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186 related items for PubMed ID: 16511862

  • 1. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures.
    Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE.
    J Neurosci Res; 2006 May 15; 83(7):1262-70. PubMed ID: 16511862
    [Abstract] [Full Text] [Related]

  • 2. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
    Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.
    Biochemistry; 2005 May 03; 44(17):6513-25. PubMed ID: 15850385
    [Abstract] [Full Text] [Related]

  • 3. Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation.
    Cordes CM, Bennett RG, Siford GL, Hamel FG.
    Biochem Pharmacol; 2009 Mar 15; 77(6):1064-73. PubMed ID: 19154729
    [Abstract] [Full Text] [Related]

  • 4. Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells.
    Gao W, Eisenhauer PB, Conn K, Lynch JA, Wells JM, Ullman MD, McKee A, Thatte HS, Fine RE.
    Neurosci Lett; 2004 Nov 16; 371(1):6-11. PubMed ID: 15500957
    [Abstract] [Full Text] [Related]

  • 5. Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-β peptide in mouse brain capillary endothelial cells.
    Ito S, Ohtsuki S, Murata S, Katsukura Y, Suzuki H, Funaki M, Tachikawa M, Terasaki T.
    J Alzheimers Dis; 2014 Nov 16; 38(1):185-200. PubMed ID: 23948938
    [Abstract] [Full Text] [Related]

  • 6. Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders.
    Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM.
    Neurobiol Aging; 2005 May 16; 26(5):645-54. PubMed ID: 15708439
    [Abstract] [Full Text] [Related]

  • 7. Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology.
    Vepsäläinen S, Hiltunen M, Helisalmi S, Wang J, van Groen T, Tanila H, Soininen H.
    Neurosci Lett; 2008 Jun 20; 438(2):216-20. PubMed ID: 18455870
    [Abstract] [Full Text] [Related]

  • 8. Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity.
    Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M.
    J Mol Biol; 2009 Feb 06; 385(5):1556-67. PubMed ID: 19073193
    [Abstract] [Full Text] [Related]

  • 9. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease.
    Zhao Z, Xiang Z, Haroutunian V, Buxbaum JD, Stetka B, Pasinetti GM.
    Neurobiol Aging; 2007 Jun 06; 28(6):824-30. PubMed ID: 16769157
    [Abstract] [Full Text] [Related]

  • 10. Insulin acts intracellularly on proteasomes through insulin-degrading enzyme.
    Duckworth WC, Bennett RG, Hamel FG.
    Biochem Biophys Res Commun; 1998 Mar 17; 244(2):390-4. PubMed ID: 9514933
    [Abstract] [Full Text] [Related]

  • 11. Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing.
    Fawcett J, Permana PA, Levy JL, Duckworth WC.
    Arch Biochem Biophys; 2007 Dec 01; 468(1):128-33. PubMed ID: 17964527
    [Abstract] [Full Text] [Related]

  • 12. Insulin-degrading enzyme.
    Authier F, Posner BI, Bergeron JJ.
    Clin Invest Med; 1996 Jun 01; 19(3):149-60. PubMed ID: 8724818
    [Abstract] [Full Text] [Related]

  • 13. ApoE 4 reduces the expression of Abeta degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons.
    Du J, Chang J, Guo S, Zhang Q, Wang Z.
    Neurosci Lett; 2009 Oct 23; 464(2):140-5. PubMed ID: 19616072
    [Abstract] [Full Text] [Related]

  • 14. Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.
    Wilhelmus MM, Boelens WC, Otte-Höller I, Kamps B, de Waal RM, Verbeek MM.
    Brain Res; 2006 May 17; 1089(1):67-78. PubMed ID: 16635482
    [Abstract] [Full Text] [Related]

  • 15. Down-regulation of insulin-degrading enzyme by presenilin 1 V97L mutant potentially underlies increased levels of amyloid beta 42.
    Qin W, Jia J.
    Eur J Neurosci; 2008 May 17; 27(9):2425-32. PubMed ID: 18445230
    [Abstract] [Full Text] [Related]

  • 16. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
    Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.
    J Neurosci; 2000 Mar 01; 20(5):1657-65. PubMed ID: 10684867
    [Abstract] [Full Text] [Related]

  • 17. A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes.
    Nakagawa S, Deli MA, Kawaguchi H, Shimizudani T, Shimono T, Kittel A, Tanaka K, Niwa M.
    Neurochem Int; 2009 Mar 01; 54(3-4):253-63. PubMed ID: 19111869
    [Abstract] [Full Text] [Related]

  • 18. Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila.
    Tsuda M, Kobayashi T, Matsuo T, Aigaki T.
    FEBS Lett; 2010 Jul 02; 584(13):2916-20. PubMed ID: 20493190
    [Abstract] [Full Text] [Related]

  • 19. [Relationship between insulin-degrading enzyme activity and insulin sensitivity in cell model of insulin-resistance].
    Li CZ, Zhang SH, Shu CD, Ren W.
    Di Yi Jun Yi Da Xue Xue Bao; 2002 Feb 02; 22(2):151-4. PubMed ID: 12390813
    [Abstract] [Full Text] [Related]

  • 20. Toward prevention of Alzheimers disease--potential nutraceutical strategies for suppressing the production of amyloid beta peptides.
    McCarty MF.
    Med Hypotheses; 2006 Feb 02; 67(4):682-97. PubMed ID: 16828233
    [Abstract] [Full Text] [Related]

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