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128 related items for PubMed ID: 16554371
1. Identification of a novel in vitro metabonate from liver microsomal incubations. Li C, Surapaneni S, Zeng Q, Marquez B, Chow D, Kumar G. Drug Metab Dispos; 2006 Jun; 34(6):901-5. PubMed ID: 16554371 [Abstract] [Full Text] [Related]
2. Liquid chromatography/nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry identification of novel metabolites of the multidrug resistance modulator LY335979 in rat bile and human liver microsomal incubations. Ehlhardt WJ, Woodland JM, Baughman TM, Vandenbranden M, Wrighton SA, Kroin JS, Norman BH, Maple SR. Drug Metab Dispos; 1998 Jan; 26(1):42-51. PubMed ID: 9443851 [Abstract] [Full Text] [Related]
3. Methanol solvent may cause increased apparent metabolic instability in in vitro assays. Yin H, Tran P, Greenberg GE, Fischer V. Drug Metab Dispos; 2001 Feb; 29(2):185-93. PubMed ID: 11159810 [Abstract] [Full Text] [Related]
4. o-Hydroxyphenylethanol, a novel lactone ring-opened metabolite of coumarin. Norman RL, Wood AW. Drug Metab Dispos; 1984 Feb; 12(5):543-9. PubMed ID: 6209076 [Abstract] [Full Text] [Related]
5. Structural characterization of novel adenine dinucleotide phosphate conjugates of imatinib in incubations with rat and human liver microsomes. Ma S, Subramanian R, Xu Y, Schrag M, Shou M. Drug Metab Dispos; 2008 Dec; 36(12):2414-8. PubMed ID: 18799804 [Abstract] [Full Text] [Related]
6. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans. Lang D, Freudenberger C, Weinz C. Drug Metab Dispos; 2009 May; 37(5):1046-55. PubMed ID: 19196846 [Abstract] [Full Text] [Related]
7. High-resolution mass spectrometry elucidates metabonate (false metabolite) formation from alkylamine drugs during in vitro metabolite profiling. Barbara JE, Kazmi F, Muranjan S, Toren PC, Parkinson A. Drug Metab Dispos; 2012 Oct; 40(10):1966-75. PubMed ID: 22798552 [Abstract] [Full Text] [Related]
8. CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance. Prakash C, Wang W, O'Connell T, Johnson KA. Drug Metab Dispos; 2008 Oct; 36(10):2093-103. PubMed ID: 18653741 [Abstract] [Full Text] [Related]
9. Metabolite identification via LC-SPE-NMR-MS of the in vitro biooxidation products of a lead mGlu5 allosteric antagonist and impact on the improvement of metabolic stability in the series. Ceccarelli SM, Schlotterbeck G, Boissin P, Binder M, Buettelmann B, Hanlon S, Jaeschke G, Kolczewski S, Kupfer E, Peters JU, Porter RH, Prinssen EP, Rueher M, Ruf I, Spooren W, Stämpfli A, Vieira E. ChemMedChem; 2008 Jan; 3(1):136-44. PubMed ID: 17994660 [Abstract] [Full Text] [Related]
10. The metabolism of avermectins B1a, H2B1a, and H2B1b by liver microsomes. Miwa GT, Walsh JS, VandenHeuvel WJ, Arison B, Sestokas E, Buhs R, Rosegay A, Avermitilis S, Lu AY, Walsh MA, Walker RW, Taub R, Jacob TA. Drug Metab Dispos; 1982 Jan; 10(3):268-74. PubMed ID: 6125361 [Abstract] [Full Text] [Related]
11. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine. Zhao SX, Dalvie DK, Kelly JM, Soglia JR, Frederick KS, Smith EB, Obach RS, Kalgutkar AS. Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785 [Abstract] [Full Text] [Related]
12. Characterization of cyanide-trapped methylated metabonates formed during reactive drug metabolite screening in vitro. Rousu T, Tolonen A. Rapid Commun Mass Spectrom; 2011 May 30; 25(10):1382-90. PubMed ID: 21504003 [Abstract] [Full Text] [Related]
13. Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap. Gao H, Materne OL, Howe DL, Brummel CL. Rapid Commun Mass Spectrom; 2007 May 30; 21(22):3683-93. PubMed ID: 17937450 [Abstract] [Full Text] [Related]
14. Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists. Tang W, Stearns RA, Wang RW, Miller RR, Chen Q, Ngui J, Bakshi RK, Nargund RP, Dean DC, Baillie TA. Xenobiotica; 2008 Nov 30; 38(11):1437-51. PubMed ID: 18841517 [Abstract] [Full Text] [Related]
15. Biotransformation of lithocholic acid by rat hepatic microsomes: metabolite analysis by liquid chromatography/mass spectrometry. Deo AK, Bandiera SM. Drug Metab Dispos; 2008 Feb 30; 36(2):442-51. PubMed ID: 18039809 [Abstract] [Full Text] [Related]
16. Metabolism of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): identification of an unusual N-acetylglucosamine conjugate in the cynomolgus monkey. Johnson BM, Kamath AV, Leet JE, Liu X, Bhide RS, Tejwani RW, Zhang Y, Qian L, Wei DD, Lombardo LJ, Shu YZ. Drug Metab Dispos; 2008 Dec 30; 36(12):2475-83. PubMed ID: 18787055 [Abstract] [Full Text] [Related]
17. In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide. Lin CC, Wong BK, Burgey CS, Gibson CR, Singh R. J Pharm Biomed Anal; 2005 Oct 04; 39(5):1014-20. PubMed ID: 16023819 [Abstract] [Full Text] [Related]
18. In vivo and in vitro metabolism of lefucoxib in rats. Bi X, Meng Z, Chen H, Zhu X, Dou G. J Pharm Biomed Anal; 2008 Sep 10; 48(1):134-9. PubMed ID: 18538525 [Abstract] [Full Text] [Related]
19. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry. Erve JC, Vashishtha SC, DeMaio W, Talaat RE. Drug Metab Dispos; 2007 Jun 10; 35(6):908-16. PubMed ID: 17353349 [Abstract] [Full Text] [Related]
20. Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine. Zhou H, Jiang H, Yao T, Zeng S. Rapid Commun Mass Spectrom; 2007 Jun 10; 21(13):2120-8. PubMed ID: 17546644 [Abstract] [Full Text] [Related] Page: [Next] [New Search]