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198 related items for PubMed ID: 16545584

  • 1. Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse.
    Booth-Genthe CL, Louie SW, Carlini EJ, Li B, Leake BF, Eisenhandler R, Hochman JH, Mei Q, Kim RB, Rushmore TH, Yamazaki M.
    J Pharmacol Toxicol Methods; 2006; 54(1):78-89. PubMed ID: 16545584
    [Abstract] [Full Text] [Related]

  • 2. Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.
    Takeuchi T, Yoshitomi S, Higuchi T, Ikemoto K, Niwa S, Ebihara T, Katoh M, Yokoi T, Asahi S.
    Pharm Res; 2006 Jul; 23(7):1460-72. PubMed ID: 16779700
    [Abstract] [Full Text] [Related]

  • 3. Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.
    Katoh M, Suzuyama N, Takeuchi T, Yoshitomi S, Asahi S, Yokoi T.
    J Pharm Sci; 2006 Dec; 95(12):2673-83. PubMed ID: 16892207
    [Abstract] [Full Text] [Related]

  • 4. Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice.
    Uchida Y, Ohtsuki S, Kamiie J, Terasaki T.
    J Pharmacol Exp Ther; 2011 Nov; 339(2):579-88. PubMed ID: 21828264
    [Abstract] [Full Text] [Related]

  • 5. Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds.
    Enokizono J, Kusuhara H, Ose A, Schinkel AH, Sugiyama Y.
    Drug Metab Dispos; 2008 Jun; 36(6):995-1002. PubMed ID: 18322075
    [Abstract] [Full Text] [Related]

  • 6. Characterization of phosphine complexes of technetium(III) as transport substrates of the multidrug resistance P-glycoprotein and functional markers of P-glycoprotein at the blood-brain barrier.
    Luker GD, Rao VV, Crankshaw CL, Dahlheimer J, Piwnica-Worms D.
    Biochemistry; 1997 Nov 18; 36(46):14218-27. PubMed ID: 9369495
    [Abstract] [Full Text] [Related]

  • 7. Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
    Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Löscher W.
    Neuropharmacology; 2007 Feb 18; 52(2):333-46. PubMed ID: 17045309
    [Abstract] [Full Text] [Related]

  • 8. Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
    Tang SC, Nguyen LN, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.
    Int J Cancer; 2014 Mar 15; 134(6):1484-94. PubMed ID: 24037730
    [Abstract] [Full Text] [Related]

  • 9. Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice.
    Erdő F, Nagy I, Tóth B, Bui A, Molnár É, Tímár Z, Magnan R, Krajcsi P.
    Brain Res Bull; 2017 Jun 15; 132():232-236. PubMed ID: 28629814
    [Abstract] [Full Text] [Related]

  • 10. Cytofluorimetric analysis of a renal tubular cell line and its resistant counterpart.
    Rosati A, Decorti G, Klugmann FB, Candussio L, Granzotto M, Melato M, Giraldi T.
    Anticancer Res; 2000 Jun 15; 20(5B):3403-10. PubMed ID: 11131640
    [Abstract] [Full Text] [Related]

  • 11. In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results.
    Yamazaki M, Neway WE, Ohe T, Chen I, Rowe JF, Hochman JH, Chiba M, Lin JH.
    J Pharmacol Exp Ther; 2001 Mar 15; 296(3):723-35. PubMed ID: 11181899
    [Abstract] [Full Text] [Related]

  • 12. P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.
    Durmus S, Xu N, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.
    Pharmacol Res; 2013 Oct 15; 76():9-16. PubMed ID: 23827160
    [Abstract] [Full Text] [Related]

  • 13. Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
    Kodaira H, Kusuhara H, Ushiki J, Fuse E, Sugiyama Y.
    J Pharmacol Exp Ther; 2010 Jun 15; 333(3):788-96. PubMed ID: 20304939
    [Abstract] [Full Text] [Related]

  • 14. Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.
    Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD.
    Mol Pharmacol; 2000 Jan 15; 57(1):24-35. PubMed ID: 10617675
    [Abstract] [Full Text] [Related]

  • 15. Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes.
    Joseph B, Bhargava KK, Malhi H, Schilsky ML, Jain D, Palestro CJ, Gupta S.
    Eur J Nucl Med Mol Imaging; 2003 Jul 15; 30(7):1024-31. PubMed ID: 12536246
    [Abstract] [Full Text] [Related]

  • 16. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation.
    Maeng HJ, Kim MH, Jin HE, Shin SM, Tsuruo T, Kim SG, Kim DD, Shim CK, Chung SJ.
    Drug Metab Dispos; 2007 Nov 15; 35(11):1996-2005. PubMed ID: 17664251
    [Abstract] [Full Text] [Related]

  • 17. Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).
    Kort A, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH.
    Pharmacol Res; 2015 Dec 15; 102():200-7. PubMed ID: 26361725
    [Abstract] [Full Text] [Related]

  • 18. Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir.
    Bardelmeijer HA, Ouwehand M, Buckle T, Huisman MT, Schellens JH, Beijnen JH, van Tellingen O.
    Cancer Res; 2002 Nov 01; 62(21):6158-64. PubMed ID: 12414642
    [Abstract] [Full Text] [Related]

  • 19. Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation.
    Yousif S, Chaves C, Potin S, Margaill I, Scherrmann JM, Declèves X.
    J Neurochem; 2012 Nov 01; 123(4):491-503. PubMed ID: 22845665
    [Abstract] [Full Text] [Related]

  • 20. Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier.
    Poller B, Wagenaar E, Tang SC, Schinkel AH.
    Mol Pharm; 2011 Apr 04; 8(2):571-82. PubMed ID: 21309545
    [Abstract] [Full Text] [Related]

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