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Journal Abstract Search

138 related items for PubMed ID: 16455252

  • 21. Canonical 3'-deoxyribonucleotides as a chain terminator for HCV NS5B RNA-dependent RNA polymerase.
    Shim J, Larson G, Lai V, Naim S, Wu JZ.
    Antiviral Res; 2003 May; 58(3):243-51. PubMed ID: 12767472
    [Abstract] [Full Text] [Related]

  • 22. Hepatitis C virus (HCV) NS5B nonnucleoside inhibitors specifically block single-stranded viral RNA synthesis catalyzed by HCV replication complexes in vitro.
    Yang W, Sun Y, Phadke A, Deshpande M, Huang M.
    Antimicrob Agents Chemother; 2007 Jan; 51(1):338-42. PubMed ID: 17088480
    [Abstract] [Full Text] [Related]

  • 23. Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.
    Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carfì A.
    J Med Chem; 2009 Aug 27; 52(16):5217-27. PubMed ID: 19877603
    [Abstract] [Full Text] [Related]

  • 24. 2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp.
    Pacini B, Avolio S, Ercolani C, Koch U, Migliaccio G, Narjes F, Pacini L, Tomei L, Harper S.
    Bioorg Med Chem Lett; 2009 Nov 01; 19(21):6245-9. PubMed ID: 19800789
    [Abstract] [Full Text] [Related]

  • 25. Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization.
    Goulet S, Poupart MA, Gillard J, Poirier M, Kukolj G, Beaulieu PL.
    Bioorg Med Chem Lett; 2010 Jan 01; 20(1):196-200. PubMed ID: 19945870
    [Abstract] [Full Text] [Related]

  • 26. Identification and biological characterization of heterocyclic inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
    Dhanak D, Duffy KJ, Johnston VK, Lin-Goerke J, Darcy M, Shaw AN, Gu B, Silverman C, Gates AT, Nonnemacher MR, Earnshaw DL, Casper DJ, Kaura A, Baker A, Greenwood C, Gutshall LL, Maley D, DelVecchio A, Macarron R, Hofmann GA, Alnoah Z, Cheng HY, Chan G, Khandekar S, Keenan RM, Sarisky RT.
    J Biol Chem; 2002 Oct 11; 277(41):38322-7. PubMed ID: 12167642
    [Abstract] [Full Text] [Related]

  • 27. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
    Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA.
    Antimicrob Agents Chemother; 2010 Aug 11; 54(8):3187-96. PubMed ID: 20516278
    [Abstract] [Full Text] [Related]

  • 28. Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase.
    Lee JH, Lee S, Park MY, Myung H.
    Virol J; 2011 Jan 14; 8():18. PubMed ID: 21235805
    [Abstract] [Full Text] [Related]

  • 29. Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.
    Gopalsamy A, Lim K, Ellingboe JW, Krishnamurthy G, Orlowski M, Feld B, van Zeijl M, Howe AY.
    Bioorg Med Chem Lett; 2004 Aug 16; 14(16):4221-4. PubMed ID: 15261274
    [Abstract] [Full Text] [Related]

  • 30. Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors.
    Herlihy KJ, Graham JP, Kumpf R, Patick AK, Duggal R, Shi ST.
    Antimicrob Agents Chemother; 2008 Oct 16; 52(10):3523-31. PubMed ID: 18694956
    [Abstract] [Full Text] [Related]

  • 31. Discovery of HCV NS5B thumb site I inhibitors: core-refining from benzimidazole to indole scaffold.
    Zhao F, Liu N, Zhan P, Jiang X, Liu X.
    Eur J Med Chem; 2015 Apr 13; 94():218-28. PubMed ID: 25768704
    [Abstract] [Full Text] [Related]

  • 32. Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase.
    Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X, Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M, Mansour TS, O'Connell JF.
    Antimicrob Agents Chemother; 2004 Dec 13; 48(12):4813-21. PubMed ID: 15561861
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  • 33. Phosphoramidate dinucleosides as hepatitis C virus polymerase inhibitors.
    Zlatev I, Dutartre H, Barvik I, Neyts J, Canard B, Vasseur JJ, Alvarez K, Morvan F.
    J Med Chem; 2008 Sep 25; 51(18):5745-57. PubMed ID: 18800766
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  • 34. Novel 6-Aminoquinazolinone Derivatives as Potential Cross GT1-4 HCV NS5B Inhibitors.
    Nasr T, Aboshanab AM, Mpekoulis G, Drakopoulos A, Vassilaki N, Zoidis G, Abouzid KAM, Zaghary W.
    Viruses; 2022 Dec 12; 14(12):. PubMed ID: 36560772
    [Abstract] [Full Text] [Related]

  • 35. The juxtamembrane sequence of the Hepatitis C virus polymerase can affect RNA synthesis and inhibition by allosteric polymerase inhibitors.
    Wen Y, Lin X, Fan B, Ranjith-Kumar CT, Kao CC.
    Virus Genes; 2015 Aug 12; 51(1):1-11. PubMed ID: 25895103
    [Abstract] [Full Text] [Related]

  • 36. Multiple e-pharmacophore modeling, 3D-QSAR, and high-throughput virtual screening of hepatitis C virus NS5B polymerase inhibitors.
    Therese PJ, Manvar D, Kondepudi S, Battu MB, Sriram D, Basu A, Yogeeswari P, Kaushik-Basu N.
    J Chem Inf Model; 2014 Feb 24; 54(2):539-52. PubMed ID: 24460140
    [Abstract] [Full Text] [Related]

  • 37. Non-nucleoside inhibitors of NS5B polymerase binding to allosteric sites: 3D- QSAR and molecular docking studies.
    Cao H, Cao R, Zhang H, Zheng X, Gao D.
    Curr Med Chem; 2008 Feb 24; 15(15):1462-77. PubMed ID: 18537623
    [Abstract] [Full Text] [Related]

  • 38. 5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
    Ruebsam F, Tran CV, Li LS, Kim SH, Xiang AX, Zhou Y, Blazel JK, Sun Z, Dragovich PS, Zhao J, McGuire HM, Murphy DE, Tran MT, Stankovic N, Ellis DA, Gobbi A, Showalter RE, Webber SE, Shah AM, Tsan M, Patel RA, Lebrun LA, Hou HJ, Kamran R, Sergeeva MV, Bartkowski DM, Nolan TG, Norris DA, Kirkovsky L.
    Bioorg Med Chem Lett; 2009 Jan 15; 19(2):451-8. PubMed ID: 19054673
    [Abstract] [Full Text] [Related]

  • 39. A novel hepatitis C virus NS5B polymerase assay of de novo initiated RNA synthesis directed from a heteropolymeric RNA template.
    Ferrari E, Huang HC.
    Methods Mol Biol; 2013 Jan 15; 1030():81-92. PubMed ID: 23821261
    [Abstract] [Full Text] [Related]

  • 40. Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase.
    Harper S, Pacini B, Avolio S, Di Filippo M, Migliaccio G, Laufer R, De Francesco R, Rowley M, Narjes F.
    J Med Chem; 2005 Mar 10; 48(5):1314-7. PubMed ID: 15743173
    [Abstract] [Full Text] [Related]

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