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Journal Abstract Search

241 related items for PubMed ID: 16456093

  • 1. Peroxisome proliferator-activated receptor-alpha,gamma-agonist improves insulin sensitivity and prevents loss of left ventricular function in obese dyslipidemic mice.
    Verreth W, Ganame J, Mertens A, Bernar H, Herregods MC, Holvoet P.
    Arterioscler Thromb Vasc Biol; 2006 Apr; 26(4):922-8. PubMed ID: 16456093
    [Abstract] [Full Text] [Related]

  • 2. Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.
    Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki JK, Mertens A, Quarck R, Benhabilès N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, Holvoet P.
    Circulation; 2004 Nov 16; 110(20):3259-69. PubMed ID: 15533870
    [Abstract] [Full Text] [Related]

  • 3. PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.
    Kim MK, Chae YN, Son MH, Kim SH, Kim JK, Moon HS, Park CS, Bae MH, Kim E, Han T, Choi HH, Shin YA, Ahn BN, Lee CH, Lim JI, Shin CY.
    Eur J Pharmacol; 2008 Oct 24; 595(1-3):119-25. PubMed ID: 18727927
    [Abstract] [Full Text] [Related]

  • 4. Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes.
    Han KL, Choi JS, Lee JY, Song J, Joe MK, Jung MH, Hwang JK.
    Diabetes; 2008 Mar 24; 57(3):737-45. PubMed ID: 18065517
    [Abstract] [Full Text] [Related]

  • 5. Peroxisome proliferator activated receptor alpha/gamma dual agonist tesaglitazar attenuates diabetic nephropathy in db/db mice.
    Cha DR, Zhang X, Zhang Y, Wu J, Su D, Han JY, Fang X, Yu B, Breyer MD, Guan Y.
    Diabetes; 2007 Aug 24; 56(8):2036-45. PubMed ID: 17536062
    [Abstract] [Full Text] [Related]

  • 6. Effect of GCP-02, a PPARalpha/gamma dual activator, on glucose and lipid metabolism in insulin-resistant mice.
    Wang ZJ, Liu Q, Li PP, Zou CH, Shen ZF.
    Eur J Pharmacol; 2008 Feb 02; 580(1-2):277-83. PubMed ID: 18048028
    [Abstract] [Full Text] [Related]

  • 7. The dual peroxisome proliferator-activated receptor alpha/gamma agonist tesaglitazar further improves the lipid profile in dyslipidemic subjects treated with atorvastatin.
    Tonstad S, Retterstøl K, Ose L, Ohman KP, Lindberg MB, Svensson M.
    Metabolism; 2007 Sep 02; 56(9):1285-92. PubMed ID: 17697874
    [Abstract] [Full Text] [Related]

  • 8. Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.
    Harrity T, Farrelly D, Tieman A, Chu C, Kunselman L, Gu L, Ponticiello R, Cap M, Qu F, Shao C, Wang W, Zhang H, Fenderson W, Chen S, Devasthale P, Jeon Y, Seethala R, Yang WP, Ren J, Zhou M, Ryono D, Biller S, Mookhtiar KA, Wetterau J, Gregg R, Cheng PT, Hariharan N.
    Diabetes; 2006 Jan 02; 55(1):240-8. PubMed ID: 16380499
    [Abstract] [Full Text] [Related]

  • 9. C333H, a novel PPARalpha/gamma dual agonist, has beneficial effects on insulin resistance and lipid metabolism.
    Xu C, Wang LL, Liu HY, Zhou XB, Cao YL, Li S.
    Acta Pharmacol Sin; 2006 Feb 02; 27(2):223-8. PubMed ID: 16412273
    [Abstract] [Full Text] [Related]

  • 10. A nonthiazolidinedione peroxisome proliferator-activated receptor α/γ dual agonist CG301360 alleviates insulin resistance and lipid dysregulation in db/db mice.
    Jeong HW, Lee JW, Kim WS, Choe SS, Shin HJ, Lee GY, Shin D, Lee JH, Choi EB, Lee HK, Yon GH, Cho B, Kim HR, Choi SH, Chung YS, Park SB, Chung H, Ro S, Kim JB.
    Mol Pharmacol; 2010 Nov 02; 78(5):877-85. PubMed ID: 20724462
    [Abstract] [Full Text] [Related]

  • 11. Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.
    Devasthale PV, Chen S, Jeon Y, Qu F, Shao C, Wang W, Zhang H, Cap M, Farrelly D, Golla R, Grover G, Harrity T, Ma Z, Moore L, Ren J, Seethala R, Cheng L, Sleph P, Sun W, Tieman A, Wetterau JR, Doweyko A, Chandrasena G, Chang SY, Humphreys WG, Sasseville VG, Biller SA, Ryono DE, Selan F, Hariharan N, Cheng PT.
    J Med Chem; 2005 Mar 24; 48(6):2248-50. PubMed ID: 15771468
    [Abstract] [Full Text] [Related]

  • 12. A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent models of type 2 diabetes and dyslipidemia.
    Reifel-Miller A, Otto K, Hawkins E, Barr R, Bensch WR, Bull C, Dana S, Klausing K, Martin JA, Rafaeloff-Phail R, Rafizadeh-Montrose C, Rhodes G, Robey R, Rojo I, Rungta D, Snyder D, Wilbur K, Zhang T, Zink R, Warshawsky A, Brozinick JT.
    Mol Endocrinol; 2005 Jun 24; 19(6):1593-605. PubMed ID: 15831517
    [Abstract] [Full Text] [Related]

  • 13. The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs.
    Gayet C, Leray V, Saito M, Siliart B, Nguyen P.
    Br J Nutr; 2007 Sep 24; 98(3):497-503. PubMed ID: 17475082
    [Abstract] [Full Text] [Related]

  • 14. The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice.
    Cong WN, Tao RY, Tian JY, Liu GT, Ye F.
    Life Sci; 2008 May 07; 82(19-20):983-90. PubMed ID: 18417155
    [Abstract] [Full Text] [Related]

  • 15. PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia.
    Hennuyer N, Tailleux A, Torpier G, Mezdour H, Fruchart JC, Staels B, Fiévet C.
    Arterioscler Thromb Vasc Biol; 2005 Sep 07; 25(9):1897-902. PubMed ID: 15994444
    [Abstract] [Full Text] [Related]

  • 16. A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects.
    Chang CH, McNamara LA, Wu MS, Muise ES, Tan Y, Wood HB, Meinke PT, Thompson JR, Doebber TW, Berger JP, McCann ME.
    Eur J Pharmacol; 2008 Apr 14; 584(1):192-201. PubMed ID: 18346728
    [Abstract] [Full Text] [Related]

  • 17. A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys.
    Wagner JD, Shadoan MK, Zhang L, Ward GM, Royer LJ, Kavanagh K, Francone OL, Auerbach BJ, Harwood HJ.
    J Pharmacol Exp Ther; 2010 Jun 14; 333(3):844-53. PubMed ID: 20190014
    [Abstract] [Full Text] [Related]

  • 18. Mechanism by which a novel non-thiazolidinedione peroxisome proliferator-activated receptor gamma agonist, FK614, ameliorates insulin resistance in Zucker fatty rats.
    Minoura H, Takeshita S, Kimura C, Hirosumi J, Takakura S, Kawamura I, Seki J, Manda T, Mutoh S.
    Diabetes Obes Metab; 2007 May 14; 9(3):369-78. PubMed ID: 17391165
    [Abstract] [Full Text] [Related]

  • 19. Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice.
    Hu X, Feng Y, Shen Y, Zhao XF, Yu JH, Yang YS, Leng Y.
    Acta Pharmacol Sin; 2006 Oct 14; 27(10):1346-52. PubMed ID: 17007742
    [Abstract] [Full Text] [Related]

  • 20. Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice.
    Zadelaar AS, Boesten LS, Jukema JW, van Vlijmen BJ, Kooistra T, Emeis JJ, Lundholm E, Camejo G, Havekes LM.
    Arterioscler Thromb Vasc Biol; 2006 Nov 14; 26(11):2560-6. PubMed ID: 16931788
    [Abstract] [Full Text] [Related]

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