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514 related items for PubMed ID: 16650965

  • 1. Asn229 in the third helix of VPAC1 receptor is essential for receptor activation but not for receptor phosphorylation and internalization: comparison with Asn216 in VPAC2 receptor.
    Nachtergael I, Gaspard N, Langlet C, Robberecht P, Langer I.
    Cell Signal; 2006 Dec; 18(12):2121-30. PubMed ID: 16650965
    [Abstract] [Full Text] [Related]

  • 2. Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptor.
    Langer I, Langlet C, Robberecht P.
    J Mol Endocrinol; 2005 Apr; 34(2):405-14. PubMed ID: 15821106
    [Abstract] [Full Text] [Related]

  • 3. Ac His1 [D-Phe2, K15, R16, L27] VIP (3-7)/GRF (8-27)--a VPAC1 receptor antagonist--is an inverse agonist on two constitutively active truncated VPAC1 receptors.
    Vertongen P, Langlet C, Langer I, Gaspard N, Robberecht P.
    Peptides; 2004 Nov; 25(11):1943-9. PubMed ID: 15501526
    [Abstract] [Full Text] [Related]

  • 4. Serine 447 in the carboxyl tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor.
    Marie JC, Rouyer-Fessard C, Couvineau A, Nicole P, Devaud H, El Benna J, Laburthe M.
    Mol Pharmacol; 2003 Dec; 64(6):1565-74. PubMed ID: 14645688
    [Abstract] [Full Text] [Related]

  • 5. Pharmacological properties of Chinese hamster ovary cells coexpressing two vasoactive intestinal peptide receptors (hVPAC1 and hVPAC2).
    Langer I, Gaspard N, Robberecht P.
    Br J Pharmacol; 2006 Aug; 148(8):1051-9. PubMed ID: 16783404
    [Abstract] [Full Text] [Related]

  • 6. Mutations in the carboxy-terminus of the third intracellular loop of the human recombinant VPAC1 receptor impair VIP-stimulated [Ca2+]i increase but not adenylate cyclase stimulation.
    Langer I, Robberecht P.
    Cell Signal; 2005 Jan; 17(1):17-24. PubMed ID: 15451021
    [Abstract] [Full Text] [Related]

  • 7. Mutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC(2): role of basic residues in the second transmembrane helix.
    Vertongen P, Solano RM, Perret J, Langer I, Robberecht P, Waelbroeck M.
    Br J Pharmacol; 2001 Aug; 133(8):1249-54. PubMed ID: 11498510
    [Abstract] [Full Text] [Related]

  • 8. Characterization of a novel VPAC(1) selective agonist and identification of the receptor domains implicated in the carboxyl-terminal peptide recognition.
    Van Rampelbergh J, Juarranz MG, Perret J, Bondue A, Solano RM, Delporte C, De Neef P, Robberecht P, Waelbroeck M.
    Br J Pharmacol; 2000 Jun; 130(4):819-26. PubMed ID: 10864888
    [Abstract] [Full Text] [Related]

  • 9. Mutation of the phosphorylatable residue Thr429 in Glu of the human VPAC1 led to a constitutively desensitized receptor.
    Langlet C, Nachtergael I, Robberecht P, Langer I.
    Peptides; 2006 Jul; 27(7):1865-70. PubMed ID: 16554109
    [Abstract] [Full Text] [Related]

  • 10. Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activation.
    Chugunov AO, Simms J, Poyner DR, Dehouck Y, Rooman M, Gilis D, Langer I.
    Mol Pharmacol; 2010 Sep; 78(3):394-401. PubMed ID: 20573782
    [Abstract] [Full Text] [Related]

  • 11. Molecular mechanisms involved in vasoactive intestinal peptide receptor activation and regulation: current knowledge, similarities to and differences from the A family of G-protein-coupled receptors.
    Langer I, Robberecht P.
    Biochem Soc Trans; 2007 Aug; 35(Pt 4):724-8. PubMed ID: 17635134
    [Abstract] [Full Text] [Related]

  • 12. Aspartate 196 in the first extracellular loop of the human VIP1 receptor is essential for VIP binding and VIP-stimulated cAMP production.
    Du K, Nicole P, Couvineau A, Laburthe M.
    Biochem Biophys Res Commun; 1997 Jan 13; 230(2):289-92. PubMed ID: 9016768
    [Abstract] [Full Text] [Related]

  • 13. Two tyrosine residues in the first transmembrane helix of the human vasoactive intestinal peptide receptors play a role in supporting the active conformation.
    Perret J, Vertongen P, Solano RM, Langer I, Cnudde J, Robberecht P, Waelbroeck M.
    Br J Pharmacol; 2002 Aug 13; 136(7):1042-8. PubMed ID: 12145104
    [Abstract] [Full Text] [Related]

  • 14. Internalization of the gastrin-releasing peptide receptor is mediated by both phospholipase C-dependent and -independent processes.
    Benya RV, Akeson M, Mrozinski J, Jensen RT, Battey JF.
    Mol Pharmacol; 1994 Sep 13; 46(3):495-501. PubMed ID: 7935330
    [Abstract] [Full Text] [Related]

  • 15. Cross-chimeric analysis of selectivity of secretin and VPAC(1) receptor activation.
    Park CG, Ganguli SC, Pinon DI, Hadac EM, Miller LJ.
    J Pharmacol Exp Ther; 2000 Nov 13; 295(2):682-8. PubMed ID: 11046106
    [Abstract] [Full Text] [Related]

  • 16. Elucidation of the vasoactive intestinal peptide pharmacophore for VPAC(2) receptors in human and rat and comparison to the pharmacophore for VPAC(1) receptors.
    Igarashi H, Ito T, Pradhan TK, Mantey SA, Hou W, Coy DH, Jensen RT.
    J Pharmacol Exp Ther; 2002 Nov 13; 303(2):445-60. PubMed ID: 12388623
    [Abstract] [Full Text] [Related]

  • 17. Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding.
    Nicole P, Maoret JJ, Couvineau A, Momany FA, Laburthe M.
    Biochem Biophys Res Commun; 2000 Sep 24; 276(2):654-9. PubMed ID: 11027527
    [Abstract] [Full Text] [Related]

  • 18. A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology.
    Dickson L, Aramori I, McCulloch J, Sharkey J, Finlayson K.
    Neuropharmacology; 2006 Nov 24; 51(6):1086-98. PubMed ID: 16930633
    [Abstract] [Full Text] [Related]

  • 19. Comparative efficacy of VIP and analogs on activation and internalization of the recombinant VPAC2 receptor expressed in CHO cells.
    Langlet C, Gaspard N, Nachtergael I, Robberecht P, Langer I.
    Peptides; 2004 Dec 24; 25(12):2079-86. PubMed ID: 15572195
    [Abstract] [Full Text] [Related]

  • 20. Evidence for a direct interaction between the Thr11 residue of vasoactive intestinal polypeptide and Tyr184 located in the first extracellular loop of the VPAC2 receptor.
    Nachtergael I, Vertongen P, Langer I, Perret J, Robberecht P, Waelbroeck M.
    Biochem J; 2003 Mar 15; 370(Pt 3):1003-9. PubMed ID: 12475394
    [Abstract] [Full Text] [Related]


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