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Journal Abstract Search

378 related items for PubMed ID: 16581193

  • 21. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.
    Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T.
    Nat Med; 1999 May; 5(5):560-4. PubMed ID: 10229234
    [Abstract] [Full Text] [Related]

  • 22. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers.
    Li F, Hayashi T, Jin G, Deguchi K, Nagotani S, Nagano I, Shoji M, Chan PH, Abe K.
    Brain Res; 2005 Jun 28; 1048(1-2):59-68. PubMed ID: 15921666
    [Abstract] [Full Text] [Related]

  • 23. Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease.
    Giovannini MG, Cerbai F, Bellucci A, Melani C, Grossi C, Bartolozzi C, Nosi D, Casamenti F.
    Neuroscience; 2008 May 15; 153(3):618-33. PubMed ID: 18406062
    [Abstract] [Full Text] [Related]

  • 24. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 15; 100(3):802-9. PubMed ID: 17156133
    [Abstract] [Full Text] [Related]

  • 25. Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
    Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S.
    J Neurosci Res; 2007 Jan 15; 85(1):153-65. PubMed ID: 17075903
    [Abstract] [Full Text] [Related]

  • 26. Amyloid beta-peptide 31-35-induced neuronal apoptosis is mediated by caspase-dependent pathways via cAMP-dependent protein kinase A activation.
    Zhao L, Qian ZM, Zhang C, Wing HY, Du F, Ya K.
    Aging Cell; 2008 Jan 15; 7(1):47-57. PubMed ID: 18005252
    [Abstract] [Full Text] [Related]

  • 27. Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt-Jakob disease.
    Paquet C, Bose A, Polivka M, Peoc'h K, Brouland JP, Keohane C, Hugon J, Gray F.
    J Neuropathol Exp Neurol; 2009 Feb 15; 68(2):190-8. PubMed ID: 19151623
    [Abstract] [Full Text] [Related]

  • 28. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.
    Refolo LM, Pappolla MA, LaFrancois J, Malester B, Schmidt SD, Thomas-Bryant T, Tint GS, Wang R, Mercken M, Petanceska SS, Duff KE.
    Neurobiol Dis; 2001 Oct 15; 8(5):890-9. PubMed ID: 11592856
    [Abstract] [Full Text] [Related]

  • 29. Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease.
    Michelsen KA, Korr H, Steinbusch HW, Schmitz C.
    Brain Res; 2010 Feb 26; 1316():139-44. PubMed ID: 20034479
    [Abstract] [Full Text] [Related]

  • 30. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.
    Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE.
    Brain; 2005 Jun 26; 128(Pt 6):1442-53. PubMed ID: 15817521
    [Abstract] [Full Text] [Related]

  • 31. Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.
    Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR, Shippy D, Tan J.
    Neuroscience; 2006 Nov 03; 142(4):941-52. PubMed ID: 16938404
    [Abstract] [Full Text] [Related]

  • 32. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
    Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA.
    Nature; 1998 Oct 15; 395(6703):698-702. PubMed ID: 9790190
    [Abstract] [Full Text] [Related]

  • 33. Early apoptotic and late necrotic components associated with altered Ca2+ homeostasis in a peptide-delivery model of polyglutamine-induced neuronal death.
    Suzuki M, Koike T.
    J Neurosci Res; 2005 May 15; 80(4):549-61. PubMed ID: 15825190
    [Abstract] [Full Text] [Related]

  • 34.
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  • 35. Localization of beta-secretase memapsin 2 in the brain of Alzheimer's patients and normal aged controls.
    Sun A, Koelsch G, Tang J, Bing G.
    Exp Neurol; 2002 May 15; 175(1):10-22. PubMed ID: 12009756
    [Abstract] [Full Text] [Related]

  • 36. BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration.
    Yoon SY, Choi JE, Yoon JH, Huh JW, Kim DH.
    Neurobiol Dis; 2006 May 15; 22(2):435-44. PubMed ID: 16480887
    [Abstract] [Full Text] [Related]

  • 37. Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.
    Wang PL, Niidome T, Akaike A, Kihara T, Sugimoto H.
    J Neurosci Res; 2009 Jul 15; 87(9):2105-14. PubMed ID: 19267423
    [Abstract] [Full Text] [Related]

  • 38. Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-beta-induced cell death.
    Leschik J, Welzel A, Weissmann C, Eckert A, Brandt R.
    J Neurochem; 2007 Jun 15; 101(5):1303-15. PubMed ID: 17298384
    [Abstract] [Full Text] [Related]

  • 39. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
    Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, Ma L, Shughrue P, Burchard J, Colussi D, Pietrak B, Kahana J, Beher D, Rosahl T, Shearman M, Hazuda D, Sachs AB, Koblan KS, Seabrook GR, Stone DJ.
    Proc Natl Acad Sci U S A; 2006 Nov 21; 103(47):17967-72. PubMed ID: 17098871
    [Abstract] [Full Text] [Related]

  • 40. S100B protects LAN-5 neuroblastoma cells against Abeta amyloid-induced neurotoxicity via RAGE engagement at low doses but increases Abeta amyloid neurotoxicity at high doses.
    Businaro R, Leone S, Fabrizi C, Sorci G, Donato R, Lauro GM, Fumagalli L.
    J Neurosci Res; 2006 Apr 21; 83(5):897-906. PubMed ID: 16477616
    [Abstract] [Full Text] [Related]

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