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210 related items for PubMed ID: 16648369

  • 1. The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat.
    Natesan S, Svensson KA, Reckless GE, Nobrega JN, Barlow KB, Johansson AM, Kapur S.
    J Pharmacol Exp Ther; 2006 Aug; 318(2):810-8. PubMed ID: 16648369
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  • 2. Effects of the dopamine stabilizers (S)-(-)-OSU6162 and ACR16 on prolactin secretion in drug-naive and monoamine-depleted rats.
    Rung JP, Rung E, Johansson AM, Svensson K, Carlsson A, Carlsson ML.
    Naunyn Schmiedebergs Arch Pharmacol; 2011 Jul; 384(1):39-45. PubMed ID: 21533991
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  • 3. Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models.
    Natesan S, Reckless GE, Nobrega JN, Fletcher PJ, Kapur S.
    Neuropsychopharmacology; 2006 Sep; 31(9):1854-63. PubMed ID: 16319908
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  • 4. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties.
    Dyhring T, Nielsen EØ, Sonesson C, Pettersson F, Karlsson J, Svensson P, Christophersen P, Waters N.
    Eur J Pharmacol; 2010 Feb 25; 628(1-3):19-26. PubMed ID: 19919834
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  • 5. Effects of (-)-OSU6162 and ACR16 on motor activity in rats, indicating a unique mechanism of dopaminergic stabilization.
    Rung JP, Rung E, Helgeson L, Johansson AM, Svensson K, Carlsson A, Carlsson ML.
    J Neural Transm (Vienna); 2008 Jun 25; 115(6):899-908. PubMed ID: 18351286
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  • 6. Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models.
    Natesan S, Reckless GE, Barlow KB, Nobrega JN, Kapur S.
    Int J Neuropsychopharmacol; 2011 Oct 25; 14(9):1165-78. PubMed ID: 21087552
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  • 8. In vivo occupancy of dopamine D2 receptors by antipsychotic drugs and novel compounds in the mouse striatum and olfactory tubercles.
    Assié MB, Dominguez H, Consul-Denjean N, Newman-Tancredi A.
    Naunyn Schmiedebergs Arch Pharmacol; 2006 Sep 25; 373(6):441-50. PubMed ID: 16947046
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  • 9. Analysis of the actions of the novel dopamine receptor-directed compounds (S)-OSU6162 and ACR16 at the D2 dopamine receptor.
    Kara E, Lin H, Svensson K, Johansson AM, Strange PG.
    Br J Pharmacol; 2010 Nov 25; 161(6):1343-50. PubMed ID: 20804495
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  • 10. Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action.
    Kapur S, McClelland RA, VanderSpek SC, Wadenberg ML, Baker G, Nobrega J, Zipursky RB, Seeman P.
    Neuroreport; 2002 May 07; 13(6):831-5. PubMed ID: 11997696
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  • 12. The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats.
    Rung JP, Carlsson A, Markinhuhta KR, Carlsson ML.
    Prog Neuropsychopharmacol Biol Psychiatry; 2005 Jun 07; 29(5):833-9. PubMed ID: 15913873
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  • 13. 2-Bromoterguride-a potential atypical antipsychotic drug without metabolic effects in rats.
    Franke RT, Tarland E, Fink H, Pertz HH, Brosda J.
    Psychopharmacology (Berl); 2016 Aug 07; 233(15-16):3041-50. PubMed ID: 27317020
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  • 15. Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine.
    Natesan S, Reckless GE, Barlow KB, Nobrega JN, Kapur S.
    Schizophr Res; 2008 Oct 07; 105(1-3):224-35. PubMed ID: 18710798
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  • 16. Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).
    Pettersson F, Pontén H, Waters N, Waters S, Sonesson C.
    J Med Chem; 2010 Mar 25; 53(6):2510-20. PubMed ID: 20155917
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