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213 related items for PubMed ID: 16562881

  • 1. Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions.
    Wu TK, Yu MT, Liu YT, Chang CH, Wang HJ, Diau EW.
    Org Lett; 2006 Mar 30; 8(7):1319-22. PubMed ID: 16562881
    [Abstract] [Full Text] [Related]

  • 2. Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions.
    Wu TK, Liu YT, Chang CH, Yu MT, Wang HJ.
    J Am Chem Soc; 2006 May 17; 128(19):6414-9. PubMed ID: 16683806
    [Abstract] [Full Text] [Related]

  • 3. Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions.
    Wu TK, Liu YT, Chiu FH, Chang CH.
    Org Lett; 2006 Oct 12; 8(21):4691-4. PubMed ID: 17020279
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  • 6. Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase: a chemistry-biology interdisciplinary study of the protein's structure-function-reaction mechanism relationships.
    Wu TK, Chang CH, Liu YT, Wang TT.
    Chem Rec; 2008 Oct 12; 8(5):302-25. PubMed ID: 18956480
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  • 7. Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17α/β-exocyclic side chain stereochemistry.
    Wu TK, Chang YC, Liu YT, Chang CH, Wen HY, Li WH, Shie WS.
    Org Biomol Chem; 2011 Feb 21; 9(4):1092-7. PubMed ID: 21157613
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  • 9. Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase.
    Liu YT, Hu TC, Chang CH, Shie WS, Wu TK.
    Org Lett; 2012 Oct 19; 14(20):5222-5. PubMed ID: 23043506
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  • 10. Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions.
    Wu TK, Wang TT, Chang CH, Liu YT, Shie WS.
    Org Lett; 2008 Nov 06; 10(21):4959-62. PubMed ID: 18842050
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  • 11. Steric bulk at position 454 in Saccharomyces cerevisiae lanosterol synthase influences B-ring formation but not deprotonation.
    Joubert BM, Hua L, Matsuda SP.
    Org Lett; 2000 Feb 10; 2(3):339-41. PubMed ID: 10814317
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  • 12. Catalytic mechanism and product specificity of oxidosqualene-lanosterol cyclase: a QM/MM study.
    Tian BX, Eriksson LA.
    J Phys Chem B; 2012 Nov 29; 116(47):13857-62. PubMed ID: 23130825
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  • 13. Oxidosqualene cyclase second-sphere residues profoundly influence the product profile.
    Lodeiro S, Segura MJ, Stahl M, Schulz-Gasch T, Matsuda SP.
    Chembiochem; 2004 Nov 05; 5(11):1581-5. PubMed ID: 15515077
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  • 14. Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis.
    Segura MJ, Lodeiro S, Meyer MM, Patel AJ, Matsuda SP.
    Org Lett; 2002 Dec 12; 4(25):4459-62. PubMed ID: 12465912
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  • 15. Enzymatic formation of multiple triterpenes by mutation of tyrosine 510 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae.
    Wu TK, Chang CH.
    Chembiochem; 2004 Dec 03; 5(12):1712-5. PubMed ID: 15508118
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  • 16. Mechanistic insights into oxidosqualene cyclizations through homology modeling.
    Schulz-Gasch T, Stahl M.
    J Comput Chem; 2003 Apr 30; 24(6):741-53. PubMed ID: 12666166
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  • 17. Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase.
    Kimura M, Kushiro T, Shibuya M, Ebizuka Y, Abe I.
    Biochem Biophys Res Commun; 2010 Jan 01; 391(1):899-902. PubMed ID: 19951700
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  • 18. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.
    Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A.
    Nature; 2004 Nov 04; 432(7013):118-22. PubMed ID: 15525992
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  • 19. The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid.
    Chang CH, Chen YC, Tseng SW, Liu YT, Wen HY, Li WH, Huang CY, Ko CY, Wang TT, Wu TK.
    Biochimie; 2012 Nov 04; 94(11):2376-81. PubMed ID: 22732192
    [Abstract] [Full Text] [Related]

  • 20. Steric bulk at cycloartenol synthase position 481 influences cyclization and deprotonation.
    Matsuda SP, Darr LB, Hart EA, Herrera JB, McCann KE, Meyer MM, Pang J, Schepmann HG.
    Org Lett; 2000 Jul 27; 2(15):2261-3. PubMed ID: 10930258
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