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122 related items for PubMed ID: 1663578

  • 1. Signal transduction by the human thyrotropin receptor: studies on the role of individual amino acid residues in the carboxyl terminal region of the third cytoplasmic loop.
    Chazenbalk GD, Nagayama Y, Wadsworth H, Russo D, Rapoport B.
    Mol Endocrinol; 1991 Oct; 5(10):1523-6. PubMed ID: 1663578
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  • 2. Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction.
    Nagayama Y, Rapoport B.
    Endocrinology; 1992 Aug; 131(2):548-52. PubMed ID: 1322272
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  • 3. Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive, TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3',5'-cyclic adenosine monophosphate signal generation.
    Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD.
    Mol Endocrinol; 1993 Aug; 7(8):1009-20. PubMed ID: 7901757
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  • 4. Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.
    Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD.
    J Biol Chem; 1992 Dec 05; 267(34):24153-6. PubMed ID: 1332945
    [Abstract] [Full Text] [Related]

  • 5. The middle portion in the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation.
    Kosugi S, Kohn LD, Akamizu T, Mori T.
    Mol Endocrinol; 1994 Apr 05; 8(4):498-509. PubMed ID: 7914349
    [Abstract] [Full Text] [Related]

  • 6. Site-directed mutagenesis of amino acids 33-44 of the common alpha-subunit reveals different structural requirements for heterodimer expression among the glycoprotein hormones and suggests that cyclic adenosine 3',5'-monophosphate production and growth promotion are potentially dissociable functions of human thyrotropin.
    Grossmann M, Szkudlinski MW, Dias JA, Xia H, Wong R, Puett D, Weintraub BD.
    Mol Endocrinol; 1996 Jun 05; 10(6):769-79. PubMed ID: 8776737
    [Abstract] [Full Text] [Related]

  • 7. Functional analysis of the cytoplasmic domains of the human thyrotropin receptor by site-directed mutagenesis.
    Chazenbalk GD, Nagayama Y, Russo D, Wadsworth HL, Rapoport B.
    J Biol Chem; 1990 Dec 05; 265(34):20970-5. PubMed ID: 2250002
    [Abstract] [Full Text] [Related]

  • 8. The amino-terminal half of the cytoplasmic tail of the thyrotropin receptor is essential for full activities of receptor function.
    Kosugi S, Mori T.
    Biochem Biophys Res Commun; 1994 Apr 15; 200(1):401-7. PubMed ID: 8166712
    [Abstract] [Full Text] [Related]

  • 9. Studies on the role of amino acids 38-45 in the expression of a functional thyrotropin receptor.
    Wadsworth HL, Russo D, Nagayama Y, Chazenbalk GD, Rapoport B.
    Mol Endocrinol; 1992 Mar 15; 6(3):394-8. PubMed ID: 1584215
    [Abstract] [Full Text] [Related]

  • 10. Further studies of amino acids (268-304) in thyrotropin (TSH)--lutropin/chorionic gonadotropin (LH/CG) receptor chimeras: cysteine-301 is important in TSH binding and receptor tertiary structure.
    Akamizu T, Inoue D, Kosugi S, Kohn LD, Mori T.
    Thyroid; 1994 Mar 15; 4(1):43-8. PubMed ID: 8054860
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  • 13. Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors.
    Kosugi S, Ban T, Akamizu T, Kohn LD.
    Mol Endocrinol; 1992 Feb 15; 6(2):168-80. PubMed ID: 1349156
    [Abstract] [Full Text] [Related]

  • 14. Both the 5' and 3' noncoding regions of the thyrotropin receptor messenger ribonucleic acid influence the level of receptor protein expression in transfected mamalian cells.
    Kakinuma A, Chazenbalk G, Filetti S, McLachlan SM, Rapoport B.
    Endocrinology; 1996 Jul 15; 137(7):2664-9. PubMed ID: 8770884
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  • 16. Thyroid stimulatory autoantibodies in different patients with autoimmune thyroid disease do not all recognize the same components of the human thyrotropin receptor: selective role of receptor amino acids Ser25-Glu30.
    Nagayama Y, Rapoport B.
    J Clin Endocrinol Metab; 1992 Dec 15; 75(6):1425-30. PubMed ID: 1361193
    [Abstract] [Full Text] [Related]

  • 17. The functional significance of the second extracellular loop of thyrotropin receptor in thyrotropin- and thyroid stimulating antibody-dependent signal transduction.
    Kaneshige M, Haraguchi K, Endo T, Anzai E, Onaya T.
    Horm Metab Res; 1995 Jun 15; 27(6):267-71. PubMed ID: 7557836
    [Abstract] [Full Text] [Related]

  • 18. Chimeric studies of the extracellular domain of the rat thyrotropin (TSH) receptor: amino acids (268-304) in the TSH receptor are involved in ligand high affinity binding, but not in TSH receptor-specific signal transduction.
    Akamizu T, Inoue D, Kosugi S, Ban T, Kohn LD, Imura H, Mori T.
    Endocr J; 1993 Jun 15; 40(3):363-72. PubMed ID: 7920890
    [Abstract] [Full Text] [Related]

  • 19. Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist.
    Vlaeminck-Guillem V, Ho SC, Rodien P, Vassart G, Costagliola S.
    Mol Endocrinol; 2002 Apr 15; 16(4):736-46. PubMed ID: 11923470
    [Abstract] [Full Text] [Related]

  • 20. The thyrotropin (TSH) receptor transmembrane domain mutation (Pro556-Leu) in the hypothyroid hyt/hyt mouse results in plasma membrane targeting but defective TSH binding.
    Gu WX, Du GG, Kopp P, Rentoumis A, Albanese C, Kohn LD, Madison LD, Jameson JL.
    Endocrinology; 1995 Jul 15; 136(7):3146-53. PubMed ID: 7789342
    [Abstract] [Full Text] [Related]

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