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Journal Abstract Search

194 related items for PubMed ID: 1650764

  • 1. Selection of L cell sublines resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Shiraki K, Vonka V, De Clercq E, Rapp F.
    Intervirology; 1991; 32(4):228-33. PubMed ID: 1650764
    [Abstract] [Full Text] [Related]

  • 2. Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Docherty JJ, Dobson AT, Trimble JJ, Jennings BA.
    Intervirology; 1991; 32(5):308-15. PubMed ID: 1657822
    [Abstract] [Full Text] [Related]

  • 3. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
    Balzarini J, De Clercq E, Verbruggen A, Ayusawa D, Shimizu K, Seno T.
    Mol Pharmacol; 1987 Sep; 32(3):410-6. PubMed ID: 2823092
    [Abstract] [Full Text] [Related]

  • 4. Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on the proliferation of herpes simplex virus type 1-transformed and thymidine kinase-deficient mouse cells.
    Bubley G, Crumpacker C, De Clercq E, Schnipper L.
    Virology; 1983 Sep; 129(2):490-2. PubMed ID: 6312685
    [Abstract] [Full Text] [Related]

  • 5. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
    Balzarini J, De Clercq E, Verbruggen A, Ayusawa D, Seno T.
    Mol Pharmacol; 1985 Dec; 28(6):581-7. PubMed ID: 3001499
    [Abstract] [Full Text] [Related]

  • 6. Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
    Balzarini J, De Clercq E, Baumgartner H, Bodenteich M, Griengl H.
    Mol Pharmacol; 1990 Mar; 37(3):395-401. PubMed ID: 2156153
    [Abstract] [Full Text] [Related]

  • 7. Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
    Balzarini J, de Clercq E, Ayusawa D, Seno T.
    FEBS Lett; 1985 Jun 03; 185(1):95-100. PubMed ID: 2987041
    [Abstract] [Full Text] [Related]

  • 8. Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.
    Balzarini J, De Clercq E.
    Methods Find Exp Clin Pharmacol; 1989 Jun 03; 11(6):379-89. PubMed ID: 2545982
    [No Abstract] [Full Text] [Related]

  • 9. (E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
    Hamel W, Zirkel D, Mehdorn HM, Westphal M, Israel MA.
    Cancer Gene Ther; 2001 May 03; 8(5):388-96. PubMed ID: 11477459
    [Abstract] [Full Text] [Related]

  • 10. Low levels of herpes simplex virus thymidine- thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model.
    Coen DM, Irmiere AF, Jacobson JG, Kerns KM.
    Virology; 1989 Feb 03; 168(2):221-31. PubMed ID: 2536980
    [Abstract] [Full Text] [Related]

  • 11. Selective inhibition of the proliferation of herpes simplex virus type 1 thymidine kinase gene-transformed murine mammary FM3A carcinoma cells by (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds.
    Balzarini J, De Clercq E, Ayusawa D, Shimizu K, Seno T.
    Nucleic Acids Symp Ser; 1985 Feb 03; (16):283-6. PubMed ID: 3003708
    [Abstract] [Full Text] [Related]

  • 12. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
    Balzarini J, Bohman C, De Clercq E.
    J Biol Chem; 1993 Mar 25; 268(9):6332-7. PubMed ID: 8384209
    [Abstract] [Full Text] [Related]

  • 13. Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
    Grignet-Debrus C, Cool V, Baudson N, Degrève B, Balzarini J, De Leval L, Debrus S, Velu T, Calberg-Bacq CM.
    Cancer Gene Ther; 2000 Feb 25; 7(2):215-23. PubMed ID: 10770629
    [Abstract] [Full Text] [Related]

  • 14. Increased sensitivity of thymidine kinase-deficient (TK-) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds.
    Balzarini J, De Clercq E, Verbruggen A, Crumpacker C, Ayusawa D, Seno T.
    Anticancer Res; 1986 Feb 25; 6(5):1077-84. PubMed ID: 2432829
    [Abstract] [Full Text] [Related]

  • 15. Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Wilber BA, Docherty JJ.
    J Gen Virol; 1994 Jul 25; 75 ( Pt 7)():1743-7. PubMed ID: 8021603
    [Abstract] [Full Text] [Related]

  • 16. Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
    Degrève B, De Clercq E, Balzarini J.
    Gene Ther; 2000 Sep 25; 7(18):1543-52. PubMed ID: 11021592
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  • 20. Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Balzarini J, Baumgartner H, Bodenteich M, De Clercq E, Griengl H.
    J Med Chem; 1989 Aug 25; 32(8):1861-5. PubMed ID: 2547072
    [Abstract] [Full Text] [Related]

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