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163 related items for PubMed ID: 16505244

  • 21. Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity.
    Araújo EP, De Souza CT, Gasparetti AL, Ueno M, Boschero AC, Saad MJ, Velloso LA.
    Endocrinology; 2005 Mar; 146(3):1428-37. PubMed ID: 15550510
    [Abstract] [Full Text] [Related]

  • 22. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
    Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB.
    Proc Natl Acad Sci U S A; 2001 Apr 10; 98(8):4640-5. PubMed ID: 11287630
    [Abstract] [Full Text] [Related]

  • 23. Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozocin-induced diabetic rats.
    Giorgino F, Logoluso F, Davalli AM, Napoli R, Laviola L, Hirshman MF, Horton ES, Weir GC, Smith RJ.
    Diabetes; 1999 Apr 10; 48(4):801-12. PubMed ID: 10102697
    [Abstract] [Full Text] [Related]

  • 24. Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise.
    Thong FS, Derave W, Kiens B, Graham TE, Ursø B, Wojtaszewski JF, Hansen BF, Richter EA.
    Diabetes; 2002 Mar 10; 51(3):583-90. PubMed ID: 11872654
    [Abstract] [Full Text] [Related]

  • 25. Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients.
    Miyazaki Y, He H, Mandarino LJ, DeFronzo RA.
    Diabetes; 2003 Aug 10; 52(8):1943-50. PubMed ID: 12882909
    [Abstract] [Full Text] [Related]

  • 26. Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.
    Song XM, Kawano Y, Krook A, Ryder JW, Efendic S, Roth RA, Wallberg-Henriksson H, Zierath JR.
    Diabetes; 1999 Mar 10; 48(3):664-70. PubMed ID: 10078575
    [Abstract] [Full Text] [Related]

  • 27. Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes.
    Meyer MM, Levin K, Grimmsmann T, Perwitz N, Eirich A, Beck-Nielsen H, Klein HH.
    Diabetes; 2002 Sep 10; 51(9):2691-7. PubMed ID: 12196460
    [Abstract] [Full Text] [Related]

  • 28. Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.
    Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM.
    Diabetes; 2005 Aug 10; 54(8):2351-9. PubMed ID: 16046301
    [Abstract] [Full Text] [Related]

  • 29. Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.
    Frøsig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF.
    Diabetes; 2007 Aug 10; 56(8):2093-102. PubMed ID: 17513702
    [Abstract] [Full Text] [Related]

  • 30. Regulation of IRS-1/SHP2 interaction and AKT phosphorylation in animal models of insulin resistance.
    Lima MH, Ueno M, Thirone AC, Rocha EM, Carvalho CR, Saad MJ.
    Endocrine; 2002 Jun 10; 18(1):1-12. PubMed ID: 12166618
    [Abstract] [Full Text] [Related]

  • 31. Insulin signaling in human skeletal muscle: time course and effect of exercise.
    Wojtaszewski JF, Hansen BF, Kiens B, Richter EA.
    Diabetes; 1997 Nov 10; 46(11):1775-81. PubMed ID: 9356025
    [Abstract] [Full Text] [Related]

  • 32. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes.
    Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB.
    J Clin Invest; 1999 Sep 10; 104(6):733-41. PubMed ID: 10491408
    [Abstract] [Full Text] [Related]

  • 33. Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle.
    Dokken BB, Sloniger JA, Henriksen EJ.
    Am J Physiol Endocrinol Metab; 2005 Jun 10; 288(6):E1188-94. PubMed ID: 15671078
    [Abstract] [Full Text] [Related]

  • 34. Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.
    Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI.
    Diabetes; 2008 Oct 10; 57(10):2644-51. PubMed ID: 18633112
    [Abstract] [Full Text] [Related]

  • 35. Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.
    Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y.
    Mol Cell Biol; 2004 Nov 10; 24(21):9668-81. PubMed ID: 15485932
    [Abstract] [Full Text] [Related]

  • 36. Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation.
    Frangioudakis G, Ye JM, Cooney GJ.
    Endocrinology; 2005 Dec 10; 146(12):5596-603. PubMed ID: 16150913
    [Abstract] [Full Text] [Related]

  • 37. Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells.
    Obanda DN, Cefalu WT.
    J Nutr Biochem; 2013 Aug 10; 24(8):1529-37. PubMed ID: 23481236
    [Abstract] [Full Text] [Related]

  • 38. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.
    Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI.
    J Clin Invest; 1999 Jan 10; 103(2):253-9. PubMed ID: 9916137
    [Abstract] [Full Text] [Related]

  • 39. Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.
    Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, Häring HU, Schleicher ED.
    J Biol Chem; 2006 Mar 17; 281(11):7060-7. PubMed ID: 16418171
    [Abstract] [Full Text] [Related]

  • 40. Delays in insulin signaling towards glucose disposal in human skeletal muscle.
    Grimmsmann T, Levin K, Meyer MM, Beck-Nielsen H, Klein HH.
    J Endocrinol; 2002 Mar 17; 172(3):645-51. PubMed ID: 11874713
    [Abstract] [Full Text] [Related]

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