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Journal Abstract Search

216 related items for PubMed ID: 16681368

  • 1. Structure-guided design of peptide-based tryptase inhibitors.
    McGrath ME, Sprengeler PA, Hirschbein B, Somoza JR, Lehoux I, Janc JW, Gjerstad E, Graupe M, Estiarte A, Venkataramani C, Liu Y, Yee R, Ho JD, Green MJ, Lee CS, Liu L, Tai V, Spencer J, Sperandio D, Katz BA.
    Biochemistry; 2006 May 16; 45(19):5964-73. PubMed ID: 16681368
    [Abstract] [Full Text] [Related]

  • 2. Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
    Sutton JC, Bolton SA, Davis ME, Hartl KS, Jacobson B, Mathur A, Ogletree ML, Slusarchyk WA, Zahler R, Seiler SM, Bisacchi GS.
    Bioorg Med Chem Lett; 2004 May 03; 14(9):2233-9. PubMed ID: 15081015
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor.
    Scarpi D, McBride JD, Leatherbarrow RJ.
    Bioorg Med Chem; 2004 Dec 01; 12(23):6045-52. PubMed ID: 15519150
    [Abstract] [Full Text] [Related]

  • 4. Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.
    Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM, Spraggon G, Bursulaya B, Pacoma R, Shipway A, Schumacher AM, Danahay H, Harris JL.
    Bioorg Med Chem Lett; 2008 Nov 15; 18(22):5895-9. PubMed ID: 18752942
    [Abstract] [Full Text] [Related]

  • 5. Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation.
    Hopkins C, Neuenschwander K, Scotese A, Jackson S, Nieduzak T, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Maignan S, Mathieu M.
    Bioorg Med Chem Lett; 2004 Oct 04; 14(19):4819-23. PubMed ID: 15341931
    [Abstract] [Full Text] [Related]

  • 6. Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.
    Bisacchi GS, Slusarchyk WA, Bolton SA, Hartl KS, Jacobs G, Mathur A, Meng W, Ogletree ML, Pi Z, Sutton JC, Treuner U, Zahler R, Zhao G, Seiler SM.
    Bioorg Med Chem Lett; 2004 May 03; 14(9):2227-31. PubMed ID: 15081014
    [Abstract] [Full Text] [Related]

  • 7. 1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase.
    Wong T, Groutas CS, Mohan S, Lai Z, Alliston KR, Vu N, Schechter NM, Groutas WC.
    Arch Biochem Biophys; 2005 Apr 01; 436(1):1-7. PubMed ID: 15752703
    [Abstract] [Full Text] [Related]

  • 8. Dimethylthiazolidine carboxylic acid as a rigid p3 unit in inhibitors of serine proteases: application to two targets.
    Kawai SH, Aubry N, Duceppe JS, Llinàs-Brunet M, LaPlante SR.
    Chem Biol Drug Des; 2009 Nov 01; 74(5):517-22. PubMed ID: 19780760
    [Abstract] [Full Text] [Related]

  • 9. Design of novel, potent, and selective human beta-tryptase inhibitors based on alpha-keto-[1,2,4]-oxadiazoles.
    Lee CS, Liu W, Sprengeler PA, Somoza JR, Janc JW, Sperandio D, Spencer JR, Green MJ, McGrath ME.
    Bioorg Med Chem Lett; 2006 Aug 01; 16(15):4036-40. PubMed ID: 16714109
    [Abstract] [Full Text] [Related]

  • 10. Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination.
    Shiraishi T, Kadono S, Haramura M, Kodama H, Ono Y, Iikura H, Esaki T, Koga T, Hattori K, Watanabe Y, Sakamoto A, Yoshihashi K, Kitazawa T, Esaki K, Ohta M, Sato H, Kozono T.
    Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4533-7. PubMed ID: 18674905
    [Abstract] [Full Text] [Related]

  • 11. Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone.
    Costanzo MJ, Yabut SC, Almond HR, Andrade-Gordon P, Corcoran TW, De Garavilla L, Kauffman JA, Abraham WM, Recacha R, Chattopadhyay D, Maryanoff BE.
    J Med Chem; 2003 Aug 28; 46(18):3865-76. PubMed ID: 12930148
    [Abstract] [Full Text] [Related]

  • 12. 1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase.
    Combrink KD, Gülgeze HB, Meanwell NA, Pearce BC, Zulan P, Bisacchi GS, Roberts DG, Stanley P, Seiler SM.
    J Med Chem; 1998 Nov 19; 41(24):4854-60. PubMed ID: 9822554
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors.
    Miyazaki Y, Kato Y, Manabe T, Shimada H, Mizuno M, Egusa T, Ohkouchi M, Shiromizu I, Matsusue T, Yamamoto I.
    Bioorg Med Chem Lett; 2006 Jun 01; 16(11):2986-90. PubMed ID: 16540315
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.
    Hopkins CR, Czekaj M, Kaye SS, Gao Z, Pribish J, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Luo Y, Lim HK, Vaz R, Rebello S, Maignan S, Dupuy A, Mathieu M, Levell J.
    Bioorg Med Chem Lett; 2005 Jun 02; 15(11):2734-7. PubMed ID: 15911249
    [Abstract] [Full Text] [Related]

  • 15. Pyrrole carboxamidine tryptase inhibitors from Leptonychia pubescens.
    Yang LK, Ng SP, Flotow H, Yoganathan K, Daramola BO, Soejarto DD, Buss AD, Butler MS.
    Planta Med; 2005 Nov 02; 71(11):1071-2. PubMed ID: 16320213
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis and biological activity of a targeted library of potential tryptase inhibitors.
    García M, del Rio X, Silvestre S, Rubiralta M, Lozoya E, Segarra V, Fernández D, Miralpeix M, Aparici M, Diez A.
    Org Biomol Chem; 2004 Jun 07; 2(11):1633-42. PubMed ID: 15162216
    [Abstract] [Full Text] [Related]

  • 17. Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
    Levell J, Astles P, Eastwood P, Cairns J, Houille O, Aldous S, Merriman G, Whiteley B, Pribish J, Czekaj M, Liang G, Maignan S, Guilloteau JP, Dupuy A, Davidson J, Harrison T, Morley A, Watson S, Fenton G, McCarthy C, Romano J, Mathew R, Engers D, Gardyan M, Sides K, Kwong J, Tsay J, Rebello S, Shen L, Wang J, Luo Y, Giardino O, Lim HK, Smith K, Pauls H.
    Bioorg Med Chem; 2005 Apr 15; 13(8):2859-72. PubMed ID: 15781396
    [Abstract] [Full Text] [Related]

  • 18. Efficient synthesis of an enantiopure beta-lactam as an advanced precursor of thrombin and tryptase inhibitors.
    Annunziata R, Benaglia M, Cinquini M, Cozzi F, Maggioni F, Puglisi A.
    J Org Chem; 2003 Apr 04; 68(7):2952-5. PubMed ID: 12662075
    [Abstract] [Full Text] [Related]

  • 19. Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.
    Pereira PJ, Bergner A, Macedo-Ribeiro S, Huber R, Matschiner G, Fritz H, Sommerhoff CP, Bode W.
    Nature; 1998 Mar 19; 392(6673):306-11. PubMed ID: 9521329
    [Abstract] [Full Text] [Related]

  • 20. Combinatorial approaches towards the discovery of new tryptase inhibitors.
    del Fresno M, Fernández-Forner D, Miralpeix M, Segarra V, Ryder H, Royo M, Albericio F.
    Bioorg Med Chem Lett; 2005 Mar 15; 15(6):1659-64. PubMed ID: 15745817
    [Abstract] [Full Text] [Related]

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