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256 related items for PubMed ID: 16595682

  • 1. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.
    Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y.
    J Biol Chem; 2006 May 26; 281(21):14776-86. PubMed ID: 16595682
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  • 2. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
    Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K.
    Am J Geriatr Psychiatry; 2013 May 26; 21(5):474-83. PubMed ID: 23570890
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  • 8. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.
    Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y.
    J Biol Chem; 2003 Jul 04; 278(27):24294-301. PubMed ID: 12707272
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  • 9. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
    Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ.
    Proc Natl Acad Sci U S A; 2000 Aug 01; 97(16):9299-304. PubMed ID: 10922078
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  • 10. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
    Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH.
    PLoS One; 2015 Aug 01; 10(12):e0144758. PubMed ID: 26678856
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  • 11. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.
    Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y.
    J Neurosci; 2005 Jan 12; 25(2):436-45. PubMed ID: 15647487
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  • 12. APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.
    Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J.
    Exp Cell Res; 2003 Jul 01; 287(1):1-9. PubMed ID: 12799176
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  • 13. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
    Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S.
    Acta Neuropathol Commun; 2015 Nov 04; 3():66. PubMed ID: 26531305
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  • 14. Mechanism of intramembrane cleavage of alcadeins by γ-secretase.
    Piao Y, Kimura A, Urano S, Saito Y, Taru H, Yamamoto T, Hata S, Suzuki T.
    PLoS One; 2013 Nov 04; 8(4):e62431. PubMed ID: 23658629
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  • 15. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
    Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.
    J Biol Chem; 2008 Jun 13; 283(24):16488-96. PubMed ID: 18430735
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  • 16. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
    Kume H, Maruyama K, Kametani F.
    Int J Mol Med; 2004 Jan 13; 13(1):121-5. PubMed ID: 14654982
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  • 20. Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.
    Wanngren J, Lara P, Ojemalm K, Maioli S, Moradi N, Chen L, Tjernberg LO, Lundkvist J, Nilsson I, Karlström H.
    FEBS Open Bio; 2014 Jan 13; 4():393-406. PubMed ID: 24918054
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