB.
    Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1164-7. PubMed ID: 19147350
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  • 6. Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinical candidate.
    Satoh A, Sagara T, Sakoh H, Hashimoto M, Nakashima H, Kato T, Goto Y, Mizutani S, Azuma-Kanoh T, Tani T, Okuda S, Okamoto O, Ozaki S, Iwasawa Y, Ohta H, Kawamoto H.
    J Med Chem; 2009 Jul 23; 52(14):4091-4. PubMed ID: 19537798
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  • 7. Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline-4(3H),4'-piperidin]-3-ones as nociceptin receptor agonists.
    Mustazza C, Borioni A, Sestili I, Sbraccia M, Rodomonte A, Del Giudice MR.
    J Med Chem; 2008 Feb 28; 51(4):1058-62. PubMed ID: 18232652
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  • 11. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors.
    Zaveri NT, Journigan VB, Polgar WE.
    ACS Chem Neurosci; 2015 Apr 15; 6(4):646-57. PubMed ID: 25635572
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  • 12. High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
    Röver S, Adam G, Cesura AM, Galley G, Jenck F, Monsma FJ, Wichmann J, Dautzenberg FM.
    J Med Chem; 2000 Apr 06; 43(7):1329-38. PubMed ID: 10753470
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  • 13. In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist.
    Ozaki S, Kawamoto H, Itoh Y, Miyaji M, Azuma T, Ichikawa D, Nambu H, Iguchi T, Iwasawa Y, Ohta H.
    Eur J Pharmacol; 2000 Aug 18; 402(1-2):45-53. PubMed ID: 10940356
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  • 16. Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
    Ho GD, Bercovici A, Tulshian D, Greenlee WJ, Fawzi A, Fernandez X, McLeod RL, Smith Torhan A, Zhang H.
    Bioorg Med Chem Lett; 2007 Jun 01; 17(11):3028-33. PubMed ID: 17420123
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  • 18. Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.
    Halab L, Becker JA, Darula Z, Tourwé D, Kieffer BL, Simonin F, Lubell WD.
    J Med Chem; 2002 Nov 21; 45(24):5353-7. PubMed ID: 12431062
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