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358 related items for PubMed ID: 1660359

  • 1. Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium.
    Böhm M, Morano I, Pieske B, Rüegg JC, Wankerl M, Zimmermann R, Erdmann E.
    Circ Res; 1991 Mar; 68(3):689-701. PubMed ID: 1660359
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  • 2. Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations.
    von der Leyen H, Mende U, Meyer W, Neumann J, Nose M, Schmitz W, Scholz H, Starbatty J, Stein B, Wenzlaff H.
    Naunyn Schmiedebergs Arch Pharmacol; 1991 Jul; 344(1):90-100. PubMed ID: 1723153
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  • 3. EMD 53998 acts as Ca(2+)-sensitizer and phosphodiesterase III-inhibitor in human myocardium.
    Uhlmann R, Schwinger RH, Lues I, Erdmann E.
    Basic Res Cardiol; 1995 Jul; 90(5):365-71. PubMed ID: 8585857
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  • 4. Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart.
    Brunkhorst D, v der Leyen H, Meyer W, Nigbur R, Schmidt-Schumacher C, Scholz H.
    Naunyn Schmiedebergs Arch Pharmacol; 1989 May; 339(5):575-83. PubMed ID: 2549430
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  • 5. Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone.
    Fujino K, Sperelakis N, Solaro RJ.
    Circ Res; 1988 Nov; 63(5):911-22. PubMed ID: 2846200
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  • 7. Effects of the benzimidazole derivatives pimobendan and 2-(4-hydroxy-phenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6- pyridazinyl) benzimidazole . HCl on phosphodiesterase activity and force of contraction in guinea-pig hearts.
    Berger C, Meyer W, Scholz H, Starbatty J.
    Arzneimittelforschung; 1985 Nov; 35(11):1668-73. PubMed ID: 2418846
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  • 8. Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts.
    Bethke T, Eschenhagen T, Klimkiewicz A, Kohl C, von der Leyen H, Mehl H, Mende U, Meyer W, Neumann J, Rosswag S.
    Arzneimittelforschung; 1992 Apr; 42(4):437-45. PubMed ID: 1386515
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  • 9. The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers.
    Lues I, Beier N, Jonas R, Klockow M, Haeusler G.
    J Cardiovasc Pharmacol; 1993 Jun; 21(6):883-92. PubMed ID: 7687712
    [Abstract] [Full Text] [Related]

  • 10. The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments.
    Solaro RJ, Fujino K, Sperelakis N.
    J Cardiovasc Pharmacol; 1989 Jun; 14 Suppl 2():S7-12. PubMed ID: 2478795
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  • 11. Effect of inotropic stimulation on the negative force-frequency relationship in the failing human heart.
    Schwinger RH, Böhm M, Müller-Ehmsen J, Uhlmann R, Schmidt U, Stäblein A, Uberfuhr P, Kreuzer E, Reichart B, Eissner HJ.
    Circulation; 1993 Nov; 88(5 Pt 1):2267-76. PubMed ID: 8222121
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  • 12. Effects of isomazole on force of contraction and phosphodiesterase isoenzymes I-IV in nonfailing and failing human hearts.
    Bethke T, Klimkiewicz A, Kohl C, von der Leyen H, Mehl H, Mende U, Meyer W, Neumann J, Schmitz W, Scholz H.
    J Cardiovasc Pharmacol; 1991 Sep; 18(3):386-97. PubMed ID: 1720839
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  • 13. Increase in force of contraction by activation of the Na+/Ca(2+)-exchanger in human myocardium.
    Müller-Ehmsen J, Frank K, Brixius K, Schwinger RH.
    Br J Clin Pharmacol; 1997 Apr; 43(4):399-405. PubMed ID: 9146852
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  • 14. Enhancement of the effectiveness of milrinone to increase force of contraction by stimulation of cardiac beta-adrenoceptors in the failing human heart.
    Böhm M, Diet F, Kemkes B, Erdmann E.
    Klin Wochenschr; 1988 Oct 03; 66(19):957-62. PubMed ID: 2846949
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  • 15. Reduction of beta-adrenoceptor density and evaluation of positive inotropic responses in isolated, diseased human myocardium.
    Böhm M, Beuckelmann D, Brown L, Feiler G, Lorenz B, Näbauer M, Kemkes B, Erdmann E.
    Eur Heart J; 1988 Aug 03; 9(8):844-52. PubMed ID: 2460351
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  • 16. Evidence for a sustained effectiveness of sodium-channel activators in failing human myocardium.
    Schwinger RH, Böhm M, Mittmann C, La Rosée K, Erdmann E.
    J Mol Cell Cardiol; 1991 Apr 03; 23(4):461-71. PubMed ID: 1658340
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  • 19. Reduced alpha 1- and beta 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure.
    Steinfath M, Danielsen W, von der Leyen H, Mende U, Meyer W, Neumann J, Nose M, Reich T, Schmitz W, Scholz H.
    Br J Pharmacol; 1992 Feb 03; 105(2):463-9. PubMed ID: 1348446
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  • 20. Different mechanisms involved in the positive inotropic effects of benzimidazole derivative UD-CG 115 BS (pimobendan) and its demethylated metabolite UD-CG 212 Cl in canine ventricular myocardium.
    Endoh M, Shibasaki T, Satoh H, Norota I, Ishihata A.
    J Cardiovasc Pharmacol; 1991 Mar 03; 17(3):365-75. PubMed ID: 1711596
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