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294 related items for PubMed ID: 16579968

  • 1. The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells.
    Choi SM, Choi KO, Lee N, Oh M, Park H.
    Biochem Biophys Res Commun; 2006 May 19; 343(4):1002-8. PubMed ID: 16579968
    [Abstract] [Full Text] [Related]

  • 2. Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.
    Choi SM, Choi KO, Park YK, Cho H, Yang EG, Park H.
    J Biol Chem; 2006 Nov 10; 281(45):34056-63. PubMed ID: 16973622
    [Abstract] [Full Text] [Related]

  • 3. Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.
    Park YK, Ahn DR, Oh M, Lee T, Yang EG, Son M, Park H.
    Mol Pharmacol; 2008 Jul 10; 74(1):236-45. PubMed ID: 18426857
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger.
    Choi KO, Lee T, Lee N, Kim JH, Yang EG, Yoon JM, Kim JH, Lee TG, Park H.
    Mol Pharmacol; 2005 Dec 10; 68(6):1803-9. PubMed ID: 16155211
    [Abstract] [Full Text] [Related]

  • 5. Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.
    Lee HY, Lee T, Lee N, Yang EG, Lee C, Lee J, Moon EY, Ha J, Park H.
    Carcinogenesis; 2011 May 10; 32(5):703-12. PubMed ID: 21335603
    [Abstract] [Full Text] [Related]

  • 6. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.
    Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J.
    J Biol Chem; 2004 Mar 12; 279(11):9899-904. PubMed ID: 14701857
    [Abstract] [Full Text] [Related]

  • 7. Hypoxia-inducible factor 1 (HIF-1) pathway.
    Semenza GL.
    Sci STKE; 2007 Oct 09; 2007(407):cm8. PubMed ID: 17925579
    [Abstract] [Full Text] [Related]

  • 8. Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.
    Linke S, Stojkoski C, Kewley RJ, Booker GW, Whitelaw ML, Peet DJ.
    J Biol Chem; 2004 Apr 02; 279(14):14391-7. PubMed ID: 14734545
    [Abstract] [Full Text] [Related]

  • 9. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
    Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.
    EMBO J; 2003 Aug 15; 22(16):4082-90. PubMed ID: 12912907
    [Abstract] [Full Text] [Related]

  • 10. Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.
    Pereira T, Zheng X, Ruas JL, Tanimoto K, Poellinger L.
    J Biol Chem; 2003 Feb 28; 278(9):6816-23. PubMed ID: 12468553
    [Abstract] [Full Text] [Related]

  • 11. Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.
    Chan DA, Sutphin PD, Yen SE, Giaccia AJ.
    Mol Cell Biol; 2005 Aug 28; 25(15):6415-26. PubMed ID: 16024780
    [Abstract] [Full Text] [Related]

  • 12. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
    Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.
    Mol Cell; 2005 Feb 18; 17(4):503-12. PubMed ID: 15721254
    [Abstract] [Full Text] [Related]

  • 13. Activation of hypoxia-induced transcription in normoxia.
    Hägg M, Wennström S.
    Exp Cell Res; 2005 May 15; 306(1):180-91. PubMed ID: 15878343
    [Abstract] [Full Text] [Related]

  • 14. Chelation of cellular calcium modulates hypoxia-inducible gene expression through activation of hypoxia-inducible factor-1alpha.
    Berchner-Pfannschmidt U, Petrat F, Doege K, Trinidad B, Freitag P, Metzen E, de Groot H, Fandrey J.
    J Biol Chem; 2004 Oct 22; 279(43):44976-86. PubMed ID: 15322093
    [Abstract] [Full Text] [Related]

  • 15. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
    Stolze IP, Tian YM, Appelhoff RJ, Turley H, Wykoff CC, Gleadle JM, Ratcliffe PJ.
    J Biol Chem; 2004 Oct 08; 279(41):42719-25. PubMed ID: 15302861
    [Abstract] [Full Text] [Related]

  • 16. Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.
    Kageyama Y, Koshiji M, To KK, Tian YM, Ratcliffe PJ, Huang LE.
    FASEB J; 2004 Jun 08; 18(9):1028-30. PubMed ID: 15084514
    [Abstract] [Full Text] [Related]

  • 17. Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation.
    D'Angelo G, Duplan E, Vigne P, Frelin C.
    J Biol Chem; 2003 Apr 25; 278(17):15406-11. PubMed ID: 12586829
    [Abstract] [Full Text] [Related]

  • 18. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
    Flashman E, Davies SL, Yeoh KK, Schofield CJ.
    Biochem J; 2010 Mar 15; 427(1):135-42. PubMed ID: 20055761
    [Abstract] [Full Text] [Related]

  • 19. Oxygen-sensing under the influence of nitric oxide.
    Berchner-Pfannschmidt U, Tug S, Kirsch M, Fandrey J.
    Cell Signal; 2010 Mar 15; 22(3):349-56. PubMed ID: 19861159
    [Abstract] [Full Text] [Related]

  • 20. Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases.
    Metzen E, Zhou J, Jelkmann W, Fandrey J, Brüne B.
    Mol Biol Cell; 2003 Aug 15; 14(8):3470-81. PubMed ID: 12925778
    [Abstract] [Full Text] [Related]

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