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205 related items for PubMed ID: 16574739

  • 21. Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
    Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G.
    Endocrinology; 2004 Jun; 145(6):2845-57. PubMed ID: 15001544
    [Abstract] [Full Text] [Related]

  • 22. Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).
    Li Y, Soos TJ, Li X, Wu J, Degennaro M, Sun X, Littman DR, Birnbaum MJ, Polakiewicz RD.
    J Biol Chem; 2004 Oct 29; 279(44):45304-7. PubMed ID: 15364919
    [Abstract] [Full Text] [Related]

  • 23. Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain.
    Waldron RT, Rozengurt E.
    J Biol Chem; 2003 Jan 03; 278(1):154-63. PubMed ID: 12407104
    [Abstract] [Full Text] [Related]

  • 24. Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo.
    Jiang G, Dallas-Yang Q, Biswas S, Li Z, Zhang BB.
    Biochem J; 2004 Jan 15; 377(Pt 2):339-46. PubMed ID: 14556646
    [Abstract] [Full Text] [Related]

  • 25. In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.
    Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ.
    J Biol Chem; 2002 Jul 19; 277(29):26530-9. PubMed ID: 12006586
    [Abstract] [Full Text] [Related]

  • 26. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases.
    Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J.
    J Biol Chem; 2003 Jul 04; 278(27):24944-50. PubMed ID: 12714600
    [Abstract] [Full Text] [Related]

  • 27. Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
    Liberman Z, Eldar-Finkelman H.
    J Biol Chem; 2005 Feb 11; 280(6):4422-8. PubMed ID: 15574412
    [Abstract] [Full Text] [Related]

  • 28. Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.
    Bloch-Damti A, Potashnik R, Gual P, Le Marchand-Brustel Y, Tanti JF, Rudich A, Bashan N.
    Diabetologia; 2006 Oct 11; 49(10):2463-73. PubMed ID: 16896943
    [Abstract] [Full Text] [Related]

  • 29. Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes.
    He J, Usui I, Ishizuka K, Kanatani Y, Hiratani K, Iwata M, Bukhari A, Haruta T, Sasaoka T, Kobayashi M.
    Mol Endocrinol; 2006 Jan 11; 20(1):114-24. PubMed ID: 16150868
    [Abstract] [Full Text] [Related]

  • 30. Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.
    Mothe I, Van Obberghen E.
    J Biol Chem; 1996 May 10; 271(19):11222-7. PubMed ID: 8626671
    [Abstract] [Full Text] [Related]

  • 31. Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein.
    Farhang-Fallah J, Yin X, Trentin G, Cheng AM, Rozakis-Adcock M.
    J Biol Chem; 2000 Dec 22; 275(51):40492-7. PubMed ID: 11018022
    [Abstract] [Full Text] [Related]

  • 32. The insulin receptor substrate (IRS)-1 pleckstrin homology domain functions in downstream signaling.
    Vainshtein I, Kovacina KS, Roth RA.
    J Biol Chem; 2001 Mar 16; 276(11):8073-8. PubMed ID: 11145958
    [Abstract] [Full Text] [Related]

  • 33. Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase.
    De Fea K, Roth RA.
    J Biol Chem; 1997 Dec 12; 272(50):31400-6. PubMed ID: 9395471
    [Abstract] [Full Text] [Related]

  • 34. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.
    Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA.
    J Biol Chem; 2003 Mar 07; 278(10):8199-211. PubMed ID: 12510059
    [Abstract] [Full Text] [Related]

  • 35. Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes.
    Zhou J, Wang Q, Ding Y, Zou MH.
    J Mol Endocrinol; 2015 Feb 07; 54(1):25-37. PubMed ID: 25381390
    [Abstract] [Full Text] [Related]

  • 36. Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue.
    Liberman Z, Plotkin B, Tennenbaum T, Eldar-Finkelman H.
    Am J Physiol Endocrinol Metab; 2008 Jun 07; 294(6):E1169-77. PubMed ID: 18430969
    [Abstract] [Full Text] [Related]

  • 37. Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling.
    Ahmed Z, Pillay TS.
    Biochem J; 2003 Apr 15; 371(Pt 2):405-12. PubMed ID: 12521378
    [Abstract] [Full Text] [Related]

  • 38. Protein kinase C inhibits insulin-induced Akt activation in vascular smooth muscle cells.
    Motley ED, Kabir SM, Eguchi K, Hicks AL, Gardner CD, Reynolds CM, Frank GD, Eguchi S.
    Cell Mol Biol (Noisy-le-grand); 2001 Sep 15; 47(6):1059-62. PubMed ID: 11785657
    [Abstract] [Full Text] [Related]

  • 39. Protein kinase C (PKC) beta modulates serine phosphorylation of insulin receptor substrate-1 (IRS-1)--effect of overexpression of PKCbeta on insulin signal transduction.
    Ishizuka T, Kajita K, Natsume Y, Kawai Y, Kanoh Y, Miura A, Ishizawa M, Uno Y, Morita H, Yasuda K.
    Endocr Res; 2004 May 15; 30(2):287-99. PubMed ID: 15473137
    [Abstract] [Full Text] [Related]

  • 40. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells.
    Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers MG, White MF, King GL.
    Diabetes; 1999 May 15; 48(5):1120-30. PubMed ID: 10331419
    [Abstract] [Full Text] [Related]

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