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334 related items for PubMed ID: 16482518

  • 1. Tissue distribution of N-acetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster.
    Hein DW, Doll MA, Nerland DE, Fretland AJ.
    Mol Carcinog; 2006 Apr; 45(4):230-8. PubMed ID: 16482518
    [Abstract] [Full Text] [Related]

  • 2. Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.
    Hein DW, Doll MA, Gray K, Rustan TD, Ferguson RJ.
    Cancer Res; 1993 Feb 01; 53(3):509-14. PubMed ID: 8425184
    [Abstract] [Full Text] [Related]

  • 3. 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator rats.
    Jefferson FA, Xiao GH, Hein DW.
    Toxicol Sci; 2009 Jan 01; 107(1):293-7. PubMed ID: 18842621
    [Abstract] [Full Text] [Related]

  • 4. Construction of Syrian hamster lines congenic at the polymorphic acetyltransferase locus (NAT2): acetylator genotype-dependent N- and O-acetylation of arylamine carcinogens.
    Hein DW, Doll MA, Rustan TD, Gray K, Ferguson RJ, Feng Y.
    Toxicol Appl Pharmacol; 1994 Jan 01; 124(1):16-24. PubMed ID: 8291057
    [Abstract] [Full Text] [Related]

  • 5. Prostate expression of N-acetyltransferase 1 (NAT1) and 2 (NAT2) in rapid and slow acetylator congenic Syrian hamster.
    Hein DW, Doll MA, Xiao GH, Feng Y.
    Pharmacogenetics; 2003 Mar 01; 13(3):159-67. PubMed ID: 12618593
    [Abstract] [Full Text] [Related]

  • 6. Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens.
    Fretland AJ, Doll MA, Gray K, Feng Y, Hein DW.
    Toxicol Appl Pharmacol; 1997 Feb 01; 142(2):360-6. PubMed ID: 9070359
    [Abstract] [Full Text] [Related]

  • 7. Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
    Fretland AJ, Devanaboyina US, Doll MA, Zhao S, Xiao GH, Hein DW.
    Toxicol Sci; 2003 Aug 01; 74(2):253-9. PubMed ID: 12773763
    [Abstract] [Full Text] [Related]

  • 8. Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: relationship to arylamine N-acetyltransferase.
    Hein DW, Flammang TJ, Kirlin WG, Trinidad A, Ogolla F.
    Carcinogenesis; 1987 Dec 01; 8(12):1767-74. PubMed ID: 3677303
    [Abstract] [Full Text] [Related]

  • 9. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes.
    Habil MR, Doll MA, Hein DW.
    Pharmacogenet Genomics; 2020 Apr 01; 30(3):61-65. PubMed ID: 31895247
    [Abstract] [Full Text] [Related]

  • 10. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.
    Hein DW, Doll MA, Rustan TD, Gray K, Feng Y, Ferguson RJ, Grant DM.
    Carcinogenesis; 1993 Aug 01; 14(8):1633-8. PubMed ID: 8353847
    [Abstract] [Full Text] [Related]

  • 11. Cloning, expression, and functional characterization of rapid and slow acetylator polymorphic N-acetyl-transferase encoding genes of the Syrian hamster.
    Ferguson RJ, Doll MA, Rustan TD, Hein DW.
    Pharmacogenetics; 1996 Feb 01; 6(1):55-66. PubMed ID: 8845861
    [Abstract] [Full Text] [Related]

  • 12. Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype.
    Hein DW, Doll MA.
    Arch Toxicol; 2017 Aug 01; 91(8):2827-2835. PubMed ID: 28523442
    [Abstract] [Full Text] [Related]

  • 13. Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.
    Hein DW, Bendaly J, Neale JR, Doll MA.
    Drug Metab Dispos; 2008 Dec 01; 36(12):2452-9. PubMed ID: 18799801
    [Abstract] [Full Text] [Related]

  • 14. Codominant expression of N-acetylation and O-acetylation activities catalyzed by N-acetyltransferase 2 in human hepatocytes.
    Doll MA, Zang Y, Moeller T, Hein DW.
    J Pharmacol Exp Ther; 2010 Aug 01; 334(2):540-4. PubMed ID: 20430842
    [Abstract] [Full Text] [Related]

  • 15. N-acetyltransferase 2 phenotype but not NAT1*10 genotype affects aminobiphenyl-hemoglobin adduct levels.
    Probst-Hensch NM, Bell DA, Watson MA, Skipper PL, Tannenbaum SR, Chan KK, Ross RK, Yu MC.
    Cancer Epidemiol Biomarkers Prev; 2000 Jun 01; 9(6):619-23. PubMed ID: 10868698
    [Abstract] [Full Text] [Related]

  • 16. Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse.
    Hein DW, Trinidad A, Yerokun T, Ferguson RJ, Kirlin WG, Weber WW.
    Drug Metab Dispos; 1988 Jun 01; 16(3):341-7. PubMed ID: 2900723
    [Abstract] [Full Text] [Related]

  • 17. Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.
    Yerokun T, Kirlin WG, Trinidad A, Ferguson RJ, Ogolla F, Andrews AF, Brady PK, Hein DW.
    Drug Metab Dispos; 1989 Jun 01; 17(3):231-7. PubMed ID: 2568902
    [Abstract] [Full Text] [Related]

  • 18. Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase.
    Trinidad A, Hein DW, Rustan TD, Ferguson RJ, Miller LS, Bucher KD, Kirlin WG, Ogolla F, Andrews AF.
    Cancer Res; 1990 Dec 15; 50(24):7942-9. PubMed ID: 2253236
    [Abstract] [Full Text] [Related]

  • 19. Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of Syrian hamsters congenic at the polymorphic acetyltransferase locus.
    Hein DW, Rustan TD, Bucher KD, Miller LS.
    J Pharmacol Exp Ther; 1991 Nov 15; 259(2):699-704. PubMed ID: 1941618
    [Abstract] [Full Text] [Related]

  • 20. Acetylation of putative arylamine and alkylaniline carcinogens in immortalized human fibroblasts transfected with rapid and slow acetylator N-acetyltransferase 2 haplotypes.
    Leggett CS, Doll MA, States JC, Hein DW.
    Arch Toxicol; 2021 Jan 15; 95(1):311-319. PubMed ID: 33136180
    [Abstract] [Full Text] [Related]

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