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205 related items for PubMed ID: 16574739

  • 1. Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation.
    Nawaratne R, Gray A, Jørgensen CH, Downes CP, Siddle K, Sethi JK.
    Mol Endocrinol; 2006 Aug; 20(8):1838-52. PubMed ID: 16574739
    [Abstract] [Full Text] [Related]

  • 2. Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance.
    Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ.
    J Biol Chem; 2005 Jun 17; 280(24):23173-83. PubMed ID: 15849359
    [Abstract] [Full Text] [Related]

  • 3. Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.
    Jiang G, Dallas-Yang Q, Liu F, Moller DE, Zhang BB.
    J Biol Chem; 2003 Jan 03; 278(1):180-6. PubMed ID: 12409308
    [Abstract] [Full Text] [Related]

  • 4. Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).
    Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Häring HU.
    Diabetologia; 1998 Jul 03; 41(7):833-8. PubMed ID: 9686926
    [Abstract] [Full Text] [Related]

  • 5. PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function.
    Greene MW, Ruhoff MS, Roth RA, Kim JA, Quon MJ, Krause JA.
    Biochem Biophys Res Commun; 2006 Oct 27; 349(3):976-86. PubMed ID: 16970908
    [Abstract] [Full Text] [Related]

  • 6. Interactions between protein kinase C and pleckstrin homology domains. Inhibition by phosphatidylinositol 4,5-bisphosphate and phorbol 12-myristate 13-acetate.
    Yao L, Suzuki H, Ozawa K, Deng J, Lehel C, Fukamachi H, Anderson WB, Kawakami Y, Kawakami T.
    J Biol Chem; 1997 May 16; 272(20):13033-9. PubMed ID: 9148913
    [Abstract] [Full Text] [Related]

  • 7. 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
    Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T.
    J Biol Chem; 1997 Oct 03; 272(40):25267-74. PubMed ID: 9312143
    [Abstract] [Full Text] [Related]

  • 8. Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.
    Lee S, Lynn EG, Kim JA, Quon MJ.
    Endocrinology; 2008 May 03; 149(5):2451-8. PubMed ID: 18202124
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
    Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J.
    Mol Endocrinol; 2004 Aug 03; 18(8):2024-34. PubMed ID: 15143153
    [Abstract] [Full Text] [Related]

  • 10. In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites.
    Sommerfeld MR, Metzger S, Stosik M, Tennagels N, Eckel J.
    Biochemistry; 2004 May 18; 43(19):5888-901. PubMed ID: 15134463
    [Abstract] [Full Text] [Related]

  • 11. Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.
    Müssig K, Staiger H, Fiedler H, Moeschel K, Beck A, Kellerer M, Häring HU.
    J Biol Chem; 2005 Sep 23; 280(38):32693-9. PubMed ID: 16055440
    [Abstract] [Full Text] [Related]

  • 12. Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes.
    Müssig K, Fiedler H, Staiger H, Weigert C, Lehmann R, Schleicher ED, Häring HU.
    Biochem Biophys Res Commun; 2005 Sep 30; 335(3):819-25. PubMed ID: 16099431
    [Abstract] [Full Text] [Related]

  • 13. A novel insulin receptor substrate protein, xIRS-u, potentiates insulin signaling: functional importance of its pleckstrin homology domain.
    Ohan N, Bayaa M, Kumar P, Zhu L, Liu XJ.
    Mol Endocrinol; 1998 Aug 30; 12(8):1086-98. PubMed ID: 9717835
    [Abstract] [Full Text] [Related]

  • 14. Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1.
    Kaburagi Y, Satoh S, Yamamoto-Honda R, Ito T, Ueki K, Akanuma Y, Sekihara H, Kimura S, Kadowaki T.
    Diabetologia; 2001 Aug 30; 44(8):992-1004. PubMed ID: 11484076
    [Abstract] [Full Text] [Related]

  • 15. Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.
    Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y.
    Mol Cell Biol; 2004 Nov 30; 24(21):9668-81. PubMed ID: 15485932
    [Abstract] [Full Text] [Related]

  • 16. Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.
    De Fea K, Roth RA.
    Biochemistry; 1997 Oct 21; 36(42):12939-47. PubMed ID: 9335553
    [Abstract] [Full Text] [Related]

  • 17. Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.
    Batty IH, Fleming IN, Downes CP.
    Biochem J; 2004 May 01; 379(Pt 3):641-51. PubMed ID: 14769130
    [Abstract] [Full Text] [Related]

  • 18. Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.
    Luo M, Reyna S, Wang L, Yi Z, Carroll C, Dong LQ, Langlais P, Weintraub ST, Mandarino LJ.
    Endocrinology; 2005 Oct 01; 146(10):4410-6. PubMed ID: 16020478
    [Abstract] [Full Text] [Related]

  • 19. Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
    Gual P, Gonzalez T, Grémeaux T, Barres R, Le Marchand-Brustel Y, Tanti JF.
    J Biol Chem; 2003 Jul 18; 278(29):26550-7. PubMed ID: 12730242
    [Abstract] [Full Text] [Related]

  • 20. The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling.
    Myers MG, Grammer TC, Brooks J, Glasheen EM, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF.
    J Biol Chem; 1995 May 19; 270(20):11715-8. PubMed ID: 7744813
    [Abstract] [Full Text] [Related]

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