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Journal Abstract Search

177 related items for PubMed ID: 16548522

  • 21.
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  • 22. The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.
    Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K.
    Proc Natl Acad Sci U S A; 2002 Feb 05; 99(3):1365-70. PubMed ID: 11805291
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  • 23. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 05; 92(2):294-301. PubMed ID: 15663477
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  • 24. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
    Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H.
    Genes Cells; 2006 Jan 05; 11(1):83-93. PubMed ID: 16371134
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  • 27. Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.
    Boo JH, Sohn JH, Kim JE, Song H, Mook-Jung I.
    Biochem Biophys Res Commun; 2008 Aug 08; 372(4):913-7. PubMed ID: 18538664
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  • 28. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.
    Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y.
    J Neurosci; 2005 Jan 12; 25(2):436-45. PubMed ID: 15647487
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  • 29. Abeta 11-40/42 production without gamma-secretase epsilon-site cleavage.
    Kume H, Kametani F.
    Biochem Biophys Res Commun; 2006 Nov 03; 349(4):1356-60. PubMed ID: 16979587
    [Abstract] [Full Text] [Related]

  • 30. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
    Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.
    J Biol Chem; 2008 Jun 13; 283(24):16488-96. PubMed ID: 18430735
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  • 31.
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  • 32. Presenilin endoproteolysis is an intramolecular cleavage.
    Brunkan AL, Martinez M, Walker ES, Goate AM.
    Mol Cell Neurosci; 2005 May 13; 29(1):65-73. PubMed ID: 15866047
    [Abstract] [Full Text] [Related]

  • 33. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage.
    Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H.
    Biochemistry; 2004 May 11; 43(18):5352-9. PubMed ID: 15122901
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  • 34. Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase.
    Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
    Neurodegener Dis; 2008 May 11; 5(3-4):160-2. PubMed ID: 18322378
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  • 35. Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
    Wilson CA, Doms RW, Lee VM.
    J Neurosci Res; 2003 Nov 01; 74(3):361-9. PubMed ID: 14598312
    [Abstract] [Full Text] [Related]

  • 36. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
    Sudoh S, Hua G, Kawamura Y, Maruyama K, Komano H, Yanagisawa K.
    Eur J Biochem; 2000 Apr 01; 267(7):2036-45. PubMed ID: 10727943
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  • 37. Protease digestion indicates that endogenous presenilin 1 is present in at least two physical forms.
    Oh YS, Turner RJ.
    Biochem Biophys Res Commun; 2006 Jul 21; 346(1):330-4. PubMed ID: 16756946
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  • 38. A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
    Amtul Z, Lewis PA, Piper S, Crook R, Baker M, Findlay K, Singleton A, Hogg M, Younkin L, Younkin SG, Hardy J, Hutton M, Boeve BF, Tang-Wai D, Golde TE.
    Neurobiol Dis; 2002 Mar 21; 9(2):269-73. PubMed ID: 11895378
    [Abstract] [Full Text] [Related]

  • 39. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.
    Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y.
    J Biol Chem; 2006 May 26; 281(21):14776-86. PubMed ID: 16595682
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  • 40. Purification and characterization of the human gamma-secretase complex.
    Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS.
    Biochemistry; 2004 Aug 03; 43(30):9774-89. PubMed ID: 15274632
    [Abstract] [Full Text] [Related]

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