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Journal Abstract Search

148 related items for PubMed ID: 16725321

  • 21. Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor.
    Scarpi D, McBride JD, Leatherbarrow RJ.
    Bioorg Med Chem; 2004 Dec 01; 12(23):6045-52. PubMed ID: 15519150
    [Abstract] [Full Text] [Related]

  • 22. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
    Greco MN, Hawkins MJ, Powell ET, Almond HR, de Garavilla L, Hall J, Minor LK, Wang Y, Corcoran TW, Di Cera E, Cantwell AM, Savvides SN, Damiano BP, Maryanoff BE.
    J Med Chem; 2007 Apr 19; 50(8):1727-30. PubMed ID: 17361995
    [Abstract] [Full Text] [Related]

  • 23. Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.
    Thomas SA, Li T, Woods KW, Song X, Packard G, Fischer JP, Diebold RB, Liu X, Shi Y, Klinghofer V, Johnson EF, Bouska JJ, Olson A, Guan R, Magnone SR, Marsh K, Luo Y, Rosenberg SH, Giranda VL, Li Q.
    Bioorg Med Chem Lett; 2006 Jul 15; 16(14):3740-4. PubMed ID: 16678413
    [Abstract] [Full Text] [Related]

  • 24. Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.
    Hua Z, Bregman H, Buchanan JL, Chakka N, Guzman-Perez A, Gunaydin H, Huang X, Gu Y, Berry V, Liu J, Teffera Y, Huang L, Egge B, Emkey R, Mullady EL, Schneider S, Andrews PS, Acquaviva L, Dovey J, Mishra A, Newcomb J, Saffran D, Serafino R, Strathdee CA, Turci SM, Stanton M, Wilson C, Dimauro EF.
    J Med Chem; 2013 Dec 27; 56(24):10003-15. PubMed ID: 24294969
    [Abstract] [Full Text] [Related]

  • 25. Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.
    Quan ML, Han Q, Fevig JM, Lam PY, Bai S, Knabb RM, Luettgen JM, Wong PC, Wexler RR.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):1795-8. PubMed ID: 16434195
    [Abstract] [Full Text] [Related]

  • 26. 1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase.
    Wong T, Groutas CS, Mohan S, Lai Z, Alliston KR, Vu N, Schechter NM, Groutas WC.
    Arch Biochem Biophys; 2005 Apr 01; 436(1):1-7. PubMed ID: 15752703
    [Abstract] [Full Text] [Related]

  • 27. Affinity chromatography of tryptases: design, synthesis and characterization of a novel matrix-bound bivalent inhibitor.
    Schaschke N, Gabrijelcic-Geiger D, Dominik A, Sommerhoff CP.
    Chembiochem; 2005 Jan 01; 6(1):95-103. PubMed ID: 15593113
    [Abstract] [Full Text] [Related]

  • 28. Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase.
    Hallgren J, Lindahl S, Pejler G.
    J Mol Biol; 2005 Jan 07; 345(1):129-39. PubMed ID: 15567416
    [Abstract] [Full Text] [Related]

  • 29. Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G.
    Maryanoff BE.
    J Med Chem; 2004 Feb 12; 47(4):769-87. PubMed ID: 14761180
    [No Abstract] [Full Text] [Related]

  • 30. Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCbeta-selective inhibitors.
    Tanaka M, Sagawa S, Hoshi J, Shimoma F, Yasue K, Ubukata M, Ikemoto T, Hase Y, Takahashi M, Sasase T, Ueda N, Matsushita M, Inaba T.
    Bioorg Med Chem; 2006 Sep 01; 14(17):5781-94. PubMed ID: 16762554
    [Abstract] [Full Text] [Related]

  • 31. Structure-guided design of peptide-based tryptase inhibitors.
    McGrath ME, Sprengeler PA, Hirschbein B, Somoza JR, Lehoux I, Janc JW, Gjerstad E, Graupe M, Estiarte A, Venkataramani C, Liu Y, Yee R, Ho JD, Green MJ, Lee CS, Liu L, Tai V, Spencer J, Sperandio D, Katz BA.
    Biochemistry; 2006 May 16; 45(19):5964-73. PubMed ID: 16681368
    [Abstract] [Full Text] [Related]

  • 32. Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.
    Cheng Y, Albrecht BK, Brown J, Buchanan JL, Buckner WH, DiMauro EF, Emkey R, Fremeau RT, Harmange JC, Hoffman BJ, Huang L, Huang M, Lee JH, Lin FF, Martin MW, Nguyen HQ, Patel VF, Tomlinson SA, White RD, Xia X, Hitchcock SA.
    J Med Chem; 2008 Aug 28; 51(16):5019-34. PubMed ID: 18680277
    [Abstract] [Full Text] [Related]

  • 33. Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).
    Sun D, Wang Z, Cardozo M, Choi R, Degraffenreid M, Di Y, He X, Jaen JC, Labelle M, Liu J, Ma J, Miao S, Sudom A, Tang L, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP.
    Bioorg Med Chem Lett; 2009 Mar 01; 19(5):1522-7. PubMed ID: 19181519
    [Abstract] [Full Text] [Related]

  • 34. 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors.
    Jia ZJ, Wu Y, Huang W, Zhang P, Song Y, Woolfrey J, Sinha U, Arfsten AE, Edwards ST, Hutchaleelaha A, Hollennbach SJ, Lambing JL, Scarborough RM, Zhu BY.
    Bioorg Med Chem Lett; 2004 Mar 08; 14(5):1229-34. PubMed ID: 14980671
    [Abstract] [Full Text] [Related]

  • 35. Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.
    Dener JM, Wang VR, Rice KD, Gangloff AR, Kuo EY, Newcomb WS, Putnam D, Wong M.
    Bioorg Med Chem Lett; 2001 Sep 03; 11(17):2325-30. PubMed ID: 11527724
    [Abstract] [Full Text] [Related]

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  • 37. Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors.
    Mizutani T, Ishikawa S, Nagase T, Takahashi H, Fujimura T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N.
    J Med Chem; 2009 Nov 26; 52(22):7289-300. PubMed ID: 19883081
    [Abstract] [Full Text] [Related]

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  • 40. Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
    Tao ZF, Hasvold LA, Leverson JD, Han EK, Guan R, Johnson EF, Stoll VS, Stewart KD, Stamper G, Soni N, Bouska JJ, Luo Y, Sowin TJ, Lin NH, Giranda VS, Rosenberg SH, Penning TD.
    J Med Chem; 2009 Nov 12; 52(21):6621-36. PubMed ID: 19842661
    [Abstract] [Full Text] [Related]

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