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PUBMED FOR HANDHELDS

Journal Abstract Search

239 related items for PubMed ID: 16485904

  • 1. Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
    Kent UM, Lin HL, Mills DE, Regal KA, Hollenberg PF.
    Chem Res Toxicol; 2006 Feb; 19(2):279-87. PubMed ID: 16485904
    [Abstract] [Full Text] [Related]

  • 2. Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites.
    Kent UM, Mills DE, Rajnarayanan RV, Alworth WL, Hollenberg PF.
    J Pharmacol Exp Ther; 2002 Feb; 300(2):549-58. PubMed ID: 11805216
    [Abstract] [Full Text] [Related]

  • 3. Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6.
    Kent UM, Sridar C, Spahlinger G, Hollenberg PF.
    Chem Res Toxicol; 2008 Oct; 21(10):1956-63. PubMed ID: 18729327
    [Abstract] [Full Text] [Related]

  • 4. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane.
    Chun J, Kent UM, Moss RM, Sayre LM, Hollenberg PF.
    Drug Metab Dispos; 2000 Aug; 28(8):905-11. PubMed ID: 10901699
    [Abstract] [Full Text] [Related]

  • 5. The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis.
    Lin HL, Kent UM, Zhang H, Waskell L, Hollenberg PF.
    J Pharmacol Exp Ther; 2004 Dec; 311(3):855-63. PubMed ID: 15302894
    [Abstract] [Full Text] [Related]

  • 6. Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites.
    Von Weymarn LB, Sridar C, Hollenberg PF.
    J Pharmacol Exp Ther; 2004 Oct; 311(1):71-9. PubMed ID: 15178696
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  • 10. Selective pathways for the metabolism of phencyclidine by cytochrome p450 2b enzymes: identification of electrophilic metabolites, glutathione, and N-acetyl cysteine adducts.
    Shebley M, Jushchyshyn MI, Hollenberg PF.
    Drug Metab Dispos; 2006 Mar; 34(3):375-83. PubMed ID: 16326815
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  • 11. Mechanism-based inactivation of cytochrome P450 2B1 by 8-methoxypsoralen and several other furanocoumarins.
    Koenigs LL, Trager WF.
    Biochemistry; 1998 Sep 22; 37(38):13184-93. PubMed ID: 9748325
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  • 12. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5.
    Lin HL, Kent UM, Hollenberg PF.
    J Pharmacol Exp Ther; 2005 Apr 22; 313(1):154-64. PubMed ID: 15608076
    [Abstract] [Full Text] [Related]

  • 13. Mechanism of inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI, Wahlstrom JL, Hollenberg PF, Wienkers LC.
    Drug Metab Dispos; 2006 Sep 22; 34(9):1523-9. PubMed ID: 16782764
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  • 14. Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital.
    He K, Falick AM, Chen B, Nilsson F, Correia MA.
    Chem Res Toxicol; 1996 Sep 22; 9(3):614-22. PubMed ID: 8728507
    [Abstract] [Full Text] [Related]

  • 15. Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein.
    Lin HL, Kent UM, Hollenberg PF.
    J Pharmacol Exp Ther; 2002 Apr 22; 301(1):160-7. PubMed ID: 11907170
    [Abstract] [Full Text] [Related]

  • 16. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP, Kornecki K, Wolkowski JP, Chupak L, Kalgutkar AS, O'Donnell JP.
    Chem Res Toxicol; 2007 Oct 22; 20(10):1488-97. PubMed ID: 17892269
    [Abstract] [Full Text] [Related]

  • 17. Selective mechanism-based inactivation of cytochromes P-450 2B1 and P-450 2B6 by a series of xanthates.
    Yanev S, Kent UM, Pandova B, Hollenberg PF.
    Drug Metab Dispos; 1999 May 22; 27(5):600-4. PubMed ID: 10220489
    [Abstract] [Full Text] [Related]

  • 18. Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by n-propylxanthate.
    Kent UM, Yanev S, Hollenberg PF.
    Chem Res Toxicol; 1999 Apr 22; 12(4):317-22. PubMed ID: 10207119
    [Abstract] [Full Text] [Related]

  • 19. Mechanistic studies of cytochrome P450 2B1 inactivation by xanthates.
    Yanev SG, Kent UM, Roberts ES, Ballou DP, Hollenberg PF.
    Arch Biochem Biophys; 2000 Jun 01; 378(1):157-66. PubMed ID: 10871056
    [Abstract] [Full Text] [Related]

  • 20. Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry.
    Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF.
    Chem Res Toxicol; 2000 Apr 01; 13(4):262-70. PubMed ID: 10775326
    [Abstract] [Full Text] [Related]

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