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990 related items for PubMed ID: 16489060

  • 1. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.
    Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM.
    Clin Cancer Res; 2006 Feb 15; 12(4):1080-7. PubMed ID: 16489060
    [Abstract] [Full Text] [Related]

  • 2. Dysregulation of hypoxia inducible factor-1alpha in head and neck squamous cell carcinoma cell lines correlates with invasive potential.
    Cohen NA, Lai SY, Ziober AF, Ziober BL.
    Laryngoscope; 2004 Mar 15; 114(3):418-23. PubMed ID: 15091212
    [Abstract] [Full Text] [Related]

  • 3. Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth.
    Jokilehto T, Högel H, Heikkinen P, Rantanen K, Elenius K, Sundström J, Jaakkola PM.
    Exp Cell Res; 2010 Apr 15; 316(7):1169-78. PubMed ID: 20156434
    [Abstract] [Full Text] [Related]

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  • 5. Increase in gene dosage is a mechanism of HIF-1alpha constitutive expression in head and neck squamous cell carcinomas.
    Secades P, Rodrigo JP, Hermsen M, Alvarez C, Suarez C, Chiara MD.
    Genes Chromosomes Cancer; 2009 May 15; 48(5):441-54. PubMed ID: 19235921
    [Abstract] [Full Text] [Related]

  • 6. Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.
    Gross J, Fuchs J, Machulik A, Jahnke V, Kietzmann T, Bockmühl U.
    Int J Oncol; 2005 Sep 15; 27(3):807-14. PubMed ID: 16077932
    [Abstract] [Full Text] [Related]

  • 7. Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.
    Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R.
    J Cell Sci; 2012 Nov 01; 125(Pt 21):5168-76. PubMed ID: 22946054
    [Abstract] [Full Text] [Related]

  • 8. Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck.
    Luukkaa M, Jokilehto T, Kronqvist P, Vahlberg T, Grénman R, Jaakkola P, Minn H.
    Int J Radiat Biol; 2009 Nov 01; 85(10):900-8. PubMed ID: 19639506
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger.
    Choi KO, Lee T, Lee N, Kim JH, Yang EG, Yoon JM, Kim JH, Lee TG, Park H.
    Mol Pharmacol; 2005 Dec 01; 68(6):1803-9. PubMed ID: 16155211
    [Abstract] [Full Text] [Related]

  • 10. [Reciprocal regulation between hypoxia-inducible factor-1alpha and its prolyl hydroxylases in hypoxic pulmonary hypertension rats].
    Chen YR, Dai AG, Hu RC.
    Zhonghua Jie He He Hu Xi Za Zhi; 2006 Oct 01; 29(10):668-73. PubMed ID: 17129494
    [Abstract] [Full Text] [Related]

  • 11. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
    Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL.
    Cancer Res; 2002 May 01; 62(9):2493-7. PubMed ID: 11980639
    [Abstract] [Full Text] [Related]

  • 12. 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.
    Ricker JL, Chen Z, Yang XP, Pribluda VS, Swartz GM, Van Waes C.
    Clin Cancer Res; 2004 Dec 15; 10(24):8665-73. PubMed ID: 15623651
    [Abstract] [Full Text] [Related]

  • 13. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.
    Bobarykina AY, Minchenko DO, Opentanova IL, Moenner M, Caro J, Esumi H, Minchenko OH.
    Acta Biochim Pol; 2006 Dec 15; 53(4):789-99. PubMed ID: 17143338
    [Abstract] [Full Text] [Related]

  • 14. Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury.
    Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA.
    Circ Res; 2006 Jan 06; 98(1):133-40. PubMed ID: 16306444
    [Abstract] [Full Text] [Related]

  • 15. An activator of PHD2, KRH102140, decreases angiogenesis via inhibition of HIF-1α.
    Nepal M, Gong YD, Park YR, Soh Y.
    Cell Biochem Funct; 2011 Mar 06; 29(2):126-34. PubMed ID: 21287578
    [Abstract] [Full Text] [Related]

  • 16. Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.
    Peurala E, Koivunen P, Bloigu R, Haapasaari KM, Jukkola-Vuorinen A.
    Breast Cancer Res Treat; 2012 May 06; 133(1):179-88. PubMed ID: 21877141
    [Abstract] [Full Text] [Related]

  • 17. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
    Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.
    EMBO J; 2003 Aug 15; 22(16):4082-90. PubMed ID: 12912907
    [Abstract] [Full Text] [Related]

  • 18. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.
    Takeda K, Cowan A, Fong GH.
    Circulation; 2007 Aug 14; 116(7):774-81. PubMed ID: 17646578
    [Abstract] [Full Text] [Related]

  • 19. [Expression of hypoxia-inducible factor-1alpha and vessel endothelial growth factor in esophageal squamous cell carcinoma and clinico-pathological significance thereof].
    Yu ZT, Zhao HF, Shang XB.
    Zhonghua Yi Xue Za Zhi; 2008 Sep 16; 88(35):2465-9. PubMed ID: 19080625
    [Abstract] [Full Text] [Related]

  • 20. DNA methylation analysis of the HIF-1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas.
    Huang KT, Mikeska T, Dobrovic A, Fox SB.
    Histopathology; 2010 Sep 16; 57(3):451-60. PubMed ID: 20727020
    [Abstract] [Full Text] [Related]


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