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85 related items for PubMed ID: 16728593

  • 1. Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.
    Ilyin VI, Pomonis JD, Whiteside GT, Harrison JE, Pearson MS, Mark L, Turchin PI, Gottshall S, Carter RB, Nguyen P, Hogenkamp DJ, Olanrewaju S, Benjamin E, Woodward RM.
    J Pharmacol Exp Ther; 2006 Sep; 318(3):1083-93. PubMed ID: 16728593
    [Abstract] [Full Text] [Related]

  • 2. V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels.
    Ilyin VI, Hodges DD, Whittemore ER, Carter RB, Cai SX, Woodward RM.
    Br J Pharmacol; 2005 Mar; 144(6):801-12. PubMed ID: 15778702
    [Abstract] [Full Text] [Related]

  • 3. A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
    Zhang XF, Shieh CC, Chapman ML, Matulenko MA, Hakeem AH, Atkinson RN, Kort ME, Marron BE, Joshi S, Honore P, Faltynek CR, Krafte DS, Jarvis MF.
    Neuropharmacology; 2010 Sep; 59(3):201-7. PubMed ID: 20566409
    [Abstract] [Full Text] [Related]

  • 4. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
    Jarvis MF, Honore P, Shieh CC, Chapman M, Joshi S, Zhang XF, Kort M, Carroll W, Marron B, Atkinson R, Thomas J, Liu D, Krambis M, Liu Y, McGaraughty S, Chu K, Roeloffs R, Zhong C, Mikusa JP, Hernandez G, Gauvin D, Wade C, Zhu C, Pai M, Scanio M, Shi L, Drizin I, Gregg R, Matulenko M, Hakeem A, Gross M, Johnson M, Marsh K, Wagoner PK, Sullivan JP, Faltynek CR, Krafte DS.
    Proc Natl Acad Sci U S A; 2007 May 15; 104(20):8520-5. PubMed ID: 17483457
    [Abstract] [Full Text] [Related]

  • 5. Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine.
    Sheets PL, Heers C, Stoehr T, Cummins TR.
    J Pharmacol Exp Ther; 2008 Jul 15; 326(1):89-99. PubMed ID: 18378801
    [Abstract] [Full Text] [Related]

  • 6. Comparative evaluation of in vitro and in vivo high glucose-induced alterations in voltage-gated tetrodotoxin-resistant sodium channel: Effects attenuated by sodium channel blockers.
    Kharatmal SB, Singh JN, Sharma SS.
    Neuroscience; 2015 Oct 01; 305():183-96. PubMed ID: 26255676
    [Abstract] [Full Text] [Related]

  • 7. Characterization of a model of chronic orofacial hyperalgesia in the rat: contribution of NA(V) 1.8.
    Morgan JR, Gebhart GF.
    J Pain; 2008 Jun 01; 9(6):522-31. PubMed ID: 18337185
    [Abstract] [Full Text] [Related]

  • 8. Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker.
    Abbadie C, McManus OB, Sun SY, Bugianesi RM, Dai G, Haedo RJ, Herrington JB, Kaczorowski GJ, Smith MM, Swensen AM, Warren VA, Williams B, Arneric SP, Eduljee C, Snutch TP, Tringham EW, Jochnowitz N, Liang A, Euan MacIntyre D, McGowan E, Mistry S, White VV, Hoyt SB, London C, Lyons KA, Bunting PB, Volksdorf S, Duffy JL.
    J Pharmacol Exp Ther; 2010 Aug 01; 334(2):545-55. PubMed ID: 20439438
    [Abstract] [Full Text] [Related]

  • 9. Thiamine suppresses thermal hyperalgesia, inhibits hyperexcitability, and lessens alterations of sodium currents in injured, dorsal root ganglion neurons in rats.
    Song XS, Huang ZJ, Song XJ.
    Anesthesiology; 2009 Feb 01; 110(2):387-400. PubMed ID: 19194165
    [Abstract] [Full Text] [Related]

  • 10. Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels.
    Leffler A, Reiprich A, Mohapatra DP, Nau C.
    J Pharmacol Exp Ther; 2007 Jan 01; 320(1):354-64. PubMed ID: 17005919
    [Abstract] [Full Text] [Related]

  • 11. muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits.
    Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ.
    Proc Natl Acad Sci U S A; 2006 Nov 07; 103(45):17030-5. PubMed ID: 17077153
    [Abstract] [Full Text] [Related]

  • 12. Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat.
    Gould HJ, England JD, Soignier RD, Nolan P, Minor LD, Liu ZP, Levinson SR, Paul D.
    J Pain; 2004 Jun 07; 5(5):270-80. PubMed ID: 15219259
    [Abstract] [Full Text] [Related]

  • 13. In vitro hyperglycemia enhances sodium currents in dorsal root ganglion neurons: an effect attenuated by carbamazepine.
    Singh JN, Jain G, Sharma SS.
    Neuroscience; 2013 Mar 01; 232():64-73. PubMed ID: 23262239
    [Abstract] [Full Text] [Related]

  • 14. A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
    Erichsen HK, Hao JX, Xu XJ, Blackburn-Munro G.
    Eur J Pharmacol; 2003 Jan 05; 458(3):275-82. PubMed ID: 12504783
    [Abstract] [Full Text] [Related]

  • 15. Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons.
    Shen KF, Zhu HQ, Wei XH, Wang J, Li YY, Pang RP, Liu XG.
    Exp Neurol; 2013 Sep 05; 247():466-75. PubMed ID: 23357618
    [Abstract] [Full Text] [Related]

  • 16. Sodium channel blockade may contribute to the analgesic efficacy of antidepressants.
    Dick IE, Brochu RM, Purohit Y, Kaczorowski GJ, Martin WJ, Priest BT.
    J Pain; 2007 Apr 05; 8(4):315-24. PubMed ID: 17175203
    [Abstract] [Full Text] [Related]

  • 17. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.
    Macsari I, Besidski Y, Csjernyik G, Nilsson LI, Sandberg L, Yngve U, Ahlin K, Bueters T, Eriksson AB, Lund PE, Venyike E, Oerther S, Hygge Blakeman K, Luo L, Arvidsson PI.
    J Med Chem; 2012 Aug 09; 55(15):6866-80. PubMed ID: 22770500
    [Abstract] [Full Text] [Related]

  • 18. Voltage-gated sodium channel function and expression in injured and uninjured rat dorsal root ganglia neurons.
    Yin R, Liu D, Chhoa M, Li CM, Luo Y, Zhang M, Lehto SG, Immke DC, Moyer BD.
    Int J Neurosci; 2016 Aug 09; 126(2):182-92. PubMed ID: 25562420
    [Abstract] [Full Text] [Related]

  • 19. The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers.
    Kahlig KM, Scott L, Hatch RJ, Griffin A, Martinez Botella G, Hughes ZA, Wittmann M.
    Epilepsia; 2022 Mar 09; 63(3):697-708. PubMed ID: 35037706
    [Abstract] [Full Text] [Related]

  • 20. Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones.
    Kuo CC, Lu L.
    Br J Pharmacol; 1997 Jul 09; 121(6):1231-8. PubMed ID: 9249262
    [Abstract] [Full Text] [Related]

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