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Journal Abstract Search

206 related items for PubMed ID: 16640339

  • 1. Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent Anti-HIV-1 activity.
    Imamura S, Ichikawa T, Nishikawa Y, Kanzaki N, Takashima K, Niwa S, Iizawa Y, Baba M, Sugihara Y.
    J Med Chem; 2006 May 04; 49(9):2784-93. PubMed ID: 16640339
    [Abstract] [Full Text] [Related]

  • 2. CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological evaluation of piperidine-4-carboxamide derivatives.
    Imamura S, Nishikawa Y, Ichikawa T, Hattori T, Matsushita Y, Hashiguchi S, Kanzaki N, Iizawa Y, Baba M, Sugihara Y.
    Bioorg Med Chem; 2005 Jan 17; 13(2):397-416. PubMed ID: 15598561
    [Abstract] [Full Text] [Related]

  • 3. Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety.
    Seto M, Aikawa K, Miyamoto N, Aramaki Y, Kanzaki N, Takashima K, Kuze Y, Iizawa Y, Baba M, Shiraishi M.
    J Med Chem; 2006 Mar 23; 49(6):2037-48. PubMed ID: 16539392
    [Abstract] [Full Text] [Related]

  • 4. CCR5 antagonists as anti-HIV-1 agents. Part 2: Synthesis and biological evaluation of N-[3-(4-benzylpiperidin-1-yl)propyl]-N,N'-diphenylureas.
    Imamura S, Kurasawa O, Nara Y, Ichikawa T, Nishikawa Y, Iida T, Hashiguchi S, Kanzaki N, Iizawa Y, Baba M, Sugihara Y.
    Bioorg Med Chem; 2004 May 01; 12(9):2295-306. PubMed ID: 15080927
    [Abstract] [Full Text] [Related]

  • 5. The discovery of tropane-derived CCR5 receptor antagonists.
    Armour DR, de Groot MJ, Price DA, Stammen BL, Wood A, Perros M, Burt C.
    Chem Biol Drug Des; 2006 Apr 01; 67(4):305-8. PubMed ID: 16629828
    [Abstract] [Full Text] [Related]

  • 6. Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
    Shankaran K, Donnelly KL, Shah SK, Caldwell CG, Chen P, Finke PE, Oates B, MacCoss M, Mills SG, DeMartino JA, Gould SL, Malkowitz L, Siciliano SJ, Springer MS, Kwei G, Carella A, Carver G, Danzeisen R, Hazuda D, Holmes K, Kessler J, Lineberger J, Miller MD, Emini EA, Schleif WA.
    Bioorg Med Chem Lett; 2004 Jul 05; 14(13):3589-93. PubMed ID: 15177481
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
    Shah SK, Chen N, Guthikonda RN, Mills SG, Malkowitz L, Springer MS, Gould SL, Demartino JA, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller M, Emini EA, MacCoss M.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):977-82. PubMed ID: 15686896
    [Abstract] [Full Text] [Related]

  • 8. [2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists: derivatizations at the N-terminal of the piperidine ring.
    Duan M, Aquino C, Ferris R, Kazmierski WM, Kenakin T, Koble C, Wheelan P, Watson C, Youngman M.
    Bioorg Med Chem Lett; 2009 Mar 15; 19(6):1610-3. PubMed ID: 19233649
    [Abstract] [Full Text] [Related]

  • 9. CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives.
    Lu SF, Chen B, Davey D, Dunning L, Jaroch S, May K, Onuffer J, Phillips G, Subramanyam B, Tseng JL, Wei RG, Wei M, Ye B.
    Bioorg Med Chem Lett; 2007 Apr 01; 17(7):1883-7. PubMed ID: 17314043
    [Abstract] [Full Text] [Related]

  • 10. Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
    Shen DM, Shu M, Mills SG, Chapman KT, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Kwei GY, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller MD, Emini EA.
    Bioorg Med Chem Lett; 2004 Feb 23; 14(4):935-9. PubMed ID: 15012997
    [Abstract] [Full Text] [Related]

  • 11. 1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV. Part 1.
    Barber CG, Blakemore DC, Chiva JY, Eastwood RL, Middleton DS, Paradowski KA.
    Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1075-9. PubMed ID: 19171484
    [Abstract] [Full Text] [Related]

  • 12. Anti-HIV-1 entry optimization of novel imidazopiperidine-tropane CCR5 antagonists.
    Ernst J, Dahl R, Lum C, Sebo L, Urban J, Miller SG, Lundström J.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1498-501. PubMed ID: 18194864
    [Abstract] [Full Text] [Related]

  • 13. Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
    Shen DM, Shu M, Willoughby CA, Shah S, Lynch CL, Hale JJ, Mills SG, Chapman KT, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Lyons K, Pivnichny JV, Kwei GY, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller MD, Emini EA.
    Bioorg Med Chem Lett; 2004 Feb 23; 14(4):941-5. PubMed ID: 15012998
    [Abstract] [Full Text] [Related]

  • 14. Orally active CCR5 antagonists as anti-HIV-1 agents. Part 3: Synthesis and biological activities of 1-benzazepine derivatives containing a sulfoxide moiety.
    Seto M, Miyamoto N, Aikawa K, Aramaki Y, Kanzaki N, Iizawa Y, Baba M, Shiraishi M.
    Bioorg Med Chem; 2005 Jan 17; 13(2):363-86. PubMed ID: 15598559
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis, and biological evaluation of novel piperidine-4-carboxamide derivatives as potent CCR5 inhibitors.
    Hu S, Gu Q, Wang Z, Weng Z, Cai Y, Dong X, Hu Y, Liu T, Xie X.
    Eur J Med Chem; 2014 Jan 17; 71():259-66. PubMed ID: 24316669
    [Abstract] [Full Text] [Related]

  • 16. Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
    Shu M, Loebach JL, Parker KA, Mills SG, Chapman KT, Shen DM, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Salvo JD, Lyons K, Pivnichny JV, Kwei GY, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller MD, Emini EA.
    Bioorg Med Chem Lett; 2004 Feb 23; 14(4):947-52. PubMed ID: 15012999
    [Abstract] [Full Text] [Related]

  • 17. TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans.
    Baba M, Takashima K, Miyake H, Kanzaki N, Teshima K, Wang X, Shiraishi M, Iizawa Y.
    Antimicrob Agents Chemother; 2005 Nov 23; 49(11):4584-91. PubMed ID: 16251299
    [Abstract] [Full Text] [Related]

  • 18. Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro.
    Maeda K, Nakata H, Koh Y, Miyakawa T, Ogata H, Takaoka Y, Shibayama S, Sagawa K, Fukushima D, Moravek J, Koyanagi Y, Mitsuya H.
    J Virol; 2004 Aug 23; 78(16):8654-62. PubMed ID: 15280474
    [Abstract] [Full Text] [Related]

  • 19. Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents.
    Li B, Jones ED, Zhou E, Chen L, Baylis DC, Yu S, Wang M, He X, Coates JA, Rhodes DI, Pei G, Deadman JJ, Xie X, Ma D.
    Bioorg Med Chem Lett; 2010 Sep 01; 20(17):5334-6. PubMed ID: 20674358
    [Abstract] [Full Text] [Related]

  • 20. Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication.
    Skerlj R, Bridger G, Zhou Y, Bourque E, McEachern E, Langille J, Harwig C, Veale D, Yang W, Li T, Zhu Y, Bey M, Baird I, Sartori M, Metz M, Mosi R, Nelson K, Bodart V, Wong R, Fricker S, Mac Farland R, Huskens D, Schols D.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):6950-4. PubMed ID: 22033460
    [Abstract] [Full Text] [Related]

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