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210 related items for PubMed ID: 16648369

  • 1. The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat.
    Natesan S, Svensson KA, Reckless GE, Nobrega JN, Barlow KB, Johansson AM, Kapur S.
    J Pharmacol Exp Ther; 2006 Aug; 318(2):810-8. PubMed ID: 16648369
    [Abstract] [Full Text] [Related]

  • 2. Effects of the dopamine stabilizers (S)-(-)-OSU6162 and ACR16 on prolactin secretion in drug-naive and monoamine-depleted rats.
    Rung JP, Rung E, Johansson AM, Svensson K, Carlsson A, Carlsson ML.
    Naunyn Schmiedebergs Arch Pharmacol; 2011 Jul; 384(1):39-45. PubMed ID: 21533991
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  • 3. Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models.
    Natesan S, Reckless GE, Nobrega JN, Fletcher PJ, Kapur S.
    Neuropsychopharmacology; 2006 Sep; 31(9):1854-63. PubMed ID: 16319908
    [Abstract] [Full Text] [Related]

  • 4. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties.
    Dyhring T, Nielsen EØ, Sonesson C, Pettersson F, Karlsson J, Svensson P, Christophersen P, Waters N.
    Eur J Pharmacol; 2010 Feb 25; 628(1-3):19-26. PubMed ID: 19919834
    [Abstract] [Full Text] [Related]

  • 5. Effects of (-)-OSU6162 and ACR16 on motor activity in rats, indicating a unique mechanism of dopaminergic stabilization.
    Rung JP, Rung E, Helgeson L, Johansson AM, Svensson K, Carlsson A, Carlsson ML.
    J Neural Transm (Vienna); 2008 Jun 25; 115(6):899-908. PubMed ID: 18351286
    [Abstract] [Full Text] [Related]

  • 6. Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models.
    Natesan S, Reckless GE, Barlow KB, Nobrega JN, Kapur S.
    Int J Neuropsychopharmacol; 2011 Oct 25; 14(9):1165-78. PubMed ID: 21087552
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  • 10. Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action.
    Kapur S, McClelland RA, VanderSpek SC, Wadenberg ML, Baker G, Nobrega J, Zipursky RB, Seeman P.
    Neuroreport; 2002 May 07; 13(6):831-5. PubMed ID: 11997696
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  • 12. The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats.
    Rung JP, Carlsson A, Markinhuhta KR, Carlsson ML.
    Prog Neuropsychopharmacol Biol Psychiatry; 2005 Jun 07; 29(5):833-9. PubMed ID: 15913873
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  • 13. 2-Bromoterguride-a potential atypical antipsychotic drug without metabolic effects in rats.
    Franke RT, Tarland E, Fink H, Pertz HH, Brosda J.
    Psychopharmacology (Berl); 2016 Aug 07; 233(15-16):3041-50. PubMed ID: 27317020
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  • 14. The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects.
    Tolboom N, Berendse HW, Leysen JE, Yaqub M, van Berckel BN, Schuit RC, Ponsen MM, Bakker E, Hoetjes NJ, Windhorst AD, Carlsson ML, Lammertsma AA, Carlsson A.
    Neuropsychopharmacology; 2015 Jan 07; 40(2):472-9. PubMed ID: 25248987
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  • 15. Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine.
    Natesan S, Reckless GE, Barlow KB, Nobrega JN, Kapur S.
    Schizophr Res; 2008 Oct 07; 105(1-3):224-35. PubMed ID: 18710798
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  • 16. Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).
    Pettersson F, Pontén H, Waters N, Waters S, Sonesson C.
    J Med Chem; 2010 Mar 25; 53(6):2510-20. PubMed ID: 20155917
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  • 17. Effects of l-stepholidine on forebrain Fos expression: comparison with clozapine and haloperidol.
    Mo YQ, Jin XL, Chen YT, Jin GZ, Shi WX.
    Neuropsychopharmacology; 2005 Feb 25; 30(2):261-7. PubMed ID: 15578005
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  • 18. Induction of c-fos mRNA in rat medial prefrontal cortex by antipsychotic drugs: role of dopamine D2 and D3 receptors.
    Merchant KM, Figur LM, Evans DL.
    Cereb Cortex; 1996 Feb 25; 6(4):561-70. PubMed ID: 8670682
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  • 19. Contrasting loxapine to its isomer isoloxapine--the critical role of in vivo D2 blockade in determining atypicality.
    Natesan S, Vanderspek S, Nobrega JN, McClelland RA, Kapur S.
    Schizophr Res; 2005 Sep 15; 77(2-3):189-99. PubMed ID: 15925489
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  • 20. Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery.
    Samaha AN, Reckless GE, Seeman P, Diwan M, Nobrega JN, Kapur S.
    Biol Psychiatry; 2008 Jul 15; 64(2):145-52. PubMed ID: 18295747
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