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516 related items for PubMed ID: 16551868

  • 1. A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
    Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB.
    Clin Cancer Res; 2006 Mar 15; 12(6):1828-38. PubMed ID: 16551868
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  • 4. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells.
    Stadheim TA, Suh N, Ganju N, Sporn MB, Eastman A.
    J Biol Chem; 2002 May 10; 277(19):16448-55. PubMed ID: 11880365
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  • 5. Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.
    Takada Y, Andreeff M, Aggarwal BB.
    Blood; 2005 Jul 15; 106(2):641-9. PubMed ID: 15811958
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  • 7. Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
    Takada Y, Ichikawa H, Badmaev V, Aggarwal BB.
    J Immunol; 2006 Mar 01; 176(5):3127-40. PubMed ID: 16493072
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  • 9. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
    Ichikawa H, Takada Y, Murakami A, Aggarwal BB.
    J Immunol; 2005 Jun 01; 174(11):7383-92. PubMed ID: 15905586
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  • 10. 3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.
    Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB.
    J Biol Chem; 2012 Jan 02; 287(1):245-256. PubMed ID: 22065587
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  • 11. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.
    Shishodia S, Aggarwal BB.
    J Biol Chem; 2004 Nov 05; 279(45):47148-58. PubMed ID: 15322087
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  • 12. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
    Sandur SK, Ichikawa H, Sethi G, Ahn KS, Aggarwal BB.
    J Biol Chem; 2006 Jun 23; 281(25):17023-17033. PubMed ID: 16624823
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  • 14. Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation.
    Sung B, Pandey MK, Aggarwal BB.
    Mol Pharmacol; 2007 Jun 23; 71(6):1703-14. PubMed ID: 17387141
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  • 15. Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.
    Takada Y, Aggarwal BB.
    J Immunol; 2003 Sep 15; 171(6):3278-86. PubMed ID: 12960358
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  • 16. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
    Sethi G, Ahn KS, Pandey MK, Aggarwal BB.
    Blood; 2007 Apr 01; 109(7):2727-35. PubMed ID: 17110449
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  • 17. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
    Ahn KS, Sethi G, Shishodia S, Sung B, Arbiser JL, Aggarwal BB.
    Mol Cancer Res; 2006 Sep 01; 4(9):621-33. PubMed ID: 16966432
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  • 18. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis.
    Takada Y, Singh S, Aggarwal BB.
    J Biol Chem; 2004 Apr 09; 279(15):15096-104. PubMed ID: 14711835
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  • 19. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
    Ahn KS, Sethi G, Chao TH, Neuteboom ST, Chaturvedi MM, Palladino MA, Younes A, Aggarwal BB.
    Blood; 2007 Oct 01; 110(7):2286-95. PubMed ID: 17609425
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  • 20. Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
    Ahmad R, Raina D, Meyer C, Kharbanda S, Kufe D.
    J Biol Chem; 2006 Nov 24; 281(47):35764-9. PubMed ID: 16998237
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