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326 related items for PubMed ID: 16464945

  • 1. A novel selective progesterone receptor modulator asoprisnil (J867) inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.
    Chen W, Ohara N, Wang J, Xu Q, Liu J, Morikawa A, Sasaki H, Yoshida S, Demanno DA, Chwalisz K, Maruo T.
    J Clin Endocrinol Metab; 2006 Apr; 91(4):1296-304. PubMed ID: 16464945
    [Abstract] [Full Text] [Related]

  • 2. Comparative effects of SPRM asoprisnil (J867) on proliferation, apoptosis, and the expression of growth factors in cultured uterine leiomyoma cells and normal myometrial cells.
    Ohara N, Morikawa A, Chen W, Wang J, DeManno DA, Chwalisz K, Maruo T.
    Reprod Sci; 2007 Dec; 14(8 Suppl):20-7. PubMed ID: 18089606
    [Abstract] [Full Text] [Related]

  • 3. Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells.
    Xu Q, Takekida S, Ohara N, Chen W, Sitruk-Ware R, Johansson ED, Maruo T.
    J Clin Endocrinol Metab; 2005 Feb; 90(2):953-61. PubMed ID: 15572421
    [Abstract] [Full Text] [Related]

  • 4. A novel selective progesterone receptor modulator asoprisnil activates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated signaling pathway in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells.
    Sasaki H, Ohara N, Xu Q, Wang J, DeManno DA, Chwalisz K, Yoshida S, Maruo T.
    J Clin Endocrinol Metab; 2007 Feb; 92(2):616-23. PubMed ID: 17105846
    [Abstract] [Full Text] [Related]

  • 5. Selective progesterone receptor modulator asoprisnil induces endoplasmic reticulum stress in cultured human uterine leiomyoma cells.
    Xu Q, Ohara N, Liu J, Nakabayashi K, DeManno D, Chwalisz K, Yoshida S, Maruo T.
    Am J Physiol Endocrinol Metab; 2007 Oct; 293(4):E1002-11. PubMed ID: 17652152
    [Abstract] [Full Text] [Related]

  • 6. A novel selective progesterone receptor modulator asoprisnil (J867) down-regulates the expression of EGF, IGF-I, TGFbeta3 and their receptors in cultured uterine leiomyoma cells.
    Wang J, Ohara N, Wang Z, Chen W, Morikawa A, Sasaki H, DeManno DA, Chwalisz K, Maruo T.
    Hum Reprod; 2006 Jul; 21(7):1869-77. PubMed ID: 16613890
    [Abstract] [Full Text] [Related]

  • 7. Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth.
    Yoshida S, Ohara N, Xu Q, Chen W, Wang J, Nakabayashi K, Sasaki H, Morikawa A, Maruo T.
    Semin Reprod Med; 2010 May; 28(3):260-73. PubMed ID: 20414849
    [Abstract] [Full Text] [Related]

  • 8. Recombinant H2 relaxin inhibits apoptosis and induces cell proliferation in cultured leiomyoma cells without affecting those in cultured normal myometrial cells.
    Suzuki K, Nakabayashi K, Yamada AY, Lodhi RS, Hazama R, Ebina Y, Yamada H.
    Fertil Steril; 2012 Mar; 97(3):734-41. PubMed ID: 22226177
    [Abstract] [Full Text] [Related]

  • 9. Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer.
    Morikawa A, Ohara N, Xu Q, Nakabayashi K, DeManno DA, Chwalisz K, Yoshida S, Maruo T.
    Hum Reprod; 2008 Apr; 23(4):944-51. PubMed ID: 18281245
    [Abstract] [Full Text] [Related]

  • 10. Comparative effects of heparin-binding epidermal growth factor-like growth factor on the growth of cultured human uterine leiomyoma cells and myometrial cells.
    Wang J, Ohara N, Takekida S, Xu Q, Maruo T.
    Hum Reprod; 2005 Jun; 20(6):1456-65. PubMed ID: 15760954
    [Abstract] [Full Text] [Related]

  • 11. Concentration-dependent effects of a selective estrogen receptor modulator raloxifene on proliferation and apoptosis in human uterine leiomyoma cells cultured in vitro.
    Liu J, Matsuo H, Xu Q, Chen W, Wang J, Maruo T.
    Hum Reprod; 2007 May; 22(5):1253-9. PubMed ID: 17220163
    [Abstract] [Full Text] [Related]

  • 12. Gonadotropin-releasing hormone antagonist cetrorelix down-regulates proliferating cell nuclear antigen and epidermal growth factor expression and up-regulates apoptosis in association with enhanced poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human leiomyoma cells.
    Chen W, Yoshida S, Ohara N, Matsuo H, Morizane M, Maruo T.
    J Clin Endocrinol Metab; 2005 Feb; 90(2):884-92. PubMed ID: 15536154
    [Abstract] [Full Text] [Related]

  • 13. The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata.
    Williams AR, Critchley HO, Osei J, Ingamells S, Cameron IT, Han C, Chwalisz K.
    Hum Reprod; 2007 Jun; 22(6):1696-704. PubMed ID: 17339234
    [Abstract] [Full Text] [Related]

  • 14. The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells.
    Luo X, Yin P, Coon V JS, Cheng YH, Wiehle RD, Bulun SE.
    Fertil Steril; 2010 May 15; 93(8):2668-73. PubMed ID: 20056218
    [Abstract] [Full Text] [Related]

  • 15. Up-regulation by IGF-I of proliferating cell nuclear antigen and Bcl-2 protein expression in human uterine leiomyoma cells.
    Gao Z, Matsuo H, Wang Y, Nakago S, Maruo T.
    J Clin Endocrinol Metab; 2001 Nov 15; 86(11):5593-9. PubMed ID: 11701740
    [Abstract] [Full Text] [Related]

  • 16. Changes in proliferating and apoptotic markers of leiomyoma following treatment with a selective progesterone receptor modulator or gonadotropin-releasing hormone agonist.
    Yun BS, Seong SJ, Cha DH, Kim JY, Kim ML, Shim JY, Park JE.
    Eur J Obstet Gynecol Reprod Biol; 2015 Aug 15; 191():62-7. PubMed ID: 26093349
    [Abstract] [Full Text] [Related]

  • 17. Effect of asoprisnil on uterine proliferation markers and endometrial expression of the tumour suppressor gene, PTEN.
    Wilkens J, Williams AR, Chwalisz K, Han C, Cameron IT, Critchley HO.
    Hum Reprod; 2009 May 15; 24(5):1036-44. PubMed ID: 19176543
    [Abstract] [Full Text] [Related]

  • 18. Effects of the selective progesterone receptor modulator asoprisnil on uterine artery blood flow, ovarian activity, and clinical symptoms in patients with uterine leiomyomata scheduled for hysterectomy.
    Wilkens J, Chwalisz K, Han C, Walker J, Cameron IT, Ingamells S, Lawrence AC, Lumsden MA, Hapangama D, Williams AR, Critchley HO.
    J Clin Endocrinol Metab; 2008 Dec 15; 93(12):4664-71. PubMed ID: 18765509
    [Abstract] [Full Text] [Related]

  • 19. A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator.
    Madauss KP, Grygielko ET, Deng SJ, Sulpizio AC, Stanley TB, Wu C, Short SA, Thompson SK, Stewart EL, Laping NJ, Williams SP, Bray JD.
    Mol Endocrinol; 2007 May 15; 21(5):1066-81. PubMed ID: 17356170
    [Abstract] [Full Text] [Related]

  • 20. Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma.
    Shimomura Y, Matsuo H, Samoto T, Maruo T.
    J Clin Endocrinol Metab; 1998 Jun 15; 83(6):2192-8. PubMed ID: 9626159
    [Abstract] [Full Text] [Related]

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