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286 related items for PubMed ID: 16507992

  • 1. Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation.
    Wang Z, Dillon TJ, Pokala V, Mishra S, Labudda K, Hunter B, Stork PJ.
    Mol Cell Biol; 2006 Mar; 26(6):2130-45. PubMed ID: 16507992
    [Abstract] [Full Text] [Related]

  • 2. Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP.
    Li Y, Dillon TJ, Takahashi M, Earley KT, Stork PJ.
    J Biol Chem; 2016 Oct 07; 291(41):21584-21595. PubMed ID: 27531745
    [Abstract] [Full Text] [Related]

  • 3. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
    Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Døskeland SO, Blank JL, Bos JL.
    Nat Cell Biol; 2002 Nov 07; 4(11):901-6. PubMed ID: 12402047
    [Abstract] [Full Text] [Related]

  • 4. EPAC activation inhibits acetaldehyde-induced activation and proliferation of hepatic stellate cell via Rap1.
    Yang Y, Yang F, Wu X, Lv X, Li J.
    Can J Physiol Pharmacol; 2016 May 07; 94(5):498-507. PubMed ID: 26854595
    [Abstract] [Full Text] [Related]

  • 5. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
    de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL.
    J Biol Chem; 2000 Jul 07; 275(27):20829-36. PubMed ID: 10777494
    [Abstract] [Full Text] [Related]

  • 6. The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
    Misra UK, Kaczowka S, Pizzo SV.
    Cell Signal; 2008 Aug 07; 20(8):1459-70. PubMed ID: 18495429
    [Abstract] [Full Text] [Related]

  • 7. The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane.
    Li Y, Asuri S, Rebhun JF, Castro AF, Paranavitana NC, Quilliam LA.
    J Biol Chem; 2006 Feb 03; 281(5):2506-14. PubMed ID: 16316996
    [Abstract] [Full Text] [Related]

  • 8. PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells.
    Obara Y, Labudda K, Dillon TJ, Stork PJ.
    J Cell Sci; 2004 Dec 01; 117(Pt 25):6085-94. PubMed ID: 15546918
    [Abstract] [Full Text] [Related]

  • 9. Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP.
    Takahashi M, Li Y, Dillon TJ, Stork PJ.
    J Biol Chem; 2017 Jan 27; 292(4):1449-1461. PubMed ID: 28003362
    [Abstract] [Full Text] [Related]

  • 10. Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap1-extracellular signal-regulated kinase pathway.
    Grewal SS, Fass DM, Yao H, Ellig CL, Goodman RH, Stork PJ.
    J Biol Chem; 2000 Nov 03; 275(44):34433-41. PubMed ID: 10950954
    [Abstract] [Full Text] [Related]

  • 11. The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages.
    Bryn T, Mahic M, Enserink JM, Schwede F, Aandahl EM, Taskén K.
    J Immunol; 2006 Jun 15; 176(12):7361-70. PubMed ID: 16751380
    [Abstract] [Full Text] [Related]

  • 12. Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.
    Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL.
    J Cell Biol; 2003 Feb 17; 160(4):487-93. PubMed ID: 12578910
    [Abstract] [Full Text] [Related]

  • 13. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
    de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL.
    Nature; 1998 Dec 03; 396(6710):474-7. PubMed ID: 9853756
    [Abstract] [Full Text] [Related]

  • 14. The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells.
    Obara Y, Horgan AM, Stork PJ.
    J Neurochem; 2007 Apr 03; 101(2):470-82. PubMed ID: 17254020
    [Abstract] [Full Text] [Related]

  • 15. Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis.
    Hochbaum D, Hong K, Barila G, Ribeiro-Neto F, Altschuler DL.
    J Biol Chem; 2008 Feb 22; 283(8):4464-8. PubMed ID: 18063584
    [Abstract] [Full Text] [Related]

  • 16. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells.
    Roscioni SS, Kistemaker LE, Menzen MH, Elzinga CR, Gosens R, Halayko AJ, Meurs H, Schmidt M.
    Respir Res; 2009 Sep 29; 10(1):88. PubMed ID: 19788733
    [Abstract] [Full Text] [Related]

  • 17. CAMP activates Rap1 in differentiating mouse male germ cells: a new signaling pathway mediated by the cAMP-activated exchange factor Epac?
    Berruti G.
    Cell Mol Biol (Noisy-le-grand); 2003 May 29; 49(3):381-8. PubMed ID: 12887090
    [Abstract] [Full Text] [Related]

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  • 19. Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways.
    Li J, O'Connor KL, Cheng X, Mei FC, Uchida T, Townsend CM, Evers BM.
    Mol Endocrinol; 2007 Jan 29; 21(1):159-71. PubMed ID: 17068197
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