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Journal Abstract Search

321 related items for PubMed ID: 16458503

  • 1. Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1.
    Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Sim T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Ohmori O, Caldwell J, Gray N, He Y.
    Bioorg Med Chem Lett; 2006 Apr 15; 16(8):2173-6. PubMed ID: 16458503
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  • 3. The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: a new class of Aurora-A kinase inhibitors.
    Moriarty KJ, Koblish HK, Garrabrant T, Maisuria J, Khalil E, Ali F, Petrounia IP, Crysler CS, Maroney AC, Johnson DL, Galemmo RA.
    Bioorg Med Chem Lett; 2006 Nov 15; 16(22):5778-83. PubMed ID: 16949284
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  • 6. Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.
    Kaspersen SJ, Sørum C, Willassen V, Fuglseth E, Kjøbli E, Bjørkøy G, Sundby E, Hoff BH.
    Eur J Med Chem; 2011 Dec 15; 46(12):6002-14. PubMed ID: 22018877
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  • 7. Benzoyl ring halogenated classical 2-amino-6-methyl-3,4-dihydro-4-oxo-5-substituted thiobenzoyl-7H-pyrrolo[2,3-d]pyrimidine antifolates as inhibitors of thymidylate synthase and as antitumor agents.
    Gangjee A, Jain HD, McGuire JJ, Kisliuk RL.
    J Med Chem; 2004 Dec 30; 47(27):6730-9. PubMed ID: 15615522
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  • 8. Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents.
    Wang R, Chen Y, Zhao X, Yu S, Yang B, Wu T, Guo J, Hao C, Zhao D, Cheng M.
    Eur J Med Chem; 2019 Dec 01; 183():111716. PubMed ID: 31550660
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  • 9. Synthesis of novel pyrrole and pyrrolo[2,3-d]pyrimidine derivatives bearing sulfonamide moiety for evaluation as anticancer and radiosensitizing agents.
    Ghorab MM, Ragab FA, Heiba HI, Youssef HA, El-Gazzar MG.
    Bioorg Med Chem Lett; 2010 Nov 01; 20(21):6316-20. PubMed ID: 20850308
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  • 10. A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.
    Shi Q, Hjelmeland AB, Keir ST, Song L, Wickman S, Jackson D, Ohmori O, Bigner DD, Friedman HS, Rich JN.
    Mol Carcinog; 2007 Jun 01; 46(6):488-96. PubMed ID: 17219439
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  • 12. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
    Gangjee A, Lin X, Kisliuk RL, McGuire JJ.
    J Med Chem; 2005 Nov 17; 48(23):7215-22. PubMed ID: 16279780
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  • 13. Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study.
    Wang R, Zhao X, Yu S, Chen Y, Cui H, Wu T, Hao C, Zhao D, Cheng M.
    Bioorg Chem; 2020 Sep 17; 102():104092. PubMed ID: 32707280
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  • 14. Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents.
    Tan H, Liu Y, Gong C, Zhang J, Huang J, Zhang Q.
    Eur J Med Chem; 2021 Nov 05; 223():113670. PubMed ID: 34214842
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  • 15. Synthesis of certain pyrrole derivatives as antimicrobial agents.
    Mohamed MS, El-Domany RA, Abd El-Hameed RH.
    Acta Pharm; 2009 Jun 05; 59(2):145-58. PubMed ID: 19564140
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  • 16. Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.
    Menichincheri M, Albanese C, Alli C, Ballinari D, Bargiotti A, Caldarelli M, Ciavolella A, Cirla A, Colombo M, Colotta F, Croci V, D'Alessio R, D'Anello M, Ermoli A, Fiorentini F, Forte B, Galvani A, Giordano P, Isacchi A, Martina K, Molinari A, Moll JK, Montagnoli A, Orsini P, Orzi F, Pesenti E, Pillan A, Roletto F, Scolaro A, Tatò M, Tibolla M, Valsasina B, Varasi M, Vianello P, Volpi D, Santocanale C, Vanotti E.
    J Med Chem; 2010 Oct 28; 53(20):7296-315. PubMed ID: 20873740
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  • 20. Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.
    Hayakawa M, Kaizawa H, Moritomo H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Workman P, Waterfield MD, Parker P.
    Bioorg Med Chem Lett; 2007 May 01; 17(9):2438-42. PubMed ID: 17339109
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