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Journal Abstract Search

412 related items for PubMed ID: 16497228

  • 1. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
    Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J.
    Traffic; 2006 Mar; 7(3):354-64. PubMed ID: 16497228
    [Abstract] [Full Text] [Related]

  • 2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 3. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, Small DH.
    J Neurosci Res; 2003 Nov 01; 74(3):378-85. PubMed ID: 14598314
    [Abstract] [Full Text] [Related]

  • 4. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 01; 20(2):625-37. PubMed ID: 15936948
    [Abstract] [Full Text] [Related]

  • 5. COPI-mediated retrograde transport is required for efficient gamma-secretase cleavage of the amyloid precursor protein.
    Selivanova A, Winblad B, Farmery MR, Dantuma NP, Ankarcrona M.
    Biochem Biophys Res Commun; 2006 Nov 10; 350(1):220-6. PubMed ID: 16999935
    [Abstract] [Full Text] [Related]

  • 6. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 10; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 7. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 10; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 8. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA.
    J Neurochem; 2006 Mar 10; 96(5):1322-35. PubMed ID: 16478525
    [Abstract] [Full Text] [Related]

  • 9. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 10; 25(2):291-6. PubMed ID: 17071095
    [Abstract] [Full Text] [Related]

  • 10. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep 10; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 11. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
    Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.
    J Neurochem; 2004 Sep 10; 90(6):1402-13. PubMed ID: 15341524
    [Abstract] [Full Text] [Related]

  • 12. [Presenilins as a marker of Alzheimer's disease].
    Scheper W, van Gool WA.
    Ned Tijdschr Geneeskd; 1998 May 30; 142(22):1247-52. PubMed ID: 9749296
    [Abstract] [Full Text] [Related]

  • 13. Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells.
    Suga K, Saito A, Tomiyama T, Mori H, Akagawa K.
    J Neurochem; 2005 Jul 30; 94(2):425-39. PubMed ID: 15998293
    [Abstract] [Full Text] [Related]

  • 14. Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments.
    Lah JJ, Levey AI.
    Mol Cell Neurosci; 2000 Aug 30; 16(2):111-26. PubMed ID: 10924255
    [Abstract] [Full Text] [Related]

  • 15. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
    J Neurochem; 2004 Dec 30; 91(6):1260-74. PubMed ID: 15584903
    [Abstract] [Full Text] [Related]

  • 16. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
    Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y.
    Biochemistry; 2004 Oct 26; 43(42):13532-40. PubMed ID: 15491160
    [Abstract] [Full Text] [Related]

  • 17. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar 26; 57(3):446-53. PubMed ID: 17210196
    [Abstract] [Full Text] [Related]

  • 18. Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
    Wilson CA, Doms RW, Lee VM.
    J Neurosci Res; 2003 Nov 01; 74(3):361-9. PubMed ID: 14598312
    [Abstract] [Full Text] [Related]

  • 19. Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.
    Li L, Zhang X, Yang D, Luo G, Chen S, Le W.
    Neurobiol Aging; 2009 Jul 01; 30(7):1091-8. PubMed ID: 18063223
    [Abstract] [Full Text] [Related]

  • 20. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
    Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W.
    J Cell Biol; 2001 Aug 20; 154(4):731-40. PubMed ID: 11502763
    [Abstract] [Full Text] [Related]

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