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Journal Abstract Search

234 related items for PubMed ID: 16505485

  • 1. Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein.
    Maki N, Moitra K, Ghosh P, Dey S.
    J Biol Chem; 2006 Apr 21; 281(16):10769-77. PubMed ID: 16505485
    [Abstract] [Full Text] [Related]

  • 2. Modulator-induced interference in functional cross talk between the substrate and the ATP sites of human P-glycoprotein.
    Maki N, Moitra K, Silver C, Ghosh P, Chattopadhyay A, Dey S.
    Biochemistry; 2006 Feb 28; 45(8):2739-51. PubMed ID: 16489767
    [Abstract] [Full Text] [Related]

  • 3. Functionally similar vanadate-induced 8-azidoadenosine 5'-[alpha-(32)P]Diphosphate-trapped transition state intermediates of human P-glycoprotin are generated in the absence and presence of ATP hydrolysis.
    Sauna ZE, Smith MM, Muller M, Ambudkar SV.
    J Biol Chem; 2001 Jun 15; 276(24):21199-208. PubMed ID: 11287418
    [Abstract] [Full Text] [Related]

  • 4. Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes.
    Sauna ZE, Ambudkar SV.
    J Biol Chem; 2001 Apr 13; 276(15):11653-61. PubMed ID: 11154703
    [Abstract] [Full Text] [Related]

  • 5. Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.
    Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV.
    Proc Natl Acad Sci U S A; 1997 Sep 30; 94(20):10594-9. PubMed ID: 9380680
    [Abstract] [Full Text] [Related]

  • 6. Allosteric modulation of the human P-glycoprotein involves conformational changes mimicking catalytic transition intermediates.
    Ghosh P, Moitra K, Maki N, Dey S.
    Arch Biochem Biophys; 2006 Jun 01; 450(1):100-12. PubMed ID: 16624245
    [Abstract] [Full Text] [Related]

  • 7. Biochemical and pharmacological properties of an allosteric modulator site of the human P-glycoprotein (ABCB1).
    Maki N, Dey S.
    Biochem Pharmacol; 2006 Jul 14; 72(2):145-55. PubMed ID: 16729976
    [Abstract] [Full Text] [Related]

  • 8. Allosteric modulation of human P-glycoprotein. Inhibition of transport by preventing substrate translocation and dissociation.
    Maki N, Hafkemeyer P, Dey S.
    J Biol Chem; 2003 May 16; 278(20):18132-9. PubMed ID: 12642584
    [Abstract] [Full Text] [Related]

  • 9. Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein.
    Sauna ZE, Ambudkar SV.
    Proc Natl Acad Sci U S A; 2000 Mar 14; 97(6):2515-20. PubMed ID: 10716986
    [Abstract] [Full Text] [Related]

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  • 11. Evidence for the vectorial nature of drug (substrate)-stimulated ATP hydrolysis by human P-glycoprotein.
    Sauna ZE, Smith MM, Müller M, Ambudkar SV.
    J Biol Chem; 2001 Sep 07; 276(36):33301-4. PubMed ID: 11451943
    [Abstract] [Full Text] [Related]

  • 12. Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates.
    Kerr KM, Sauna ZE, Ambudkar SV.
    J Biol Chem; 2001 Mar 23; 276(12):8657-64. PubMed ID: 11121420
    [Abstract] [Full Text] [Related]

  • 13. P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site.
    Urbatsch IL, Sankaran B, Weber J, Senior AE.
    J Biol Chem; 1995 Aug 18; 270(33):19383-90. PubMed ID: 7642618
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  • 15. Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.
    Julien M, Gros P.
    Biochemistry; 2000 Apr 18; 39(15):4559-68. PubMed ID: 10758006
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  • 17. Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle.
    Qu Q, Russell PL, Sharom FJ.
    Biochemistry; 2003 Feb 04; 42(4):1170-7. PubMed ID: 12549939
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  • 19. Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).
    Sauna ZE, Müller M, Peng XH, Ambudkar SV.
    Biochemistry; 2002 Nov 26; 41(47):13989-4000. PubMed ID: 12437356
    [Abstract] [Full Text] [Related]

  • 20. Evidence for modulatory sites at the lipid-protein interface of the human multidrug transporter P-glycoprotein.
    Mandal D, Moitra K, Ghosh D, Xia D, Dey S.
    Biochemistry; 2012 Apr 03; 51(13):2852-66. PubMed ID: 22360349
    [Abstract] [Full Text] [Related]

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