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Journal Abstract Search

162 related items for PubMed ID: 16480258

  • 1. 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
    Semple G, Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Tamura SY, Chen R, Richman JG, Connolly DT.
    J Med Chem; 2006 Feb 23; 49(4):1227-30. PubMed ID: 16480258
    [Abstract] [Full Text] [Related]

  • 2. 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
    Skinner PJ, Webb PJ, Sage CR, Dang TH, Pride CC, Chen R, Tamura SY, Richman JG, Connolly DT, Semple G.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4207-9. PubMed ID: 19524438
    [Abstract] [Full Text] [Related]

  • 3. Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a.
    Skinner PJ, Cherrier MC, Webb PJ, Shin YJ, Gharbaoui T, Lindstrom A, Hong V, Tamura SY, Dang HT, Pride CC, Chen R, Richman JG, Connolly DT, Semple G.
    Bioorg Med Chem Lett; 2007 Oct 15; 17(20):5620-3. PubMed ID: 17804224
    [Abstract] [Full Text] [Related]

  • 4. 3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b.
    Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Dang HT, Pride CC, Chen R, Tamura SY, Richman JG, Connolly DT, Semple G.
    Bioorg Med Chem Lett; 2007 Dec 01; 17(23):6619-22. PubMed ID: 17931863
    [Abstract] [Full Text] [Related]

  • 5. Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.
    Jung JK, Johnson BR, Duong T, Decaire M, Uy J, Gharbaoui T, Boatman PD, Sage CR, Chen R, Richman JG, Connolly DT, Semple G.
    J Med Chem; 2007 Apr 05; 50(7):1445-8. PubMed ID: 17358052
    [Abstract] [Full Text] [Related]

  • 6. Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74.
    Mahboubi K, Witman-Jones T, Adamus JE, Letsinger JT, Whitehouse D, Moorman AR, Sawicki D, Bergenhem N, Ross SA.
    Biochem Biophys Res Commun; 2006 Feb 10; 340(2):482-90. PubMed ID: 16389067
    [Abstract] [Full Text] [Related]

  • 7. Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
    Shen HC, Ding FX, Deng Q, Wilsie LC, Krsmanovic ML, Taggart AK, Carballo-Jane E, Ren N, Cai TQ, Wu TJ, Wu KK, Cheng K, Chen Q, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL.
    J Med Chem; 2009 Apr 23; 52(8):2587-602. PubMed ID: 19309152
    [Abstract] [Full Text] [Related]

  • 8. Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.
    Peters JU, Kühne H, Dehmlow H, Grether U, Conte A, Hainzl D, Hertel C, Kratochwil NA, Otteneder M, Narquizian R, Panousis CG, Ricklin F, Röver S.
    Bioorg Med Chem Lett; 2010 Sep 15; 20(18):5426-30. PubMed ID: 20724150
    [Abstract] [Full Text] [Related]

  • 9. Nicotinic acid receptor subtypes and their ligands.
    Soudijn W, van Wijngaarden I, Ijzerman AP.
    Med Res Rev; 2007 May 15; 27(3):417-33. PubMed ID: 17238156
    [Abstract] [Full Text] [Related]

  • 10. GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.
    Imbriglio JE, Chang S, Liang R, Raghavan S, Schmidt D, Smenton A, Tria S, Schrader TO, Jung JK, Esser C, Holt TG, Wolff MS, Taggart AK, Cheng K, Carballo-Jane E, Waters MG, Tata JR, Colletti SL.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4472-4. PubMed ID: 20615702
    [Abstract] [Full Text] [Related]

  • 11. Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.
    Zhang Y, Schmidt RJ, Foxworthy P, Emkey R, Oler JK, Large TH, Wang H, Su EW, Mosior MK, Eacho PI, Cao G.
    Biochem Biophys Res Commun; 2005 Aug 26; 334(2):729-32. PubMed ID: 16018973
    [Abstract] [Full Text] [Related]

  • 12. Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.
    Zellner C, Pullinger CR, Aouizerat BE, Frost PH, Kwok PY, Malloy MJ, Kane JP.
    Hum Mutat; 2005 Jan 26; 25(1):18-21. PubMed ID: 15580557
    [Abstract] [Full Text] [Related]

  • 13. Niacin stimulates adiponectin secretion through the GPR109A receptor.
    Plaisance EP, Lukasova M, Offermanns S, Zhang Y, Cao G, Judd RL.
    Am J Physiol Endocrinol Metab; 2009 Mar 26; 296(3):E549-58. PubMed ID: 19141678
    [Abstract] [Full Text] [Related]

  • 14. Nicotinic acid (niacin) receptor agonists: will they be useful therapeutic agents?
    Kamanna VS, Kashyap ML.
    Am J Cardiol; 2007 Dec 03; 100(11 A):S53-61. PubMed ID: 18047854
    [Abstract] [Full Text] [Related]

  • 15. The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist.
    Tang H, Lu JY, Zheng X, Yang Y, Reagan JD.
    Biochem Biophys Res Commun; 2008 Oct 31; 375(4):562-5. PubMed ID: 18722346
    [Abstract] [Full Text] [Related]

  • 16. Characterization of determinants of ligand binding to the nicotinic acid receptor GPR109A (HM74A/PUMA-G).
    Tunaru S, Lättig J, Kero J, Krause G, Offermanns S.
    Mol Pharmacol; 2005 Nov 31; 68(5):1271-80. PubMed ID: 16099840
    [Abstract] [Full Text] [Related]

  • 17. GPR109a agonists. Part 1: 5-Alkyl and 5-aryl-pyrazole-tetrazoles as agonists of the human orphan G-protein coupled receptor GPR109a.
    Imbriglio JE, Chang S, Liang R, Raghavan S, Schmidt D, Smenton A, Tria S, Schrader TO, Jung JK, Esser C, Taggart AK, Cheng K, Carballo-Jane E, Gerard Waters M, Tata JR, Colletti SL.
    Bioorg Med Chem Lett; 2009 Apr 15; 19(8):2121-4. PubMed ID: 19307116
    [Abstract] [Full Text] [Related]

  • 18. 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.
    Semple G, Skinner PJ, Gharbaoui T, Shin YJ, Jung JK, Cherrier MC, Webb PJ, Tamura SY, Boatman PD, Sage CR, Schrader TO, Chen R, Colletti SL, Tata JR, Waters MG, Cheng K, Taggart AK, Cai TQ, Carballo-Jane E, Behan DP, Connolly DT, Richman JG.
    J Med Chem; 2008 Aug 28; 51(16):5101-8. PubMed ID: 18665582
    [Abstract] [Full Text] [Related]

  • 19. Identification of a nicotinic acid receptor: is this the molecular target for the oldest lipid-lowering drug?
    Pike NB, Wise A.
    Curr Opin Investig Drugs; 2004 Mar 28; 5(3):271-5. PubMed ID: 15083592
    [Abstract] [Full Text] [Related]

  • 20. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.
    Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S.
    Nat Med; 2003 Mar 28; 9(3):352-5. PubMed ID: 12563315
    [Abstract] [Full Text] [Related]

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